X0202 4 2006-12-22 0 0000821995 COLUMBIA LABORATORIES INC CBRX 0000808722 KNOTT DAVID M 485 UNDERHILL BLVD STE 205 SYOSSET NY 11791-3419 0 0 1 0 Common Stock 995780 I By Knott Partners, L.P. Common Stock 747200 I By Shoshone Partners, L.P. Common Stock 600 I By Wife Common Stock 1754270 I By Knott Partners Offshore Master Fund, L.P. Common Stock 216600 I By Managed Accounts Common Stock 3920 D Warrant to purchase Common Stock 5.39 2006-09-13 2011-09-13 Common Stock 75120 75120 I By Knott Partners, L.P. Warrant to purchase Common Stock 5.39 2006-09-13 2011-09-13 Common Stock 80750 80750 I By Shoshone Partners, L.P. Warrant to purchase Common Stock 5.39 2006-09-13 2011-09-13 Common Stock 202212 202212 I By Knott Partners Offshore Master Fund, L.P. Warrant to purchase Common Stock 5.39 2006-09-13 2011-09-13 Common Stock 13175 13175 I By Managed Accounts Series C Preferred Stock 3.50 Common Stock 339428 339428 I By Knott Partners, L.P. Series C Preferred Stock 3.50 Common Stock 32000 32000 D Series E Preferred Stock 2.00 Common Stock 63000 63000 I By Managed Accounts Series E Preferred Stock 2.00 Common Stock 399000 399000 I By Knott Partners, L.P. Series E Preferred Stock 2.00 Common Stock 479000 479000 I By Knott Partners Offshore Master Fund L.P. Series E Preferred Stock 2.00 Common Stock 259000 259000 I By Shoshone Partners, L.P. Convertible Subordinated Notes due 2011 5.25 2006-12-22 4 P 0 136000 A 2011-12-31 Common Stock 25905 136000 I By Knott Partners, L.P. Convertible Subordinated Notes due 2011 5.25 2006-12-22 4 P 0 628000 A 2011-12-31 Common Stock 119619 628000 I By Shoshone Partners, L.P. Convertible Subordinated Notes due 2011 5.25 2006-12-22 4 P 0 3940000 A 2011-12-31 Common Stock 750476 3940000 I by Knott Partners Offshore Master Fund, L.P. Convertible Subordinated Notes due 2011 5.25 2006-12-22 4 P 0 83000 A 2011-12-31 Common Stock 15810 83000 I By Mulsanne Partners, L.P. Convertible Subordinated Notes due 2011 5.25 2006-12-22 4 P 0 213000 A 2011-12-31 Common Stock 40571 213000 I By Managed Accounts Warrants to Purchase Common Stock 5.50 2006-12-22 4 P 0 7771 A 2011-12-21 Common Stock 7771 7771 I By Knott Partners, L.P. Warrants to Purchase Common Stock 5.50 2006-12-22 4 P 0 35886 A 2011-12-21 Common Stock 35886 35886 I By Shoshone Partners, L.P. Warrants to Purchase Common Stock 5.50 2006-12-22 4 P 0 225143 A 2011-12-21 Common Stock 225143 225143 I by Knott Partners Offshore Master Fund, L.P. Warrants to Purchase Common Stock 5.50 2006-12-22 4 P 0 4743 A 2011-12-21 Common Stock 4743 4743 I By Mulsanne Partners, L.P. Warrants to Purchase Common Stock 5.50 2006-12-22 4 P 0 12172 A 2011-12-21 Common Stock 12172 12172 I By Managed Accounts The Reporting Person is the managing member of Knott Partners Management, LLC, which is (i) the sole general partner of Shoshone Partners, L.P., Mulsanne Partners, L.P. and Knott Partners Offshore Master Fund LP., and (ii) the managing general partner of Knott Partners, L.P. This entry represents securities of the issuer held by institutional managed accounts for which Dorset Management Corporation provides investment management services (the "Managed Accounts"). As a result of the Reporting Person's interests in Knott Partners Management, LLC and in Dorset Management Corporation, the Reporting Person has investment discretion and control of the securities in this entry. The Reporting Person may be deemed to beneficially own an indirect pecuniary interest in securities in this entry as a result of a performance related fee. Except with respect to Knott Partners, L.P. and Shoshone Partners, L.P., in which the Reporting Person owns a beneficial interest, the Reporting Person disclaims beneficial ownership therein except to the extent ultimately realized. Each of Knott Partners, L.P., Shoshone Partners, L.P., Mulsanne Partners, L.P., Knott Partners Offshore Master Fund, L.P. and the Managed Accounts disclaims beneficial ownership of securities reported as owned by any other party. These shares are currently convertible. These shares do not expire. The derivative securities reported in this entry are exercisable at any time but only to the extent that after giving effect to such exercise the holder thereof, together with such holder's affiliates, would not beneficially own in excess of 9.99% of the shares of Common Stock outstanding immediately after giving effect to such exercise. The aggregate purchase price paid for the Convertible Subordinated Notes due 2011 and the Warrants reported in the entries bearing this footnote number was $136,000. The aggregate purchase price paid for the Convertible Subordinated Notes due 2011 and the Warrants reported in the entries bearing this footnote number was $628,000. The aggregate purchase price paid for the Convertible Subordinated Notes due 2011 and the Warrants reported in the entries bearing this footnote number was $3,940,000. The aggregate purchase price paid for the Convertible Subordinated Notes due 2011 and the Warrants reported in the entries bearing this footnote number was $83,000. The aggregate purchase price paid for the Convertible Subordinated Notes due 2011 and the Warrants reported in the entries bearing this footnote number was $213,000 The derivative securities reported in this entry are exercisable at any time from and after June 20, 2007 but only to the extent that after giving effect to such exercise the holder thereof, together with such holder's affiliates, would not beneficially own in excess of 9.99% of the shares of Common Stock outstanding immediately after giving effect to such exercise. /s/ David M. Knott 2007-01-10