License and Collaboration Agreements - License Agreements (Details) - Collaborative Arrangement, Transaction with Party to Collaborative Arrangement $ in Millions	Aug. 31, 2021 USD ($)
Combioxin
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payment	$ 10
Maximum aggregate milestone payments	105
AOP Orphan Pharmaceuticals GmbH
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payment	5
Maximum aggregate milestone payments	$ 25