Shareholders' Equity - Additional Information (Detail) (USD $)	0 Months Ended		3 Months Ended	12 Months Ended					12 Months Ended				12 Months Ended					12 Months Ended	0 Months Ended	12 Months Ended			0 Months Ended
	Sep. 12, 2013	Sep. 20, 2011	Jun. 30, 2012	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Sep. 30, 2013	Mar. 12, 2002	Dec. 31, 2011 Restricted Stock [Member]	Dec. 31, 2013 Warrant [Member]	Dec. 31, 2012 Warrant [Member]	Dec. 31, 2011 Warrant [Member]	Dec. 31, 2011 Warrant [Member] Exercise Price 10.80 Per Share, Second Offering [Member]	Dec. 31, 2011 Warrant [Member] Exercise Price 12.16 Per Share, Third Offering [Member]	Mar. 12, 2002 Conversion Threshold, 15% [Member]	Mar. 12, 2002 Conversion Threshold, Greater than 15% and Less than 50% [Member]	Nov. 29, 2010 Conversion Threshold, Revised, 4.99% [Member]	Dec. 31, 2013 Series B Convertible Preferred Stock [Member] Vote	Sep. 24, 2012 Series C Preferred Stock [Member]	Dec. 31, 2013 Series C Preferred Stock [Member]	Dec. 31, 2012 Series C Preferred Stock [Member]	Dec. 31, 2013 Series C Preferred Stock [Member] Maximum [Member]	Nov. 14, 2013 Series E Convertible Preferred Stock [Member]	Dec. 31, 2013 Series E Convertible Preferred Stock [Member]	Dec. 31, 2013 Series D Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, authorized (in shares)				1,000,000	1,000,000
Preferred stock, par value (in dollars per share)				$ 0.01	$ 0.01																			$ 100
Convertible preferred stock, shares issued upon conversion																		20
Preferred stock, shares outstanding (in shares)																		130		550			22,740	0
Preferred stock, liquidation preference per share																		$ 100
Votes per stock																		1
Preferred stock redemption price per share													$ 10.80							$ 1,000
Preferred stock convertible to common stock, conversion price per share																				$ 28.00
Average percentage of closing price																				100.00%
Consecutive trading days required for conversion																				3 days
Stock issued during period, shares, conversion of convertible securities													301,417	56,325					50		50	294,045	142,125
Dividend payable, preferred stock																				5.00%
Preferred stock, redemption amount																			$ 50,000
Dividends declared, share, preferred stock purchase right for outstanding common stock								1
Preferred stock, conversion trigger, percentage ownership change															15.00%	50.00%	4.99%
Preferred stock, conversion amount, per one thousandth of a Share																									$ 30
Exercise Price				12.16			12.16			12.16	12.16	12.16		12.16
Minimum ownership percentage for change				5.00%
Period for ownership change				3 years
Right plan expiration date		Mar. 12, 2012		Jul. 03, 2013
Right plan extended expiration date		Jul. 03, 2013		Jul. 03, 2016
Share based compensation expense, shares			22,059	28,083
Stock issued during period, shares as a part of consideration for the acquisition of Molecular Profiles	1,051,323
Stock issued during period, shares, restricted stock award, net of forfeitures									4,360
Shares paid for tax withholding for share based compensation									4,556
Proceeds from exercise of warrants				$ 0	$ 0	$ 653,299
Conversion of preferred stock, shares													465,825	59,975