Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017
Cash Flows From Operating Activities:
Net loss	$ (2,074)	$ (44,398)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	13,993	13,961
Stock-based compensation	9,211	7,207
Accretion of debt discount on 2018 Convertible Notes, recorded to interest expense (Note 13)	1,079	2,794
Amortization of deferred financing costs on 2018 Convertible Notes, recorded to interest expense (Note 13)	124	321
Unrealized gains from transactions denominated in foreign currency	10	(15)
Change in cash surrender value of corporate-owned life insurance policy	(5)	(153)
Deferred tax liabilities	9	127
Income tax recognition on unrealized gain for available-for-sale securities	0	0
Unrealized gains on marketable securities (Note 3(a))	(58,634)	0
Change in fair value of contingent consideration related to the Talon and EVOMELA acquisitions (Note 9)	483	294
Changes in operating assets and liabilities:
Accounts receivable, net	5,087	(2,105)
Other receivables	(781)	1,299
Inventories	816	428
Prepaid expenses	1,167	(439)
Other assets	3,451	863
Accounts payable and other accrued obligations	(8,210)	3,519
Accrued payroll and benefits	(4,314)	(2,737)
FOLOTYN development liability	(195)	(567)
Deferred revenue	0	(700)
Other long-term liabilities	(464)	847
Net cash used in operating activities	(39,247)	(19,454)
Cash Flows From Investing Activities:
Proceeds from redemption of corporate-owned life insurance policy	4,130	0
Payment for corporate-owned life insurance premiums	0	(601)
Redemption of mutual funds	0	(1)
Purchases of property and equipment	(46)	(167)
Net cash provided by (used in) investing activities	4,084	(769)
Cash Flows From Financing Activities:
Proceeds from employees for exercises of stock options	4,804	1,010
Proceeds from sale of stock under employee stock purchase plan	734	406
Proceeds from employees, for our remittance to tax authorities, related to employee vesting of restricted stock and stock option exercises	4,645	0
Payments to tax authorities related to employee surrender of vested restricted stock and stock option exercises	(27,686)	(1,284)
Net cash (used in) provided by financing activities	(17,503)	132
Effect of exchange rates on cash and equivalents	(286)	182
Net decrease in cash and cash equivalents	(52,952)	(19,909)
Cash and cash equivalents—beginning of period	227,323	158,222
Cash and cash equivalents—end of period	174,371	138,313
Supplemental disclosure of cash flow information:
Cash paid for income taxes	27	10
Cash paid for interest	$ 558	$ 1,513