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Shareholders' Equity - Warrants Accounted for As Liabilities (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended
Aug. 31, 2016
Feb. 28, 2015
Feb. 28, 2011
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2016
Aug. 12, 2016
Feb. 24, 2016
Dec. 31, 2015
Class of Stock [Line Items]                      
Price of common stock (in USD per share)       $ 0.85   $ 0.85   $ 2.05      
Warrant liability       $ 27,862 $ 1,063,335 $ 27,862 $ 1,063,335 $ 573,560     $ 1,958,775
Financing expense       $ 0 16,595 $ 0 31,231        
2016 Underwritten Public Offering | Base Warrant | Maxim Group, LLC                      
Class of Stock [Line Items]                      
Warrants to purchase preferred stock (in shares) 881,250                    
Exercise price of warrants (in USD per share) $ 7.68                    
Life of warrants           5 years          
Proceeds from issuance of warrants $ 2,284,395                    
Warrant | 2011 Common Stock Private Placement                      
Class of Stock [Line Items]                      
Warrants to purchase preferred stock (in shares)     70,467                
Exercise price of warrants (in USD per share)   $ 57.60 $ 90.00                
Life of warrants     5 years                
Exercise price of warrants, decrease threshold (less than) (in USD per share)     $ 62.00                
Remaining warrants to purchase common stock (in shares)   91,670               91,670  
Warrant | 2015 Underwritten Public Offering                      
Class of Stock [Line Items]                      
Warrants to purchase preferred stock (in shares)   466,369                  
Exercise price of warrants (in USD per share)   $ 26.40           $ 20.00      
Life of warrants   5 years                  
Remaining warrants to purchase common stock (in shares)       466,369   466,369          
Warrant liability       $ 7,302   $ 7,302          
Warrant | 2015 Underwritten Public Offering | Binomial Lattice Simulation                      
Class of Stock [Line Items]                      
Dividend yield rate   0.00%       0.00%          
Expected volatility rate   97.00%       66.00%          
Risk-free interest rate   1.53%       1.47%          
Expected life of warrants   5 years       2 years 7 months 22 days          
Valuation of warrants   $ 4,197,375                  
Other income       $ 46,331 $ 445,660 $ 69,650 $ 926,671        
Warrant | 2016 Underwritten Public Offering | Maxim Group, LLC                      
Class of Stock [Line Items]                      
Warrants to purchase preferred stock (in shares) 993,115     993,115   993,115          
Exercise price of warrants (in USD per share)       $ 0.02   $ 0.02     $ 2.30    
Warrant liability       $ 20,560   $ 20,560          
Income recorded in adjustment of warrants       $ 396,591   $ 476,048