Stock-Based Compensation - Summary of Stock Option Activity (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Number of Shares
Outstanding, beginning (in shares)	9,505,461	7,656,623
Granted (in shares)	6,885,316	2,397,684
Exercised (in shares)	0	(1,250)
Forfeited (in shares)	(1,230,311)	(34,565)
Expired (in shares)	(1,683,843)	(513,031)
Outstanding, ending (in shares)	13,476,623	9,505,461
Expected to Vest (in shares)	6,090,775
Vested and Exercisable (in shares)	6,594,608
Weighted- Average Exercise Price/Share
Outstanding, beginning (in dollars per share)	$ 6.42	$ 7.80
Granted (in dollars per share)	0.68	2.66
Exercised (in dollars per share)	0	3.04
Forfeited (in dollars per share)	1.22	10.05
Expired (in dollars per share)	7.65	9.29
Outstanding, ending (in dollars per share)	3.81	$ 6.42
Expected to Vest (in dollars per share)	1.10
Vested and Exercisable (in dollars per share)	$ 6.64
Weighted-Average Remaining Contractual Term (in years), Outstanding	6 years 9 months 18 days
Weighted-Average Remaining Contractual Term (in years), Expected to Vest	9 years 10 days
Weighted-Average Remaining Contractual Term (in years), Vested and Exercisable	4 years 5 months 12 days
Aggregate Intrinsic Value, Exercised	$ 0	$ 1,500
Aggregate Intrinsic Value, Outstanding	0
Aggregate Intrinsic Value, Expected to Vest	0
Aggregate Intrinsic Value, Vested and Exercisable	$ 0