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Stock-Based Compensation - Summary of Stock-Based Compensation Expense (Detail) (USD $)
In Thousands, unless otherwise specified
 3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Total share-based compensation $ 2,462us-gaap_AllocatedShareBasedCompensationExpense $ 2,851us-gaap_AllocatedShareBasedCompensationExpense
Research and development [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Total share-based compensation 433us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember		 444us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
Selling, general and administrative [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Total share-based compensation $ 2,029us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_SellingGeneralAndAdministrativeExpensesMember		 $ 2,407us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_SellingGeneralAndAdministrativeExpensesMember