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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
U.S. Federal statutory tax rate 21.00% 21.00% 21.00%
State income taxes, net of federal benefit (1.00%) 6.00% 2.00%
Tax effect on stock option exercises, net of forfeitures (44.00%) 4.00% 1.00%
R&D tax credits and Orphan Drug credits 31.00% (2.00%) (2.00%)
Limitation on executive compensation (60.00%) 9.00% 10.00%
Change in valuation allowance (40.00%) 9.00% 4.00%
Foreign rate differential 4.00% (1.00%) (2.00%)
Other (1.00%) 1.00% 1.00%
Effective tax rate (90.00%) 47.00% 35.00%