Condensed Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Cash Flows From Operating Activities:
Net loss	$ (25,562)	$ (27,641)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	7,017	5,980
Stock-based compensation	2,462	2,571
Accretion of debt discount to interest expense on 2018 Convertible Notes (Note 11)	1,270	1,147
Amortization of deferred financing costs to interest expense on 2018 Convertible Notes (Note 11)	162	131
Bad debt (recovery) expense	44	(70)
Impairment of intangible assets (Note 3(e))	7,160	0
Non-cash foreign currency exchange loss	1,128	(364)
Research and development expense for the value of stock issued to TopoTarget in connection with milestone achievement	0	7,790
Change in fair value of contingent consideration related to acquisitions (Note 9)	500	724
Changes in operating assets and liabilities:
Accounts receivable, net	1,864	(4,454)
Other receivables	(2,399)	(647)
Inventories	121	600
Prepaid expenses	436	(14,484)
Deferred tax assets	(235)	(2)
Other assets	(404)	(861)
Accounts payable and other accrued obligations	(2,778)	(8,424)
Accrued payroll and benefits	(4,056)	(2,464)
Drug development liability	(666)	(236)
Deferred revenue	7,555	302
Deferred tax liability	239	955
Other long-term liabilities	855	(542)
Net cash used in operating activities	(5,287)	(39,989)
Cash Flows From Investing Activities:
Purchases of property and equipment	(78)	(320)
Net cash used in investing activities	(78)	(320)
Cash Flows From Financing Activities:
Proceeds from exercise of stock options	404	1,241
Purchase and retirement of restricted stock to satisfy employee tax liability at vesting	(262)	0
Net cash provided by financing activities	142	1,241
Effect of exchange rates on cash and equivalents	(1,354)	496
Net decrease in cash and cash equivalents	(6,577)	(38,572)
Cash and cash equivalents—beginning of period	129,942	156,306
Cash and cash equivalents—end of period	123,365	117,734
Supplemental disclosure of cash flow information:
Cash paid for income taxes	331	0
Cash paid for interest	$ 0	$ 0