Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017
Cash Flows From Operating Activities:
Net loss	$ (70,792)	$ (62,691)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	21,000	20,965
Stock-based compensation	13,197	10,201
Accretion of debt discount on 2018 Convertible Notes, recorded to interest expense (Note 13)	1,558	4,236
Amortization of deferred financing costs on 2018 Convertible Notes, recorded to interest expense (Note 13)	178	491
Unrealized loss (gains) from transactions denominated in foreign currency	17	(18)
Change in cash surrender value of corporate-owned life insurance policy	(5)	(266)
Deferred tax liabilities	9	154
Income tax recognition on unrealized gain for available-for-sale securities	0	(2,068)
Unrealized gains on marketable securities (Note 3(a))	(17,716)	0
Change in fair value of contingent consideration related to the Talon and EVOMELA acquisitions (Note 9)	(717)	3,236
Changes in operating assets and liabilities:
Accounts receivable, net	3,252	2,143
Other receivables	(3,002)	(88)
Inventories	2,862	554
Prepaid expenses	(2,362)	972
Other assets	4,890	183
Accounts payable and other accrued obligations	(457)	(2,954)
Accrued payroll and benefits	(1,517)	(1,343)
FOLOTYN development liability	(270)	(704)
Deferred revenue	0	(483)
Other long-term liabilities	(218)	1,523
Net cash used in operating activities	(50,093)	(25,957)
Cash Flows From Investing Activities:
Proceeds from redemption of corporate-owned life insurance policy	4,130	0
Payment for corporate-owned life insurance premiums	0	(601)
Redemption of mutual funds	0	(1)
Purchases of property and equipment	(46)	(412)
Net cash provided by (used in) investing activities	4,084	(1,014)
Cash Flows From Financing Activities:
Proceeds from employees for exercises of stock options	7,843	3,051
Proceeds from sale of stock under our employee stock purchase plan	734	406
Proceeds from employees, for our remittance to tax authorities, upon vesting of restricted stock and exercises of stock options	4,645	0
Payments to tax authorities upon employees' surrender of restricted stock at vesting and exercises of stock options	(27,686)	(1,476)
Proceeds from sale of common stock under an at-the-market sales agreement (Note 17)	0	113,966
Net cash (used in) provided by financing activities	(14,464)	115,947
Effect of exchange rates on cash and equivalents	(309)	270
Net (decrease) increase in cash and cash equivalents	(60,782)	89,246
Cash and cash equivalents—beginning of period	227,323	158,222
Cash and cash equivalents—end of period	166,541	247,468
Supplemental disclosure of cash flow information:
Cash paid for income taxes	38	10
Cash paid for interest	$ 558	$ 1,513