Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenues:
Product sales, net	$ 30,887	$ 35,144	$ 66,129	$ 73,557
License fees and service revenue	3,062	9,838	11,686	10,042
Total revenues	33,949	44,982	77,815	83,599
Operating costs and expenses:
Cost of product sales (excludes amortization and impairment charges of intangible assets)	5,609	5,990	11,212	13,061
Cost of service revenue	2,214	0	3,495	0
Selling, general and administrative	27,620	22,552	49,583	45,886
Research and development	14,281	9,558	29,744	25,409
Amortization and impairment charges of intangible assets	6,306	6,916	12,145	20,938
Total operating costs and expenses	56,030	45,016	106,179	105,294
Loss from operations	(22,081)	(34)	(28,364)	(21,695)
Other (expense) income:
Interest expense, net	(2,375)	(2,258)	(4,714)	(4,486)
Change in fair value of contingent consideration related to acquisitions	(285)	(146)	(1,327)	(646)
Other income (expense), net	340	69	618	(966)
Total other expenses	(2,320)	(2,335)	(5,423)	(6,098)
Loss before income taxes	(24,401)	(2,369)	(33,787)	(27,793)
Benefit (provision) for income taxes	106	23	171	(115)
Net loss	$ (24,295)	$ (2,346)	$ (33,616)	$ (27,908)
Net loss per share:
Basic and diluted ($ per share)	$ (0.35)	$ (0.04)	$ (0.50)	$ (0.43)
Weighted average shares outstanding:
Basic and diluted (shares)	68,575,021	65,466,004	67,146,188	65,167,162