Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $) In Thousands	9 Months Ended
Sep. 30, 2011	Sep. 30, 2010
Cash Flows From Operating Activities:
Net income (loss)	$ 40,236	$ (53,284)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Amortization of deferred revenue	(9,225)	(10,117)
Depreciation and amortization	3,991	3,320
Stock-based compensation	15,216	6,267
Change in fair value of common stock warrant liability	3,488	(6,030)
Fair value of common stock issued in connection with asset acquisition		1,661
Provision for bad debt	189
Loss on disposal of assets	31
Changes in operating assets and liabilities:
Accounts receivable, net	(26,904)	(807)
Inventories, net	(6,051)	(565)
Prepaid expenses and other assets	316	(277)
Accounts payable and other accrued obligations	6,350	9,516
Accrued compensation and related expenses	325	(804)
Accrued drug development costs	4,460	406
Landlord contributions to tenant improvements		995
Deferred revenue and other credits	(97)	16,896
Net cash provided by (used in) operating activities	32,325	(32,823)
Cash Flows From Investing Activities:
Maturities of marketable securities	22,156
Purchases of marketable securities	(21,968)	(4,097)
Purchases of property and equipment	(380)	(1,396)
Purchases of available for sale securities	(164)
Net cash used in investing activities	(356)	(5,493)
Cash Flows From Financing Activities:
Proceeds from issuance of common stock from stock option exercises	2,388	1,082
Proceeds from issuance of common stock from warrant exercises	24,808
Proceeds from contributions to ESPP	434	306
Payments to acquire treasury stock	(2,840)
Repayment of capital leases	(23)	(21)
Net cash provided by financing activities	24,767	1,367
Net increase (decrease) in cash and cash equivalents	56,736	(36,949)
Cash and cash equivalents--beginning of period	53,557	82,336
Cash and cash equivalents--end of period	110,293	45,387
Supplemental Disclosure of Cash Flow Information:
Conversion of preferred stock to common stock	37
Common stock issued for Targent milestones	11,778
Targent milestones included in intangible assets and accrued liabilities	$ 5,000

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The cash outflow to acquire debt securities classified as available-for-sale securities, because they are not classified as either held-to-maturity securities or trading securities.

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The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets.

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The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period.

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The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately.

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The cash inflow associated with the amount received from holders exercising their stock warrants.

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Amount of the current period expense charged against operations, the offset which is generally to the allowance for doubtful accounts for the purpose of reducing receivables, including notes receivable, to an amount that approximates their net realizable value (the amount expected to be collected).

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The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer).

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