Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues:
Total revenues	$ 109,333	$ 128,367	$ 146,444
Operating costs and expenses:
Selling, general and administrative	90,700	84,267	88,418
Research and development	94,956	65,895	59,123
Amortization of intangible assets	28,098	27,647	25,946
Total operating costs and expenses	240,510	225,027	209,330
Loss from operations	(131,177)	(96,660)	(62,886)
Other income (expense):
Interest expense, net	(340)	(6,798)	(9,435)
Change in fair value of contingent consideration related to acquisitions	1,927	(4,957)	(649)
Other income, net	9,580	389	887
Total other income (expenses)	11,167	(11,366)	(9,197)
Loss before income taxes	(120,010)	(108,026)	(72,083)
(Provision) benefit for income taxes	(1)	16,778	2,313
Net loss	$ (120,011)	$ (91,248)	$ (69,770)
Net loss per share:
Basic ($ per share)	$ (1.16)	$ (1.07)	$ (0.96)
Diluted ($ per share)	$ (1.16)	$ (1.07)	$ (0.96)
Weighted average shares outstanding:
Basic (shares)	103,305,911	85,115,592	72,824,070
Diluted (shares)	103,305,911	85,115,592	72,824,070
Product [Member]
Revenues:
Total revenues	$ 104,466	$ 116,178	$ 128,596
Operating costs and expenses:
Cost of sales (excludes amortization of intangible assets)	26,756	42,859	27,953
License and Service [Member]
Revenues:
Total revenues	4,867	12,189	17,848
Service [Member]
Operating costs and expenses:
Cost of service revenue	$ 0	$ 4,359	$ 7,890