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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash Flows From Operating Activities:    
Loss from continuing operations $ (66,376) $ (118,686)
Loss from discontinued operations, net of income taxes (39) (227)
Net loss (66,415) (118,913)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 200 212
Amortization of debt discount 17 0
Stock-based compensation 7,635 12,686
Non-cash lease expense 539 1,151
Other non-cash items 88 281
Loss on disposal of manufacturing equipment 0 3,057
Loss on disposal of assets 2 0
Realized loss (gain) on sale of equity holdings 1,094 (4,580)
Unrealized loss on equity holdings 3,352 12,816
Changes in operating assets and liabilities:    
Accounts receivable, net 0 66
Other receivables 431 (1,391)
Inventories (9,373) 0
Prepaid expenses and other current assets (617) 1,620
Other assets 976 (89)
Accounts payable and other accrued liabilities 389 4,376
Accrued payroll and benefits (4,360) (1,085)
Other long-term liabilities (5,609) 654
Net cash used in operating activities (71,651) (89,139)
Cash Flows From Investing Activities:    
Proceeds from maturities of investments 2,799 109,771
Proceeds from sale of equity holdings 2,028 4,406
Purchases of investments (41,023) (16,568)
Purchases of property and equipment, net (45) (140)
Net cash (used in) provided by investing activities (36,241) 97,469
Cash Flows From Financing Activities:    
Issuance of common shares to Hanmi Pharmaceutical Co., Ltd. 20,000 0
Proceeds from the issuance of debt, net of debt issuance costs 28,852 0
Proceeds from sale of common stock under an at-the-market sales agreement, net 26,560 52,622
Proceeds from sale of stock under our employee stock purchase plan 257 474
Proceeds from employees for exercises of stock options 0 4
Net cash provided by financing activities 75,669 53,100
Effect of exchange rates on cash and cash equivalents (61) (4)
Net (decrease) increase in cash and cash equivalents (32,284) 61,426
Cash and cash equivalents—beginning of period 88,539 46,009
Cash and cash equivalents—end of period 56,255 107,435
Supplemental disclosure of cash flow information:    
Cash paid for facility and equipment under operating leases 1,492 1,626
Cash paid for income taxes 0 12
Supplemental disclosures of non-cash financing activity:    
Issuance of warrants in connection with debt financing 230 0
Debt issuance costs in accrued liabilities $ 152 $ 0