Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock [Member]	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Total Stockholders Equity [Member]	ROLONTIS [Member] Common Stock [Member]	ROLONTIS [Member] Additional Paid-In Capital [Member]	ROLONTIS [Member] Total Stockholders Equity [Member]	QAPZOLA [Member] Common Stock [Member]	QAPZOLA [Member] Additional Paid-In Capital [Member]	QAPZOLA [Member] Total Stockholders Equity [Member]
Beginning Balance at Dec. 31, 2015		$ 123	$ 68	$ 559,068	$ (5,319)	$ (341,083)	$ 212,857
Beginning Balance, (shares) at Dec. 31, 2015		20	68,228,935
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	$ (69,770)					(69,770)	(69,770)
Other comprehensive income (loss), net	$ 3,740				3,740		3,740
Issuance of common stock to 401(k) plan				953			953
Issuance of common stock to 401(k) plan, (shares)			172,650
Issuance of common stock for ESPP				668			668
Issuance of common stock for ESPP, (shares)			150,303
Issuance of common stock upon exercise of stock options				202			202
Issuance of common stock upon exercise of stock options, (shares)	39,010		39,010
RSA and stock option issuances and forfeitures for terminations, net	$ 1			12,717			12,718
RSA and stock option issuances and forfeitures for terminations, net, (shares)			868,032
Repurchase/retirement of RSAs to satisfy employee tax withholding				(1,397)			(1,397)
Repurchase/retirement of RSAs to satisfy employee tax withholding (shares)			(266,860)
Common stock issued under an at-the-market sales agreement (Note 7)			$ 11	73,858			73,869
Common stock issued under an at-the-market sales agreement (Note 7) (shares)	10,890,915		10,890,915
Issuance of common stock for milestone achievement									$ 2,308	$ 2,308		$ 111	$ 111
Issuance of common stock for milestone achievement, (shares)								318,750			25,000
Conversion hedge unwind in connection with open market purchases of 2018 Convertible Notes (Note 15)				(227)			(227)
Conversion of preferred shares into common stock (Note 7)		$ (123)		123			0
Conversion of preferred shares into common stock (Note 7) (shares)		(20)	40,000
Dividend paid on preferred shares (Note 7)	$ (6)					(6)
Ending Balance at Dec. 31, 2016		$ 0	$ 80	648,384	(1,579)	(410,859)	236,026
Ending Balance, (shares) at Dec. 31, 2016		0	80,466,735
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(91,248)					(91,248)	(91,248)
Other comprehensive income (loss), net	$ 17,578				17,578		17,578
Issuance of common stock to 401(k) plan				912			912
Issuance of common stock to 401(k) plan, (shares)			102,874
Issuance of common stock for ESPP				1,010			1,010
Issuance of common stock for ESPP, (shares)			203,229
Issuance of common stock upon exercise of stock options			$ 1	5,477			5,478
Issuance of common stock upon exercise of stock options, (shares)	937,482		864,897
RSA and stock option issuances and forfeitures for terminations, net				13,197			13,197
RSA and stock option issuances and forfeitures for terminations, net, (shares)			548,394
Repurchase/retirement of RSAs to satisfy employee tax withholding				(4,331)			(4,331)
Repurchase/retirement of RSAs to satisfy employee tax withholding (shares)			(373,822)
Issuance of common stock upon vesting of RSUs				1,030			1,030
Common stock issued under an at-the-market sales agreement (Note 7)			$ 14	128,258			128,272
Common stock issued under an at-the-market sales agreement (Note 7) (shares)			13,558,132
Conversion hedge unwind in connection with open market purchases of 2018 Convertible Notes (Note 15)			$ 5	43,410			43,415
Conversion hedge unwind in connection with open market purchases of 2018 Convertible Notes (Note 15) (shares)			5,372,296
Ending Balance at Dec. 31, 2017	$ 351,339	$ 0	$ 100	837,347	15,999	(502,107)	351,339
Ending Balance, (shares) at Dec. 31, 2017	100,742,735	0	100,742,735
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Cumulative-effect adjustment of adopting ASUs | Accounting Standards Update 2016-01 [Member]					(17,200)	17,200
Net loss	$ (120,011)					(120,011)	(120,011)
Other comprehensive income (loss), net	$ (2,490)				(2,490)		(2,490)
Issuance of common stock to 401(k) plan				1,175			1,175
Issuance of common stock to 401(k) plan, (shares)			70,379
Issuance of common stock for ESPP				1,122			1,122
Issuance of common stock for ESPP, (shares)			97,804
Issuance of common stock upon exercise of stock options			$ 8	52,977			52,985
Issuance of common stock upon exercise of stock options, (shares)	7,858,141		7,858,141
RSA and stock option issuances and forfeitures for terminations, net			$ 1	14,113			14,114
RSA and stock option issuances and forfeitures for terminations, net, (shares)			874,532
Repurchase/retirement of RSAs to satisfy employee tax withholding			$ (3)	(62,541)			(62,544)
Repurchase/retirement of RSAs to satisfy employee tax withholding (shares)			(3,463,873)
Issuance of common stock upon vesting of RSUs	$ 2,196			2,196
Issuance of common stock upon vesting of RSUs (shares)			200,652
Issuance of common stock upon exercise of warrants	0
Issuance of common stock upon exercise of warrants (shares)			292,575
Conversion hedge unwind in connection with open market purchases of 2018 Convertible Notes (Note 15)			$ 4	40,351			40,355
Conversion hedge unwind in connection with open market purchases of 2018 Convertible Notes (Note 15) (shares)			3,852,196
Ending Balance at Dec. 31, 2018	$ 283,262	$ 0	$ 110	$ 886,740	$ (3,702)	$ (599,886)	$ 283,262
Ending Balance, (shares) at Dec. 31, 2018	110,525,141	0	110,525,141