X0306 4 2016-03-22 0 0000831547 SPECTRUM PHARMACEUTICALS INC SPPI 0001193918 SHROTRIYA RAJESH C MD 11500 S. EASTERN AVE. SUITE 240 HENDERSON NV 89052 1 1 1 0 Chairman & CEO Common Stock, $0.001 par value 2016-03-22 4 A 0 100000 0.00 A 1793249 D Common Stock, $0.001 par value 2016-03-22 4 F 0 6838 6.08 D 1786411 D Common Stock, $0.001 par value 498894 I By CS Family Trust Common Stock, $0.001 par value 27078 I By 401(k) Plan Common Stock, $0.001 par value 87018 I By Shrotriya Gift Common Stock, $0.001 par value 9523 I By Spouse Common Stock, $0.001 par value 73669 I By Shrotriya Family Foundation Common Stock, $0.001 par value 10613 I By Shrotriya Annuity Trust 25% of the restricted shares vested on March 22, 2016. The remaining restricted shares shall vest in 25% equal annual amounts on each anniversary date of the grant over three years. Represents restricted shares withheld by Spectrum to satisfy Reporting Person's tax withholding obligations. The shares have not been sold by the Reporting Person or by Spectrum. The shares have been cancelled by the transfer agent. /s/ Kurt A. Gustafson, attorney-in-fact for Rajesh C. Shrotriya 2016-03-24