Balance Sheet Accounts - Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Balance Sheet Related Disclosures [Abstract]
Royalties payable to commercial partners	$ 6,989	$ 9,068
Accrued research & development	1,816	3,528
Accrued professional fees	1,504	2,094
Accrued salary and other compensation	2,024	6,003
Accrued product costs	2,154	2,856
Accrued other	912	1,688
Total Accrued expenses	$ 15,399	$ 25,237