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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
We report our stock-based compensation expense (inclusive of our incentive stock plan and employee stock purchase plan) in the accompanying Condensed Consolidated Statements of Operations within “total operating costs and expenses” for the three and nine months ended September 30, 2022 and 2021, as follows:
 Three Months Ended
September 30,		Nine Months Ended
September 30,
 2022202120222021
Selling, general and administrative$1,477 $2,927 $4,589 $8,730 
Research and development1,070 1,187 3,046 3,956 
Total stock-based compensation$2,547 $4,114 $7,635 $12,686 
Schedule of Restricted Stock Award and Restricted Stock Units Activity
The following table summarizes activity related to restricted stock awards (“RSAs”) for the nine months ended September 30, 2022:
Number of
Restricted Stock
Awards		Weighted Average
Fair Value per
Share at Grant
Date
Unvested at December 31, 20214,436,007 $3.33 
Granted2,160,240 1.20 
Vested(1,804,526)3.77 
Forfeited(875,513)2.61 
Unvested at September 30, 20223,916,208 $2.11 
The following table summarizes activity related to restricted stock units (“RSUs”) for the nine months ended September 30, 2022:
Number of
Restricted Stock
Units		Weighted Average
Fair Value per
Share at Grant
Date
Outstanding at December 31, 2021184,512 $23.53 
Granted1,677,552 0.71 
Vested— — 
Forfeited(4,512)— 
Outstanding at September 30, 20221,857,552 $0.71 
Schedule of Stock Option Activity The following table summarizes stock option activity for the nine months ended September 30, 2022:
Number of
Shares		Weighted-
Average
Exercise
Price/Share		Weighted-
Average
Remaining
Contractual
Term (Years)		Aggregate
Intrinsic
Value
Outstanding at December 31, 20219,505,461 $6.42 5.86
Granted6,885,316 0.68 
Exercised— — $— 
Forfeited(181,914)3.34 
Expired(1,239,985)7.28 
Outstanding at September 30, 202214,968,878 $3.74 7.59$— 
Vested and Expected to Vest at September 30, 20227,760,304 $1.08 9.26$— 
Exercisable at September 30, 20226,045,584 $7.68 5.12$— 
Schedule of Fair Value of Stock Options Granted Using Black-Scholes Option Pricing Model
The Company used the Black-Scholes option pricing model for determining the estimated fair value of stock-based compensation related to stock options. The table below summarizes the assumptions used:

Nine Months Ended September 30,
20222021
Expected life (in years)5.575.50
Risk-free interest rate
1.70% - 3.30%
0.56% - 1.01%
Expected volatility
83.6% - 90.5%
80.0% - 81.3%
Expected dividend yield—%—%
Weighted-average grant-date fair value per stock option$0.48$2.42