| AB VARIABLE PRODUCTS SERIES FUND, INC. |
| -AB Intermediate Bond Portfolio |
| (the "Portfolio") |
Supplement dated October 6, 2021 to the Portfolio's Prospectuses and Summary Prospectuses dated May 1, 2021.
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The following replaces the chart under the heading "Portfolio Managers" in the Prospectuses and Summary Prospectuses for the Portfolio.
PORTFOLIO MANAGERS
The following table lists the persons responsible for day-to-day management of the Portfolio's portfolio:
| Employee | Length of Service | Title |
| Michael Canter | Since 2016 | Senior Vice President of the Adviser |
| Janaki Rao | Since 2019 | Senior Vice President of the Adviser |
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The following replaces certain information under the heading "Management of the Portfolio - Portfolio Managers" in the Prospectuses.
|
Employee; Length of Service; Title |
Principal Occupation |
| Michael Canter; since 2016; Senior Vice President of the Adviser | Senior Vice President of the Adviser, with which he has been associated in a substantially similar capacity to his current position since prior to 2016. |
| Janaki Rao; since 2019; Senior Vice President of the Adviser | Senior Vice President of the Adviser, with which he has been associated in a substantially similar capacity to his current position since prior to 2016. |
The Statement of Additional Information is revised, as applicable, to incorporate changes conforming to this Supplement.
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This Supplement should be read in conjunction with the Prospectuses for the Portfolio.
You should retain this Supplement with your Prospectus(es) for future reference.
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