Consolidated Statements of Shareholders' Equity - USD ($)	Total	Common Stock	Additional Paid-in Capital	Accumulated Deficit
Beginning Balance at Dec. 31, 2013	$ 26,473,594	$ 144	$ 78,442,843	$ (51,969,393)
Beginning balance (in shares) at Dec. 31, 2013		1,438,520
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options	$ 1,045,000	$ 2	1,044,998
Exercise of stock options (in shares)	15,601	23,750
Cashless exercise of stock options		$ 0	0
Cashless exercise of stock options (in shares)		712
Stock based compensation	$ 654,260	$ 0	654,260
Common stock issued through controlled equity offering, in 2016 at an average price of $10.00 per share, and 2014 at $36.80 per share	4,496,322	$ 13	4,496,309
Common stock issued through controlled equity offering, in 2016 at an average price of $10.00 per share, and 2014 at $36.80 per share (in shares)		127,103
Net loss	(9,377,533)			(9,377,533)
Ending Balance at Dec. 31, 2014	23,291,643	$ 159	84,638,410	(61,346,926)
Ending balance (in shares) at Dec. 31, 2014		1,590,085
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options	$ 6,750	$ 0	6,750
Exercise of stock options (in shares)	1,250	625
Common stock and warrants issued for cash during August 2016 and February 2015, at $6.40 and $24.00 per unit, respectively, net of offering costs	$ 10,296,689	$ 66	10,296,623
Common stock and warrants issued for cash during August 2016 and February 2015, at $6.40 and $24.00 per unit, respectively, net of offering costs (in shares)		666,250
Cashless exercise of stock options		$ 0	0
Cashless exercise of stock options (in shares)		258
Stock based compensation	916,028		916,028
Stock based compensation (in shares)		500
Net loss	(12,790,814)			(12,790,814)
Ending Balance at Dec. 31, 2015	$ 21,720,296	$ 225	95,857,811	(74,137,740)
Ending balance (in shares) at Dec. 31, 2015		2,257,718
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock options (in shares)	0
Common stock and warrants issued for cash during August 2016 and February 2015, at $6.40 and $24.00 per unit, respectively, net of offering costs	$ 4,625,955	$ 111	4,625,844
Common stock and warrants issued for cash during August 2016 and February 2015, at $6.40 and $24.00 per unit, respectively, net of offering costs (in shares)		1,110,000
Stock based compensation	1,228,987	$ 0	1,228,987
Stock based compensation (in shares)		0
Common stock issued through controlled equity offering, in 2016 at an average price of $10.00 per share, and 2014 at $36.80 per share	$ 642,210	$ 8	642,202
Common stock issued through controlled equity offering, in 2016 at an average price of $10.00 per share, and 2014 at $36.80 per share (in shares)	77,141	77,141
Net loss	$ (22,085,702)			(22,085,702)
Ending Balance at Dec. 31, 2016	$ 6,131,746	$ 344	$ 102,354,844	$ (96,223,442)
Ending balance (in shares) at Dec. 31, 2016		3,444,859