Adjustments for Share-based Compensation Value

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Term of supply agreement extended.

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Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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Aggregate number of common shares reserved for future issuance.

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Maximum term of the deferred compensation arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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- Definition

Unrecognized cost of unvested options awarded to employees as compensation.

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The total recognized tax benefit related to compensation cost for equity-based payment arrangements recognized in income during the period.

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Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement.

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Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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- Definition

The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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- Definition

The number of equity-based payment instruments, excluding stock (or unit) options, that vested during the reporting period.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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- Definition

The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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- Definition

Gross number of share options (or share units) granted during the period.

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No definition available.

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- Definition

The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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- Definition

Percentage of vesting of share-based compensation awards.

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Fair value of options vested. Excludes equity instruments other than options, for example, but not limited to, share units, stock appreciation rights, restricted stock.

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Total number of shares issued during the period, including shares forfeited, as a result of Restricted Stock Awards.

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Number of share options (or share units) exercised during the current period.

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Stock-based Compensation - Additional Information (Detail) - USD ($)			3 Months Ended		12 Months Ended
	Feb. 07, 2018	Jan. 08, 2018	Mar. 31, 2018	Dec. 31, 2015	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation expense, shares					66,234	42,203	13,106
Stock options granted					680,400
Cash received from option exercised							$ 82,000
Stock option exercised					0	0
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition					2 years 1 month 6 days
Stock-based compensation expense					$ 1,469,000	$ 1,201,000	$ 1,750,000
Tax benefit from stock-based compensation expense recognized					0	$ 0
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized					300,000
Total fair value of shares vested during the years					$ 300,000
Subsequent Event [Member] \| Merck KGaA, Darmstandt [Member] \| Germany [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Term of supply agreement extended		4 years 6 months
Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock options granted					680,400	657,500	387,000
Weighted-average grant date fair values of options granted					$ 2.43	$ 4.66	$ 4.38
Non-Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock options granted					0	0
Weighted-average grant date fair values of options granted							$ 4.52
Reduction of stock-based compensation expense					$ 100,000	$ 100,000
Stock-based compensation expense							$ 1,100,000
Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Deferred compensation arrangement with individual, maximum contractual term					10 years
Total unrecognized compensation costs related to non-vested options					$ 2,500,000
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition					2 years 8 months 12 days
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized					$ 2,500,000
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, award vesting period					2 years
Number of shares, awarded					118,934
Shares, vested					40,933
Restricted Stock [Member] \| Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, award vesting period					1 year
Restricted Stock [Member] \| Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, award vesting period					4 years
Performance-Based Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares, awarded					186,000	0
Shares, vested					0
Performance-Based Restricted Stock Units [Member] \| Board of Director [Member] \| Scenario, Forecast [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense			$ 200,000
Performance-Based Restricted Stock Units [Member] \| Board of Director [Member] \| Subsequent Event [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares, vested	27,800
2008 [Member] \| Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, capital shares reserved for future issuance								1,250,000
Share-based compensation, vesting percentage								25.00%
Share-based compensation arrangement by share-based payment award, award vesting period					48 months
2015 Plan [Member] \| Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, capital shares reserved for future issuance				1,000,000			1,000,000
Share-based compensation, vesting percentage				6.25%			25.00%
Share-based compensation arrangement by share-based payment award, award vesting period					48 months
2015 Plan [Member] \| Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, capital shares reserved for future issuance				200,000			200,000
Amended and Restated 2015 Plan [Member] \| Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation, available for future grant					1,861,142
Prior To 2006 [Member] \| Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Deferred compensation arrangement with individual, maximum contractual term					10 years
2006 [Member] \| Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Deferred compensation arrangement with individual, maximum contractual term					7 years