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    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

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        <entityName>MESIROW FINANCIAL HOLDINGS INC</entityName>
        <issuerAddress>
            <street1>353 N CLARK ST</street1>
            <city>CHICAGO</city>
            <stateOrCountry>IL</stateOrCountry>
            <stateOrCountryDescription>ILLINOIS</stateOrCountryDescription>
            <zipCode>60654</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>3125956000</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Mesirow Holding Company, Inc.</previousName>
            <previousName>Mesirow Financial Corporation</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

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                <middleName>C.</middleName>
                <lastName>Tyree</lastName>
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                <street1>353 North Clark Street</street1>
                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
                <stateOrCountryDescription>ILLINOIS</stateOrCountryDescription>
                <zipCode>60654</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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            <relatedPersonName>
                <firstName>Thomas</firstName>
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                <lastName>Galuhn</lastName>
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                <city>Chicago</city>
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                <relationship>Director</relationship>
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                <middleName>A.</middleName>
                <lastName>Golman</lastName>
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                <city>Chicago</city>
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                <zipCode>60654</zipCode>
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            <relatedPersonRelationshipList>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>Ruth</firstName>
                <middleName>C.</middleName>
                <lastName>Hannenberg</lastName>
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                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
                <stateOrCountryDescription>ILLINOIS</stateOrCountryDescription>
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                <relationship>Director</relationship>
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            <relatedPersonName>
                <firstName>Martin</firstName>
                <middleName>B.</middleName>
                <lastName>Kaplan</lastName>
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            <relatedPersonAddress>
                <street1>353 North Clark Street</street1>
                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
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                <zipCode>60654</zipCode>
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                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gerald</firstName>
                <middleName>J.</middleName>
                <lastName>Levin</lastName>
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                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
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                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
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                <middleName>S.</middleName>
                <lastName>Price</lastName>
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                <city>Chicago</city>
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                <zipCode>60654</zipCode>
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                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Howard</firstName>
                <middleName>M.</middleName>
                <lastName>Rossman</lastName>
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                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
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                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marc</firstName>
                <middleName>E.</middleName>
                <lastName>Sacks</lastName>
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                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
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                <relationship>Director</relationship>
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                <firstName>Julie</firstName>
                <middleName>E.</middleName>
                <lastName>Vander Weele</lastName>
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                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
                <stateOrCountryDescription>ILLINOIS</stateOrCountryDescription>
                <zipCode>60654</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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                <firstName>Stephen</firstName>
                <middleName>C.</middleName>
                <lastName>Vogt</lastName>
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                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
                <stateOrCountryDescription>ILLINOIS</stateOrCountryDescription>
                <zipCode>60654</zipCode>
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            <relatedPersonRelationshipList>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bruce</firstName>
                <middleName>J.</middleName>
                <lastName>Young</lastName>
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            <relatedPersonAddress>
                <street1>353 North Clark Street</street1>
                <city>Chicago</city>
                <stateOrCountry>IL</stateOrCountry>
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                <zipCode>60654</zipCode>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dennis</firstName>
                <middleName>B.</middleName>
                <lastName>Black</lastName>
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                <street1>353 North Clark Street</street1>
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                <stateOrCountry>IL</stateOrCountry>
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                <zipCode>60654</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kristie</firstName>
                <middleName>P.</middleName>
                <lastName>Paskvan</lastName>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Over $100,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-09-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
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        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
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        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
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        <minimumInvestmentAccepted>15000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>23494119</totalOfferingAmount>
            <totalAmountSold>23494119</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
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        <investors>
            <hasNonAccreditedInvestors>true</hasNonAccreditedInvestors>
            <numberNonAccreditedInvestors>15</numberNonAccreditedInvestors>
            <totalNumberAlreadyInvested>133</totalNumberAlreadyInvested>
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        <salesCommissionsFindersFees>
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                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse>N/A</clarificationOfResponse>
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        <useOfProceeds>
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                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>N/A</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>MESIROW FINANCIAL HOLDINGS INC</issuerName>
                <signatureName>/s/ Dennis B. Black</signatureName>
                <nameOfSigner>Dennis B. Black</nameOfSigner>
                <signatureTitle>General Counsel</signatureTitle>
                <signatureDate>2010-09-27</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
