Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenue:
Total revenue	$ 195,892	$ 213,312	$ 236,707
Operating expenses:
Cost of product sales	47,891	42,374	33,714
Cost of royalty revenue	13,006	19,542	23,472
Research and development	36,810	44,419	32,607
Selling, general and administrative	76,370	60,509	71,416
Restructuring charge	0	7,911	0
Asset impairment charge	0	2,704	7,235
Change in fair value of contingent consideration	0	(763)	(7,377)
Legal settlement	0	0	1,650
Total operating expenses	174,077	176,696	162,717
Income from operations	21,815	36,616	73,990
Interest income	2,169	158	91
Interest expense	(2,686)	(2,736)	(1,136)
Other income	700	0	0
Total other income (expense), net	183	(2,578)	(1,045)
Income before income tax	21,998	34,038	72,945
Income tax provision	7,685	2,135	21,002
Net income	14,313	31,903
Net income	$ 14,313	$ 31,903	$ 51,943
Earnings per share:
Basic (in dollars per share)	$ 1.04	$ 2.16	$ 3.44
Diluted (in dollars per share)	$ 1.01	$ 2.09	$ 3.27
Weighted average number of common shares outstanding:
Basic (in shares)	13,754,516	14,768,625	15,102,890
Diluted (in shares)	14,138,733	15,278,651	15,908,211
Product sales
Revenue:
Total revenue	$ 73,989	$ 70,385	$ 45,327
Royalty revenue
Revenue:
Total revenue	112,903	142,927	153,880
License and other revenue
Revenue:
Total revenue	$ 9,000	$ 0	$ 37,500