Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Income Statement [Abstract]
Net revenues	$ 130,432	$ 138,438
Cost of product sales	59,697	77,220
Operating expenses:
Selling, general and administrative	79,831	96,472
Research and development	38,820	49,008
Restructuring charges	2,151	2,536
Total operating expenses	120,802	148,016
Loss from operations	(50,067)	(86,798)
Interest expense, net	(50,498)	(39,037)
Interest expense, net	(4,333)	0
Other expense, net	(1,830)	(292)
Loss before provision for income taxes	(106,728)	(126,127)
Provision for income taxes	(1,599)	(583)
Net loss	$ (108,327)	$ (126,710)
Net loss per common share—basic and diluted (in dollars per share)	$ (5.76)	$ (6.81)
Weighted-average common shares outstanding—basic and diluted (in shares)	18,812	18,616