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Income Taxes (Tables)
 12 Months Ended
Dec. 31, 2022
Income Tax Disclosure [Abstract]  
Schedule of Components of Loss before Benefit for Income Taxes The components of loss before benefit for income taxes from continuing operations are as follows:
Year Ended December 31,
20222021
United States$(78,126)$(158,552)
Foreign68 120 
Total$(78,058)$(158,432)
Schedule of Provision for Income Taxes The provision for income taxes from continuing operations consist of the following:
Year Ended December 31,
20222021
Current:
Federal$— $— 
State— — 
Foreign46 4 
$46 $4 
Deferred:
Federal— — 
State— — 
Foreign— — 
— — 
Total income tax expense$46 $4 
Schedule of Income Tax Expense Reconciliation The income tax expense differs from that computed using the applicable federal statutory rate, as applied to our income before taxes in each year as follows:
Year Ended December 31,
20222021
Tax provision computed at the federal statutory rate$(16,392)$(33,210)
State tax, net of federal benefit(2,913)(11,050)
Research and development expense tax credits(328)(1,838)
Officers compensation(738)1,988 
Stock based compensation2,688 1,234 
Permanent items and other157 (173)
Change in tax rate3,288 (6,671)
Change in prior year deferred taxes568 (353)
Valuation allowance13,716 50,077 
Income tax expense$46 $4 
Schedule of Components of Deferred Tax Assets and Liabilities Significant components of our deferred tax assets and liabilities as of December 31, 2022 and 2021 are presented below. A valuation allowance has been recognized to offset the net deferred tax assets as realization of such deferred tax assets did not meet our “more-likely-than-not” assessment threshold, as required under GAAP.
December 31,
20222021
Deferred tax assets:
Net operating loss carry forwards$198,162 $187,129 
Research and development expense tax credits27,669 27,341 
Stock based compensation4,136 5,470 
Lease obligation456 783 
ROLVEDON supplies9,337 — 
Returns and allowances636 1,198 
Amortization differences857 1,749 
Capitalized research and development expenses12,218 — 
Other, net3,114 20,610 
Total deferred tax assets before valuation allowance256,585 244,280 
Valuation allowance(256,063)(242,590)
Total deferred tax assets522 1,690 
Deferred tax liabilities, net:
Unrealized gains(97)(973)
Right-of-use asset(425)(717)
Net deferred tax liabilities$— $— 
Schedule of Unrecognized Tax Benefits The following tabular reconciliation summarizes the activity related to our unrecognized tax benefits:
Year Ended December 31,
20222021
Balance at beginning of year$3,524 $3,336 
Adjustments related to prior year tax positions— (318)
Increases related to current year tax positions102 506 
Balance at end of year$3,626 $3,524