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Organization and Business (Details)
1 Months Ended 3 Months Ended 12 Months Ended 36 Months Ended
Oct. 01, 2019
Sep. 30, 2019
Dec. 06, 2018
shares
Feb. 08, 2018
USD ($)
milestone_payment
Aug. 08, 2017
USD ($)
Nov. 16, 2016
USD ($)
milestone_payment
shares
Feb. 13, 2015
USD ($)
Oct. 31, 2018
shares
Mar. 31, 2017
USD ($)
Nov. 30, 2016
USD ($)
Jan. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Feb. 28, 2015
USD ($)
Dec. 31, 2019
USD ($)
product
Dec. 31, 2018
shares
Sep. 30, 2017
USD ($)
Mar. 31, 2015
USD ($)
Dec. 31, 2019
USD ($)
product
segment
person
shares
Dec. 31, 2018
USD ($)
shares
Dec. 31, 2017
USD ($)
shares
Dec. 31, 2015
USD ($)
Dec. 31, 2018
USD ($)
shares
Oct. 30, 2018
USD ($)
Sep. 20, 2017
Aug. 09, 2017
USD ($)
Aug. 09, 2016
USD ($)
Subsidiary, Sale of Stock [Line Items]                                                    
Number of products | product                           2       2                
Number of reportable segments | segment                                   1                
Stock repurchase program, authorized amount                                                 $ 100,000,000 $ 75,000,000.0
Shares of common stock repurchased (in shares) | shares                                   317,429 1,348,563 674,857   2,590,258        
Value of common stock repurchased                                   $ 17,961,000 $ 73,105,000 $ 43,792,000   $ 153,900,000        
Clinical development cost sharing percentage (in percentage)                                               50.00%    
Proceeds from upfront license agreement payment                               $ 12,500,000       $ 12,500,000            
Potential milestone payments on license agreement                                   10,000,000.0                
Teva Pharmaceuticals                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Upfront cash (payment) proceeds for license agreement                                   9,000,000                
Cephalon, Inc.                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Upfront cash (payment) proceeds for license agreement                 $ 25,000,000   $ 30,000,000   $ 30,000,000       $ 30,000,000       $ 30,000,000          
Licensing agreement, milestone proceeds                     $ 15,000,000 $ 15,000,000                            
Licensing agreement, proceeds from unique billing code                   $ 40,000,000                                
Maximum additional milestone payments             $ 25,000,000   $ 25,000,000                                  
Royalty payments if product is approved, percentage of net sales (in percentage) 30.00% 25.00%         20.00%     25.00%                                
Royalty revenue, percent of net sales threshold (in percentage) 32.00%                                                  
Eagle Biologics                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Payment for business acquisition           $ 27,209,000                                        
Shares issued to acquire business (in shares) | shares           40,200                                        
Business combination, stock consideration transferred, amount           $ 3,046,000                                        
Number of milestone payments | milestone_payment           4                                        
Milestone Payments | Eagle Biologics                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Contingent consideration liability       $ 48,000,000   $ 48,000,000                                        
Business combination, consideration transferred, including contingent consideration           $ 78,000,000                                        
Number of milestone payments | milestone_payment       4                                            
Payment of lump sum milestone arrangement       $ 15,000,000                                            
Amendment Credit Agreement | Minimum                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Commitment fee percentage (in percentage)         0.35%                                          
Amendment Credit Agreement | Maximum                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Commitment fee percentage (in percentage)         0.45%                                          
Revolving Credit Facility | Amendment Credit Agreement                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Credit agreement, term         3 years                                          
Line of credit facility, maximum borrowing capacity         $ 110,000,000                 $ 50,000,000       $ 50,000,000                
Letter of Credit | Amendment Credit Agreement                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Line of credit facility, maximum borrowing capacity         $ 5,000,000                                          
Line of Credit | Amendment Credit Agreement                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Credit agreement, term         3 years                                          
Line of credit facility, maximum borrowing capacity         $ 100,000,000                                          
Proceeds from line of credit         $ 50,000,000                 40,000,000                        
London Interbank Offered Rate (LIBOR) | Amendment Credit Agreement | Minimum                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Interest rate margin         2.25%                                          
London Interbank Offered Rate (LIBOR) | Amendment Credit Agreement | Maximum                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Interest rate margin         3.00%                                          
Prime Rate | Amendment Credit Agreement | Minimum                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Interest rate margin         1.25%                                          
Prime Rate | Amendment Credit Agreement | Maximum                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Interest rate margin         2.00%                                          
October 2018 Plan                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Stock repurchase program, authorized amount                                             $ 150,000,000      
Accelerated Share Repurchase                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Stock repurchase program, authorized amount                                             50,000,000      
Shares of common stock repurchased (in shares) | shares     297,146         702,988             1,000,134                      
Value of common stock repurchased                           $ 50,000,000                        
Additional Shares                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Stock repurchase program, authorized amount                                             $ 100,000,000      
UNITED STATES                                                    
Subsidiary, Sale of Stock [Line Items]                                                    
Number of people treated for accidental exposure to organophosphate pesticides yearly | person                                   2,700