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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 LyOkh4syZ5FNQtv3g4pG1Q==

<SEC-DOCUMENT>0000823560-04-000014.txt : 20040402
<SEC-HEADER>0000823560-04-000014.hdr.sgml : 20040402
<ACCEPTANCE-DATETIME>20040402154255
ACCESSION NUMBER:		0000823560-04-000014
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040331
FILED AS OF DATE:		20040402

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDICAL TECHNOLOGY SYSTEMS INC /DE/
		CENTRAL INDEX KEY:			0000823560
		STANDARD INDUSTRIAL CLASSIFICATION:	GENERAL INDUSTRIAL MACHINERY & EQUIPMENT [3560]
		IRS NUMBER:				592740462
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0331

	BUSINESS ADDRESS:	
		STREET 1:		12920 AUTOMOBILE BLVD
		CITY:			CLEARWATER
		STATE:			FL
		ZIP:			34622-4734
		BUSINESS PHONE:		7275766311

	MAIL ADDRESS:	
		STREET 1:		12920 AUTOMOBILE BLVD
		CITY:			CLEARWATER
		STATE:			FL
		ZIP:			33762

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			NEWMAN FRANK A
		CENTRAL INDEX KEY:			0001196750

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-31578
		FILM NUMBER:		04713808

	BUSINESS ADDRESS:	
		STREET 1:		C/O JABIL CIRCUIT INC
		STREET 2:		10560 DR. MARTIN LUTHER KING JR. ST N
		CITY:			ST PETERSBURG
		STATE:			FL
		ZIP:			33716-3718
		BUSINESS PHONE:		727-803-3309

	MAIL ADDRESS:	
		STREET 1:		10560 DR. MARTIN LUTHER KING JR. ST N
		CITY:			ST PETERSBURG
		STATE:			FL
		ZIP:			33716-3718
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>new25.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-03-31</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000823560</issuerCik>
        <issuerName>MEDICAL TECHNOLOGY SYSTEMS INC /DE/</issuerName>
        <issuerTradingSymbol>(MPP)</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001196750</rptOwnerCik>
            <rptOwnerName>NEWMAN FRANK A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1></rptOwnerStreet1>
            <rptOwnerStreet2>12920 AUTOMOBILE BLVD.</rptOwnerStreet2>
            <rptOwnerCity>CLEARWATER</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33762-</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>12.45</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2004-03-31</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2004-03-31</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2004-09-30</value>
            </exerciseDate>
            <expirationDate>
                <value>2014-03-31</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>3000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Newman, Frank</signatureName>
        <signatureDate>2004-04-02</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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