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Income Taxes (Tables)
 12 Months Ended
Dec. 31, 2021
Income Tax Disclosure [Abstract]  
Schedule of Components of Loss before Benefit for Income Taxes The components of loss before benefit for income taxes from continuing operations are as follows:
Year Ended December 31,
20212020
United States$(158,552)$(173,398)
Foreign120 2,066 
Total$(158,432)$(171,332)
Schedule of Benefit from Income Taxes The benefit for income taxes from continuing operations consist of the following:
Year Ended December 31,
20212020
Current:
Federal$— $— 
State— (76)
Foreign4 16 
$4 $(60)
Deferred:
Federal— — 
State— — 
— — 
Total income tax expense (benefit) $4 $(60)
Schedule of Income Tax Benefit Differs from Computed Using Federal Statutory Rate Applied to Income before Taxes The income tax benefit differs from that computed using the applicable federal statutory rate, as applied to our income before taxes in each year as follows:
Year Ended December 31,
20212020
Tax provision computed at the federal statutory rate$(33,210)$(35,980)
State tax, net of federal benefit(11,050)(5,142)
Research and development expense tax credits(1,838)(2,686)
Change in uncertain tax benefit reserve— (27)
Change in tax credit carryforwards— 109 
Officers compensation1,988 2,497 
Stock based compensation1,234 1,619 
Permanent items and other(173)(37)
Tax differential on foreign earnings— (1)
Change in tax rate(6,671)(1,091)
Change in prior year deferred taxes(353)(998)
Valuation allowance50,077 41,677 
Income tax expense (benefit)$4 $(60)
Schedule of Components of Company's Deferred Tax Assets Significant components of our deferred tax assets and liabilities as of December 31, 2021 and 2020 are presented below. A valuation allowance has been recognized to offset the net deferred tax assets as realization of such deferred tax assets did not meet our “more-likely-than-not” assessment threshold, as required under GAAP.
December 31,
20212020
Deferred tax assets:
Net operating loss carry forwards$187,129 $143,045 
Research and development expense tax credits27,341 25,424 
Stock based compensation5,470 4,037 
Lease obligation783 599 
Development costs286 487 
Returns and allowances1,198 1,061 
Amortization differences1,749 1,479 
Depreciation57 4,746 
Other, net20,267 17,420 
Total deferred tax assets before valuation allowance244,280 198,298 
Valuation allowance(242,590)(192,513)
Total deferred tax assets1,690 5,785 
Deferred tax liabilities, net:
Unrealized gains(973)(5,230)
Right-of-use asset(717)(555)
Net deferred tax liabilities$— $— 
Schedule of Unrecognized Tax Benefits The following tabular reconciliation summarizes the activity related to our unrecognized tax benefits:
Year Ended December 31,
20212020
Balance at beginning of year$3,336 $3,473 
Adjustments related to prior year tax positions(318)(689)
Increases related to current year tax positions506 579 
Decreases due to expiration of tax statutes— (27)
Balance at end of year$3,524 $3,336