-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, InUh3pyIkQjjh9OXVnLbeM0PLNcJ9Fp+lDo0bA/EQb5qfLETfUJU7ygs9as907sC cILbW0gcWbu3FqfGU+8Y0Q== 0001144204-08-020608.txt : 20080404 0001144204-08-020608.hdr.sgml : 20080404 20080404130240 ACCESSION NUMBER: 0001144204-08-020608 CONFORMED SUBMISSION TYPE: 424B3 PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20080404 DATE AS OF CHANGE: 20080404 FILER: COMPANY DATA: COMPANY CONFORMED NAME: QUANTRX BIOMEDICAL CORP CENTRAL INDEX KEY: 0000820608 STANDARD INDUSTRIAL CLASSIFICATION: SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841] IRS NUMBER: 330202574 STATE OF INCORPORATION: NV FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 424B3 SEC ACT: 1933 Act SEC FILE NUMBER: 333-142130 FILM NUMBER: 08739762 BUSINESS ADDRESS: STREET 1: 100 SOUTH MAIN STREET STREET 2: SUITE 300 CITY: DOYLESTOWN STATE: PA ZIP: 18901 BUSINESS PHONE: 267-880-1595 MAIL ADDRESS: STREET 1: 100 SOUTH MAIN STREET STREET 2: SUITE 300 CITY: DOYLESTOWN STATE: PA ZIP: 18901 FORMER COMPANY: FORMER CONFORMED NAME: AFEM MEDICAL CORP DATE OF NAME CHANGE: 19970722 FORMER COMPANY: FORMER CONFORMED NAME: XTRAMEDICS INC /NV/ DATE OF NAME CHANGE: 19920703 424B3 1 v109772_424b3.htm
Filed Pursuant to Rule 424(b)(3)
File Number 333-142130

PROSPECTUS SUPPLEMENT NO. 7

Prospectus Supplement No. 7
to Prospectus dated June 22, 2007
as supplemented by
Prospectus Supplement No. 1 dated July 13, 2007
and
Prospectus Supplement No. 2 dated August 20, 2007
and
Prospectus Supplement No. 3 dated October 25, 2007
and
Prospectus Supplement No. 4 dated November 19, 2007
and
Prospectus Supplement No. 5 dated January 30, 2008
And
Prospectus Supplement No. 6 dated March 5, 2008

QUANTRX BIOMEDICAL CORPORATION

This Prospectus Supplement No. 7 supplements our prospectus dated June 22, 2007, as supplemented by Prospectus Supplement No. 1 dated July 13, 2007, Prospectus Supplement No. 2 dated August 20, 2007, Prospectus Supplement No. 3 dated October 25, 2007, Prospectus Supplement No. 4 dated November 19, 2007, Prospectus Supplement No. 5 dated January 30, 2008, and Prospectus No. 6 dated March 5, 2008. The shares of our common stock that are the subject of the prospectus have been registered to permit their resale to the public by the selling stockholders named in the prospectus. We are not selling any shares of common stock in this offering and therefore will not receive any proceeds from such offering, except upon the exercise of warrants.
 
Our common stock is quoted on the Over-The-Counter Bulletin Board under the symbol QTXB.OB. The high and low prices for shares of our common stock on April 3, 2008, were $0.95 and $0.93 per share, respectively, based upon bids that represent prices quoted by broker-dealers on the OTC Bulletin Board.

This Prospectus Supplement includes the Annual Report on Form 10-KSB filed by us with the U.S. Securities and Exchange Commission on March 31, 2008.

YOU SHOULD READ THE PROSPECTUS AND THIS PROSPECTUS SUPPLEMENT NO. 7 CAREFULLY BEFORE YOU INVEST, INCLUDING THE RISK FACTORS THAT BEGIN ON PAGE 4 OF THE PROSPECTUS.

NEITHER THE U.S. SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS SUPPLEMENT IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

The date of this Prospectus Supplement is April 4, 2008.
 
 
 

 
  
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 10-KSB

x
ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
   
For the fiscal year ended December 31, 2007
   
o
TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
 
For the transition period from __________ to __________

Commission File Number: 000-17119

QUANTRX BIOMEDICAL CORPORATION
(Name of small business issuer in its charter)

Nevada
(State or other jurisdiction of
incorporation or organization)
33-0202574
(IRS Employer
Identification No.)

100 South Main Street, Suite 300, Doylestown, Pennsylvania 18901
(Address of principal executive offices) (Zip code)

(267) 880-1595
(Issuer’s telephone number)

Securities registered under Section 12(b) of the Exchange Act:

None

Securities Registered Pursuant to Section 12(g) of the Exchange Act

Common Stock, $0.01 par value
(Title of class)

Check whether the issuer (1) filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. x Yes     o No

Check if there is no disclosure of delinquent filers in response to Item 405 of Regulation S-B contained in this form, and no disclosure will be contained, to the best of registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-KSB or any amendment to this Form 10-KSB. o
 
Indicate by a check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes o No x

State issuer’s revenues for its most recent fiscal year: $747,119

At March 17, 2008 the aggregate market value of the common stock held by non-affiliates of the issuer was approximately $28,683,303 based upon the closing price of $0.82 reported for such date.

The number of shares outstanding of the issuer’s common stock as of March 17, 2008 was 41,699,681.

Transitional Small Business Disclosure Form (Check one): Yes o No x



TABLE OF CONTENTS
 
PART I
 
 
 
 
Item 1.
 
Description of Business
 
3
Item 2.
 
Description of Property
 
18
Item 3.
 
Legal Proceedings
 
18
Item 4.
 
Submission of Matters to a Vote of Security Holders
 
18
PART II
 
 
 
 
Item 5.
 
Market for Common Equity and Related Stockholder Matters
 
18
Item 6.
 
Management’s Discussion and Analysis
 
20
Item 7.
 
Financial Statements
 
26
Item 8.
 
Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
 
26
Item 8A.
 
Controls and Procedures
 
26
Item 8B.
 
Other Information
 
27
PART III
 
 
 
 
Item 9.
 
Directors, Executive Officers, Promoters, Control Persons and Corporate Governance; Compliance with Section 16(a) of the Exchange Act
 
28
Item 10.
 
Executive Compensation
 
31
Item 11.
 
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
 
33
Item 12.
 
Certain Relationships and Related Transactions
 
34
Item 13.
 
Exhibits
 
35
Item 14.
 
Principal Accounting Fees and Services
 
37
SIGNATURES
 
 
 
38

2


CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING INFORMATION

THIS ANNUAL REPORT ON FORM 10-KSB, INCLUDING EXHIBITS THERETO, CONTAINS FORWARD-LOOKING STATEMENTS WITHIN THE MEANING OF SECTION 27A OF THE SECURITIES ACT OF 1933, AS AMENDED, AND SECTION 21E OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. THESE FORWARD-LOOKING STATEMENTS ARE TYPICALLY IDENTIFIED BY THE WORDS “ANTICIPATES”, “BELIEVES”, “EXPECTS”, “INTENDS”, “FORECASTS”, “PLANS”, “FUTURE”, “STRATEGY”, OR WORDS OF SIMILAR MEANING. VARIOUS FACTORS COULD CAUSE ACTUAL RESULTS TO DIFFER MATERIALLY FROM THOSE EXPRESSED IN THE FORWARD-LOOKING STATEMENTS, INCLUDING THOSE DESCRIBED IN “RISK FACTORS” ON PAGE SEVEN HEREOF. THE COMPANY ASSUMES NO OBLIGATIONS TO UPDATE THESE FORWARD-LOOKING STATEMENTS TO REFLECT ACTUAL RESULTS, CHANGES IN ASSUMPTIONS, OR CHANGES IN OTHER FACTORS, EXCEPT AS REQUIRED BY LAW.
 
PART I
 
As used in this annual report on Form 10-KSB, “we,” “us,” “our,” “QuantRx” and “Company” refer to QuantRx Biomedical Corporation and its subsidiary, unless the context otherwise requires.
 
Item 1. Description of Business 
 
Overview
 
QuantRx Biomedical Corporation is a broad-based diagnostics company focused on the development and commercialization of innovative diagnostic products based on its patented technology platforms for the worldwide healthcare industry. The Company’s strategy is to commercialize its products through partners or distributors, contracting the manufacturing to third party partners while maintaining control over the manufacturing process.
 
QuantRx was incorporated December 5, 1986 under the laws of the state of Nevada. In April 2007, QuantRx increased its ownership in FluoroPharma, Inc., a development-stage molecular imaging company, to 57.78% of outstanding capital stock, resulting in its consolidation effective April 1, 2007. The investment in FluoroPharma is intended to strategically expand QuantRx’s diagnostic platforms.
 
Our Business
 
The Company’s technologies target significant market opportunities through the following platforms:
 
Lateral Flow Diagnostics
 
 
·
RapidSense® point-of-care testing products based on QuantRx core intellectual property related to lateral flow techniques for the consumer and healthcare professional markets.
 
Molecular Imaging 
 
 
·
Molecular imaging agents for Positron Emission Tomography (PET) and fluorescence imaging, with initial application in cardiovascular disease, addressing significant unmet medical needs by providing clinicians with important tools for early discovery and assessment.
 
3

 
Genomic Testing (through our affiliate, Genomics USA)
 
 
·
Single Nucleotide Polymorphism (SNP) chips; genome-based diagnostic chips for the laboratory and healthcare professional markets.
 
PAD/Health and Wellness
 
 
·
PAD technology for diagnosis and treatment of hemorrhoids, minor vaginal infection, urinary incontinence, and other medical needs.
 
Molecular imaging agents constitute the core of the QuantRx long-term product development focus while diagnostic and therapeutic products provide near-term revenue opportunities beginning in 2008.
 
These healthcare technologies are in different stages of development ranging from commercialization to proof of concept. The Company plans to bring all products to commercialization with manufacturing control maintained by QuantRx and sales and marketing managed through distributors, OEM, or strategic partners where appropriate. The Company’s goal is to maintain cost and technical leadership through the entire process.
 
Product and Product Candidates
 
QuantRx operates under a two-fold product development strategy: (1) Maximization of the value of internally developed products that are market-ready for near-term distribution, and (2) Aggressive development of technology platforms for products that QuantRx believes will address medical diagnostic and treatment issues into the future.
 
In order to capitalize on short-term revenue opportunities, QuantRx - in introducing its lateral flow diagnostic devices, Miniform PAD product lines and other products - aligns itself with experienced marketing partners that have established distribution channels. QuantRx teams with a manufacturing partner in Asia, as well as niche United States manufacturers, in order to bring products to market more quickly and at lower cost while controlling product quality. 
 
FluoroPharma, Inc., a private company in which QuantRx has a majority ownership interest, is engaged in clinical trials in the development of next-generation imaging agents for PET diagnostics with initial indications for cardiovascular disease. Genomics USA, Inc., another company in which QuantRx has invested, is working toward completion of its HLA - human leukocyte antigen - chip technology for vaccine validity testing and initiation of field tests with the United States Department of Homeland Security.
 
The QuantRx internal development efforts are in parallel with the Company’s investigation of technologies and products for acquisition or licensing to help the Company expand and enhance its current platforms and succeed in its mission to be a market leader in medical diagnostic platforms and products for professionals, industry and consumers.
 
Lateral Flow Diagnostics
 
QuantRx has developed a patented RapidSense technology - a one-step lateral flow test with unique features such as: positive read indication for drugs-of-abuse, improved sensitivity, and the ability to read both large and small molecules. The rapid, disposable, and point-of-care diagnostic technology is ideal for collection of either urine or oral fluids. QuantRx also has a patented technology based on an innovative oral fluid collection device specifically designed for lateral flow tests - the only one-step oral fluid testing device now on the market developed by QuantRx for use with its patented RapidSense technology. This distinctive collection device has applications in the growing market of oral sample collections for issues ranging from drug-abuse testing, gathering biological evidence for criminal investigation, and screening for numerous communicable diseases including HIV/AIDS and other STDs.
 
4

 
The QuantRx device - an industry first - incorporates a removable barrier that prevents test chemicals from washing into the oral cavity during the collection process, and allows the controlled start of the test or tests within the device. Because the QuantRx device is designed for either single or multiple tests using the same sample, it is ideal for emerging drugs-of-abuse analyses and testing for a range of communicable diseases. The patented technology has a feature that provides a more secure "chain of custody" system, helping to ensure the identity and integrity of a specimen from collection through the reporting of test results.
 
In October 2007, the United States Food and Drug Administration (FDA) granted QuantRx 510(k) clearance on its Follicle Stimulating Hormone (FSH) lateral flow immunoassay test for FSH at 10ng/ml. This female fertility test is a one-step lateral flow device that determines ovarian reserve indirectly by measuring FSH in first morning urine. The Company intends to market this test through third party distribution. The Company is currently developing a male fertility test and anticipates introduction of this test in 2008.
 
In the first quarter of 2008, QuantRx filed four 510(k) applications with the FDA for its RapidSense urine based drugs-of-abuse test product line, and it expects to file ten new 510(k) applications for its urine based tests for drugs-of-abuse and menopause over the next 12 months. QuantRx also anticipates the filing of several 510(k) applications for its saliva based drugs-of-abuse test product line by year end. Additionally, feasibility for development of lateral flow tests for infectious disease and cardiac markers is currently being explored.
 
The technology has numerous potential applications. For this reason, QuantRx is pursuing collaborative research and development and original equipment manufacturer (OEM) relationships with companies and organizations interested in exploring new and existing analytes to drive the development of new products for the diagnostic marketplace to advance healthcare worldwide.
 
In the fourth quarter of 2007, QuantRx introduced its QuikSense® (formerly Affirm) drugs-of-abuse product line in the United States and European markets. This OEM product line is intended to develop distribution channels, complement its RapidSense line expected to be introduced in 2008, and enable QuantRx to offer a complete spectrum of drugs-of-abuse test product lines. QuantRx is also developing rapid test POC products in oral care for ALT BioScience, and a female fertility test jointly with a major consumer health company. These two development agreements stipulate certain rights related to manufacturing or royalties upon successful development and commercialization of the products, to be negotiated in good faith and defined in separate agreements upon successful completion of development as defined in the development agreements.
 
Molecular Diagnostic Imaging
 
The Company, through FluoroPharma, is developing proprietary diagnostic imaging products, with initial focus on the development of novel PET imaging agents for efficient detection and assessment of acute and chronic forms of Coronary Artery Disease (CAD). To date, the technology has been applied to the development of three cardiovascular imaging agents - CardioPET, BFPET, and VasoPET. The agents rapidly target either the myocardial cells within the heart or the vulnerable plaque within the coronary arteries and, combined with PET scanning, provide a non-invasive, highly specific, and efficient assessment of heart metabolism and physiology. Future applications exist in the broader cardiovascular, oncology, and neurology arenas.
 
5

 
CardioPET, FluoroPharma’s lead product, is a novel metabolic agent in development for the following intended uses: (a) detection of ischemic and infarcted tissue in patients with suspected or proven forms of acute and chronic CAD, particularly in those patients that cannot undergo stress-testing; and, (b) Cardiac Viability Assessment (CVA), for the prediction of functional improvement prior to, or following, revascularization in patients with acute CAD, including myocardial infarction.
 
CardioPET represents a potentially highly sensitive means of detecting ischemia at rest, because it can detect subtle metabolic insufficiency in myocardium. Thus, a primary application of CardioPET is its use in the assessment of patients with acute and chronic CAD that cannot undergo stress-testing.
 
CardioPET may also be ideal as the metabolic component in CVA due to its ability to specifically identify damaged but viable myocardial tissue. In contrast to non-viable scar tissue, viable myocardial tissue can undergo revascularization, which has been documented to improve left ventricular function and increase survival.
 
CardioPET will address two separate populations: (1) the estimated 1.75 million patients with chronic forms of CAD in the United States that undergo pharmacologic stress-testing due to stress-test contraindication; and, (2) the 350,000 patients with presumptive hibernating or stunned myocardium. For at-rest assessment of the former population, we believe CardioPET may be readily adopted by the cardiology community for the assessment of this patient pool. For CVA testing, we believe that CardioPET’s “first mover” advantage, when combined with the favorable technical parameters relative to currently available glucose-based agents such as fluorodeoxyglucose (FDG), should result in favorable market adoption. Another potential application for CardioPET is as a substitute for regular stress testing, as physicians see the benefit of fewer total scans and potentially faster diagnoses.
 
Following the filing of an Investigational New Drug (IND) application with the FDA, a Phase I clinical trial for CardioPET commenced in 2006 and the Company presented the positive results in the first quarter of 2008. The trial was designed to evaluate safety, distribution and dosimetry of CardioPET as a PET tracer for myocardial imaging in healthy subjects and patients with CAD. All primary study and safety endpoints were achieved; the drug and treatment were exceedingly well-tolerated. The Phase II clinical trial is expected to commence in 2008.
 
BFPET is a blood flow imaging device being developed for use as a myocardial perfusion agent in conjunction with stress-testing for the detection of ischemic and infarcted myocardial tissue in patients with suspected or proven chronic CAD.
 
BFPET has been designed to enter the myocardial cells of the heart muscle in direct proportion to blood flow and membrane potential—the two most important physiological indicators of adequate blood supply to the heart. BFPET effectively differentiates between those cells of the myocardium that are ischemic (reversibly damaged), infarcted (irreversibly damaged), and those that are healthy. Because ischemic and infarcted cells take up significantly less BFPET than normal healthy myocardial cells, the signal emitted by the tracer attached to BFPET is inversely proportional to the extent of myocardial injury, the result of which can be visualized with PET imaging technologies.
 
6

 
Currently, it is estimated that approximately 80% of the 7 million patients with suspected acute and chronic forms of CAD in the United States are evaluated using the combination of blood flow imaging agents (blood flow agents) and stress-testing. An additional 350,000 patients undergo CVA in which a blood flow agent, such as BFPET, is used in combination with a metabolic imaging agent such as FDG or the Company’s CardioPET. We believe that BFPET may represent the first commercially feasible cardiovascular blood flow agent for the PET market.
 
VasoPET is a novel imaging agent for the detection of inflamed and/or coronary artery plaque formation in patients with CAD. VasoPET, if successful and approved, could represent the first cardiovascular PET product to reliably differentiate between vulnerable and stable coronary artery plaque.
 
Coronary artery plaques grow over time and progressively narrow the lumen of the coronary artery until blood flow to the heart diminishes to a critical level. The rupture of atherosclerotic plaque and the subsequent formation of clots overlying the plaque are currently recognized as the primary mechanisms of myocardial and cerebral infarctions. Therefore, the detection of vulnerable plaque in atherosclerotic lesions is a highly desirable goal and to this date remains both a significant clinical objective and large unaddressed market opportunity.
 
VasoPET is positioned to capture a small percentage of the entire atherosclerosis scanning market, which represents more than 50 million Americans. Preliminary estimates for the VasoPET market are a direct function of the more than 100,000 patients that undergo carotid artery procedures annually. There is a significant need to follow up after treatment to track the success of these procedures. We conservatively estimate that VasoPET will gradually become the standard follow up for carotid artery procedures and that 75% of patients will be scanned with VasoPET one year post-surgery.
 
FluoroPharma has completed the studies necessary for the filing of INDs for the myocardial perfusion imaging agent, BFPET, and atherosclerotic plaque imaging agent, VasoPET. Single-dose preclinical toxicology studies revealed no untoward affects of either compound when they were administered in doses up to one million times the anticipated clinical dose. The Company has submitted the IND application for BFPET, and following institutional review board (IRB) approval of the proposed studies, commenced Phase I clinical trials to evaluate safety and dosimetry in healthy subjects in the first quarter of 2008.
 
Each of the Company’s products will require significant clinical validation and a lengthy FDA approval process. While the approval process is not as long for these products as for a true drug, the process will entail several years and a large number of patients. We anticipate that it will be several years before our first New Drug Application (NDA) will be filed with the FDA.
 
SNPchip Genome-based Diagnostic Microarray Chips
 
Forming the basis of our next-generation point-of-care diagnostic technology is the clinically optimized microarray technology of Genomics USA, an affiliate of which QuantRx owns approximately 20% on a fully diluted basis. This technology platform is based on the non-covalent attachment of DNA probes to a surface which allows for cost-effective fabrication and manufacturing. This novel technology produces the only microarrays for analyzing intermediate numbers of genes.
 
The test array resides on a one-square-centimeter silicon chip that contains thousands of DNA probes that identify specific human gene sequences of diagnostic interest. The current competitive technologies require dispensing of a 10-fold excess of DNA, over that required to actually cover the microarray surface. In the QuantRx genomic technology, the adsorptive self assembly is nearly quantitative, requiring no more that a one fold excess of applied material.
 
7

 
The human DNA code has 3 billion letters, with 99.9 percent being identical between any two humans. QuantRx has as its focus population-scale testing for indications such as Human Papilloma Virus (HPV), the primary cause of cervical cancer, and Human Lymphocyte Antigen (HLA) typing, the segment of the genome that controls the body’s immune system determining the body’s reaction to drugs, vaccines, transplanted tissue, and disease.
 
Since the ability of an individual to respond to a particular drug or vaccine is essentially determined by his/her immune response - determined by the HLA type- a key application for this HLA-based technology will be related to vaccine development and personalized vaccine delivery; assuring a vaccine’s effectiveness for a particular individual. Other uses for a defined HLA type will include tissue transplantation, population scale testing for HPV and other viral disease, personalized treatment of microbial infection, and personalized treatment for autoimmune diseases such as arthritis and multiple sclerosis.
 
The biophysical properties of these "self-assembling" DNA microarrays allow SNP-based hybridizations simply and directly, without the need to perform single-base extension or any other secondary biochemical treatment. This simplification reduces the cost of the product, increases signal quality, and allows the product to be used by non-experts, especially in field-testing or small-clinic environments.
 
Follow-on products in the personalized medicine market will service chemical therapeutics, especially those applications in which personal genetic variation at a number of gene sites can cooperate to alter treatment responsiveness for conditions such as obesity, depression, cardiovascular risk, and others.
 
Development of this critical HLA determinate test has been accelerated by the infusion of approximately $3 million via a Defense Advanced Research Projects Agency (DARPA) sponsored Small Business Innovation Research (SBIR) grant, with the focus being to provide the military with information necessary to determine who would benefit from various vaccines in the event of a biowarfare release. A prototype of this test is anticipated in 2008. Initial commercialization of the HLA microarray chip for its application in vaccine development is expected in early 2009.
 
Properly validated, awareness of a patient’s HLA type will be as vital to medical practice as knowledge of one’s blood type, and testing and typing of an infant’s HLA at birth will become common practice.
 
Miniform PADs for Diagnosis and Treatment
 
The miniform PAD is a QuantRx patented technology that provides the basis for a line of products that address an array of consumer health issues including: temporary relief of hemorrhoid and minor vaginal infection itch and discomfort, feminine urinary incontinence, drug delivery, and medical sample collection for diagnostic testing.
 
The QuantRx miniform PAD is biodegradable and flushable, making it safe, convenient, and easy to use; addressing the growing trend in medicine to turn to products that seek to improve health and treat disease chiefly by assisting the body’s innate capacity to recover from illness and injury.
 
8

 
PADKit®
 
The PADKit integrates the miniform technology with QuantRx’s diagnostic expertise. The PADKit contains a miniform used as a collection device to collect a sample for diagnostic evaluation. Vaginally, the miniform collects blood along with numerous cells, vaginal mucous and discharge flushed out by the menstrual flow or during normal daily exfoliation. The PADKit is designed to provide the preferred sample collection system population scale testing for indications such as HPV, Human Immunodeficiency Virus (HIV), and general health screening, where healthcare professionals are not readily accessible.
 
Although significant improvements have been made in the area of Pap test sample reading and sample preparation, clinical indications support broad testing for HPV will have a greater impact in lowering the incidence of cervical cancer. The Company believes the PADKit will provide a superior and more consistent sample, as well as a simpler, more comfortable and convenient procedure for HPV testing. The Company further hopes to demonstrate viability of the PADKit as the basis of various other diagnostic and screening tests.
 
The Company has been issued several patents for the method and apparatus for collecting vaginal fluid and exfoliated vaginal cells for diagnostic purposes, collection of a sample for general diagnostic screening, and the collection of an anal sample for prostate and other diagnostic purposes. Several clinical studies have been conducted on the PADKit, which have provided data needed to show the degree to which the sample collected can be used to replace other accepted samples. QuantRx plans to proceed with further clinical trials and submission to the FDA for marketing approval of the PADKit, together with an appropriate strategic partner, and will continue to pursue additional patent protection.
 
Unique® Miniforms
 
The Company's Unique miniform is a safe, new, convenient, and flushable technology for the underserved Over-the-Counter (OTC) hemorrhoid and feminine urinary incontinence markets. The disposable miniform pads contain no adhesives and require no insertion, and it is small enough to fit in the palm of a hand.
 
The Unique miniform is available as a treated pad for the temporary relief of the itch and discomfort associated with hemorrhoids and minor vaginal infection, and as an untreated pad, for the daily protection of light urinary or anal leakage.
 
QuantRx initiated a limited web-based domestic roll-out of the Unique miniform in late 2007. This effort is intended to support the development of strategic partnership(s) to expand the retail availability of the product across the United States and internationally.
 
QuantRx has significant experience manufacturing its miniform and a clear understanding of its costs. The Company currently has contracted with a firm based in Taiwan to manufacture its pads. The miniform technology is protected by numerous patents covering various applications, the manufacturing process, and certain materials.
 
Distribution Arrangements
 
On July 7, 2006 (the effective date), QuantRx and Synova Healthcare, Inc. (Synova) entered into a distribution agreement pursuant to which Synova would act as the exclusive distributor of specified hemorrhoid products of QuantRx in the United States. The initial term of the agreement was to commence on the effective date and, unless sooner terminated as provided in the agreement, was to continue in effect for a period of five years following the month in which Synova made its first shipment of products to its initial customers. Management estimated the effective term of the agreement to be six years from the effective date.
 
9

 
QuantRx received an up-front, non-refundable payment of $500,000 upon execution of the distribution agreement, which was recorded as deferred revenue and was amortized into revenue over the expected term of the agreement, which was six years. QuantRx recognized revenue of $459,901 and $40,099 in 2007 and 2006, respectively. In December 2007, in accordance with the terms of the distribution agreement, QuantRx delivered notice of termination of the agreement and recognized the remaining deferred revenue at that time of $383,513.
 
Competition
 
Our industry is highly competitive and characterized by rapid and significant technological change. Significant competitive factors in our industry include, among others, product efficacy and safety; the timing and scope of regulatory approvals; the government reimbursement rates for and the average selling price of products; the availability of raw materials and qualified manufacturing capacity; manufacturing costs; intellectual property and patent rights and their protection; and sales, marketing and distribution capabilities.
 
We face, and will continue to face, competition from organizations such as pharmaceutical and biotechnology companies, as well as academic and research institutions. Some of these organizations, including Inverness Medical Innovations, Inc., Biosite, Inc., Quidel Corporation, and Meridian Bioscience, Inc., are pursuing products based on technologies similar to our technologies. These organizations have developed and are currently marketing products, and are pursuing other technological approaches designed to produce products that compete with our product candidates.
 
Any product candidates that we successfully develop, which are approved for sale by the FDA or similar international regulatory authorities in other countries, may compete with competitive products currently being used or that may become available in the future. Many of our competitors have substantially greater capital resources than we have, and greater capabilities and resources for research, conducting preclinical studies and clinical trials, regulatory affairs, manufacturing, marketing and sales. As a result, we may face competitive disadvantages relative to these organizations should they develop or commercialize a competitive product.
 
Raw Materials and Manufacturing
 
The Company has limited manufacturing capacity for research and development projects and contracts the manufacturing of all of its products to third-party manufacturers in and outside the United States. All manufactured products are produced under standard operating procedures developed and controlled by the Company’s quality system, which specifies approved raw materials, vendors, and manufacturing methodology.
 
Intellectual Property Rights and Patents
 
The Company's technology portfolio, with more than three dozen patents, patents pending and licensed patents, includes: (1) RapidSense point-of-care testing products based on QuantRx core intellectual property related to lateral flow techniques for the consumer and healthcare professional markets; (2) through FluoroPharma, molecular imaging agents for positron emission tomography (PET) and fluorescence imaging, with initial application in cardiovascular disease, addressing significant unmet medical needs by providing clinicians with important tools for early discovery and assessment; (3) through our affiliate, Genomics USA, Inc., genome-based diagnostic chips for the laboratory and healthcare professional markets; and (4) PAD technology for diagnosis and treatment of women's health concerns and other medical needs.
 
10

 
Patents and other proprietary rights are an integral part of our business. It is our policy to seek patent protection for our inventions and also to rely upon trade secrets and continuing technological innovations and licensing opportunities to develop and maintain our competitive position.
 
However, the patent positions of companies like ours involve complex legal and factual questions and, therefore, their enforceability cannot be predicted with any certainty. Our issued patents, those licensed to us, and those that may be issued to us in the future may be challenged, invalidated or circumvented, and the rights granted thereunder may not provide us with proprietary protection or competitive advantages against competitors with similar technology. Furthermore, our competitors may independently develop similar technologies or duplicate any technology developed by us. Because of the extensive time required for development, testing and regulatory review of a potential product, it is possible that, before any of our product candidates can be approved for sale and commercialized, our relevant patent rights may expire or remain in force for only a short period following commercialization. Expiration of patents we own or license could adversely affect our ability to protect future product development and, consequently, our operating results and financial position.
 
QuantRx and its subsidiary have 14 patents issued, 11 patents pending, and 12 licensed patents.
 
 
·
12 related to POC Diagnostics technology
     
 
·
10 related to Molecular Imaging technology
     
 
·
15 related to PAD technology
 
QuantRx also holds numerous United States trademarks, including QuantRx, PADkit, RapidSense and Unique.
 
Licensing and Development Agreements
 
The Company has a licensing agreement with Branan Medical Corporation to license its use of the RapidSense technology in connection with the oral screening of drugs-of-abuse.
 
QuantRx entered into a patent license agreement with The Procter & Gamble Company effective July 1, 2006. The agreement licenses patent rights and know-how for certain hemorrhoid treatment pads and related coatings. QuantRx has also entered into two development agreements in 2007 to develop rapid test POC products in oral care for ALT BioScience, and a female fertility test with a major consumer health company. Both agreements stipulate certain rights related to manufacturing or royalty rights upon successful development and commercialization of the developed products, to be negotiated in good faith and defined in separate agreements upon successful completion of development as defined in the development agreements.
 
11

 
Regulatory Requirements
 
Our products and manufacturing activities are subject to regulation by the FDA, and by other federal, state, local and foreign regulatory authorities. Pursuant to the Food, Drug, and Cosmetic Act of 1938, commonly known as the FD&C Act, and the regulations promulgated under it, the FDA regulates the research, development, clinical testing, manufacture, packaging, labeling, storage, distribution, promotion, advertising and sampling of medical devices and medical imaging products. Before a new device or pharmaceutical product can be introduced to the market, the manufacturer must generally obtain marketing clearance through a section 510(k) notification, through a Premarket Approval (PMA), or NDA.
 
In the United States, medical devices intended for human use are classified into three categories, Class I, II or III, on the basis of the controls deemed reasonably necessary by the FDA to assure their safety and effectiveness with Class I requiring the fewest controls and Class III the most controls. Class I, unless exempted, and Class II devices are marketed following FDA clearance of a Section 510(k) premarket notification. Since Class III devices (e.g., a device whose failure could cause significant human harm or death) tend to carry the greatest risks, the manufacturer must demonstrate that such a device is safe and effective for its intended use by submitting a PMA application. PMA approval by the FDA is required before a Class III device can be lawfully marketed in the United States. Usually, the PMA process is significantly more time consuming and costly than the 510(k) process.
 
The U.S. regulatory scheme for the development and commercialization of new pharmaceutical products, which includes are targeted molecular imaging agents, can be divided into three distinct phases: an investigational phase including both preclinical and clinical investigations leading up to the submission of an NDA; a period of FDA review culminating in the approval or refusal to approve the NDA; and the post-marketing period.
 
All of our OTC products derived from the Miniform technology, including Unique, are currently classified as Class I - exempt devices, requiring written notification to the FDA before marketing. The Company’s RapidSense product candidates generally require validation and notification to the FDA under Section 510(k) prior to commercialization. The Company does not currently market any product that requires full clinical validation as a Class III product under FDA regulations.
 
In addition, the FD&C Act requires device manufacturers to obtain a new FDA 510(k) clearance when there is a substantial change or modification in the intended use of a legally marketed device, or a change or modification, including product enhancements, changes to packaging or advertising text and, in some cases, manufacturing changes, to a legally marketed device that could significantly affect its safety or effectiveness. Supplements for approved PMA devices are required for device changes, including some manufacturing changes that affect safety or effectiveness, or disclosure to the consumer, such as labeling. For devices marketed pursuant to 510(k) determinations of substantial equivalence, the manufacturer must obtain FDA clearance of a new 510(k) notification prior to marketing the modified device. For devices marketed with PMA, the manufacturer must obtain FDA approval of a supplement to the PMA prior to marketing the modified device. Such regulatory requirements may require the Company to retain records for up to seven years, and be subject to periodic regulatory review and inspection of all facilities and documents by the FDA.
 
The FD&C Act requires device manufacturers to comply with Good Manufacturing Practices regulations. The regulations require that medical device manufacturers comply with various quality control requirements pertaining to design controls, purchasing contracts, organization and personnel, including device and manufacturing process design, buildings, environmental control, cleaning and sanitation; equipment and calibration of equipment; medical device components; manufacturing specifications and processes; reprocessing of devices; labeling and packaging; in-process and finished device inspection and acceptance; device failure investigations; and record keeping requirements including complaint files and device tracking. Company personnel and non-affiliated contract auditors periodically inspect the contract manufacturers to assure they remain in compliance.
 
12

 
The Company’s Portland, Oregon, facility will comply with FDA and ISO standards as the facility moves toward manufacturing. 
 
Certain of our product candidates will require significant clinical validation prior to obtaining marketing clearance from the FDA. The Company intends to contract with appropriate and experienced CROs (contract research organizations) to prepare for and review the results from clinical field trials. The Company engages certain scientific advisors, consisting of scientific Ph.D.s and M.D.s, who contribute to the scientific and medical validity of its clinical trials when appropriate.
 
Research and Development Activities
 
We spent the following amounts on research and development activities during the years ended December 31, 2007 and 2006:
 
2007: $2,012,419
 
2006: $665,636
 
We expect that our research and development expenses will continue to increase due to the initiation of numerous clinical trials and the continued development of our product lines.
 
Employees
 
As of December 31, 2007, we had 17 full-time employees and 2 part-time employees; 12 of whom were full-time employees of QuantRx and 7 of whom were employees of FluoroPharma, a subsidiary of QuantRx. Our employees are not represented by a labor organization or covered by a collective bargaining agreement.
 
Risk Factors
 
You should consider carefully the following risks, along with other information contained in this Form 10-KSB. The risks and uncertainties described below are not the only ones that may affect us. Additional risks and uncertainties also may adversely affect our business and operations, including those discussed in Item 6 - Management’s Discussion and Analysis of Financial Condition and Results of Operations. If any of the following risks actually occur, our business, results of operations, and financial condition could be adversely affected.
 
We have a history of incurring net losses and we may never become profitable.
 
For the year ended December 31, 2007, the Company had an accumulated deficit of $37,388,222. Our losses resulted principally from costs related to our research programs and the development of our product candidates and general and administrative costs relating to our operations. Since the Company presently has limited sources of revenues and is committed to continuing its research and development activities, we may incur substantial and increasing losses in 2008. We cannot assure you that we will ever become profitable.
 
13

 
We will need to obtain additional funding to support our planned level of operations, and we may not be able to obtain such capital on a timely basis or under commercially reasonable terms, if at all.
 
We expect that our need for additional capital will be substantial and the extent of this need will depend on many factors, some of which are beyond our control, including the successful and continued development of our product candidates; the costs associated with protecting and expanding our patent and other intellectual property rights; future payments, if any, received or made under existing or possible future collaborative arrangements; the timing of regulatory approvals needed to market our product candidates; and market acceptance of our products.
 
It is possible that the Company will not generate positive cash flow from operations for several years. We cannot assure you that funds will be available to us in the future on favorable terms, if at all. If adequate funds are not available to us on terms that we find acceptable, or at all, we may be required to delay, reduce the scope of, or eliminate research and development efforts or clinical trials on any or all of our product candidates. We may also be forced to curtail or restructure our operations, obtain funds by entering into arrangements with collaborators on unattractive terms or relinquish rights to certain technologies or product candidates that we would not otherwise relinquish in order to continue independent operations.
 
Further testing of certain of our product candidates is required and regulatory approval may be delayed or denied, which would limit or prevent us from marketing our product candidates and significantly impair our ability to generate revenues. 
 
     Human pharmaceutical products are subject to rigorous preclinical testing and clinical trials and other approval procedures mandated by the FDA and foreign regulatory authorities. Various federal and foreign statutes and regulations also govern or influence the manufacturing, safety, labeling, storage, record keeping and marketing of pharmaceutical products. The process of obtaining these approvals and the subsequent compliance with appropriate U.S. and foreign statutes and regulations is time-consuming and requires the expenditure of substantial resources. In addition, these requirements and processes vary widely from country to country.
 
     To varying degrees based on the regulatory plan for each product candidate, the effect of government regulation and the need for FDA and other regulatory agency approval will delay commercialization of our product candidates, impose costly procedures upon our activities, and put us at a disadvantage relative to larger companies with which we compete. There can be no assurance that FDA or other regulatory approval for any products developed by us will be granted on a timely basis, or at all. If we discontinue the development of one of our product candidates, our business and stock price may suffer.
 
The Company may face intense competition.
 
The Company is engaged in a segment of the biomedical industry that is highly competitive. If successfully brought into the marketplace, any of the Company’s products will likely compete with several existing products. The Company anticipates that it will face intense and increasing competition in the future as new products enter the market and advanced technologies become available. We cannot assure that existing products or new products developed by competitors will not be more effective, or more effectively marketed and sold than those by the Company. Competitive products may render the Company’s products obsolete or noncompetitive prior to the Company’s recovery of development and commercialization expenses.
 
14

 
Many of the Company’s competitors will also have significantly greater financial, technical and human resources and will likely be better equipped to develop, manufacture and market products. Smaller companies may also prove to be significant competitors, particularly through collaborative arrangements with large biotechnology companies. Furthermore, academic institutions, government agencies and other public and private research organizations are becoming increasingly aware of the commercial value of their inventions and are actively seeking to commercialize the technology they have developed. Accordingly, competitors may succeed in commercializing products more rapidly or effectively than the Company, which would have a material adverse effect on the Company.
 
There is no assurance that the Company’s products will have market acceptance.
 
The success of the Company will depend in substantial part on the extent to which our products achieve market acceptance. We cannot predict or guarantee that physicians, patients, healthcare insurers or maintenance organizations, or the medical community in general, will accept or utilize any products of the Company.
 
If we fail to establish marketing and sales capabilities or fail to enter into effective sales, marketing and distribution arrangements with third parties, we may not be able to successfully commercialize our products.
 
We are primarily dependent on third parties for the sales, marketing and distribution of our products. We may enter into various agreements providing for the commercialization of our product candidates. We intend to sell our product candidates primarily through third parties and establish relationships with other companies to commercialize them in other countries around the world. We currently have limited internal sales and marketing capabilities, or an infrastructure to support such activities. Therefore, our future profitability will depend in part on our ability to enter into effective marketing agreements. To the extent that we enter into sales, marketing and distribution arrangements with other companies to sell our products in the United States or abroad, our product revenues will depend on their efforts, which may not be successful.
 
The Company’s success will be dependent on licenses and proprietary rights it receives from other parties, and on any patents it may obtain.
 
Our success will depend in large part on the ability of the Company and its licensors to (i) maintain license and patent protection with respect to our products, (ii) defend patents and licenses once obtained, (iii) maintain trade secrets, (iv) operate without infringing upon the patents and proprietary rights of others, and (iv) obtain appropriate licenses to patents or proprietary rights held by third parties if infringement would otherwise occur, both in the United States and in foreign countries. 
 
The patent positions of biomedical companies, including those of the Company, are uncertain and involve complex legal and factual questions. There is no guarantee that the Company or its licensors have or will develop or obtain the rights to products or processes that are patentable, that patents will issue from any of the pending applications or that claims allowed will be sufficient to protect the technology licensed to the Company. In addition, we cannot be certain that any patents issued to or licensed by the Company will not be challenged, invalidated, infringed or circumvented, or that the rights granted thereunder will provide competitive disadvantages to the Company.
 
Litigation, which could result in substantial cost, may also be necessary to enforce any patents to which the Company has rights, or to determine the scope, validity and unenforceability of other parties’ proprietary rights, which may affect the rights of the Company. United States patents carry a presumption of validity and generally can be invalidated only through clear and convincing evidence. There can be no assurance that the Company’s patents would be held valid by a court or administrative body or that an alleged infringer would be found to be infringing. The mere uncertainty resulting from the institution and continuation of any technology-related litigation or interference proceeding could have a material adverse effect on the Company pending resolution of the disputed matters.
 
15

 
The Company may also rely on unpatented trade secrets and know-how to maintain its competitive position, which it seeks to protect, in part, by confidentiality agreements with employees, consultants and others. There can be no assurance that these agreements will not be breached or terminated, that the Company will have adequate remedies for any breach, or that trade secrets will not otherwise become known or be independently discovered by competitors.
 
Protecting our proprietary rights is difficult and costly.
 
The patent positions of pharmaceutical and biotechnology companies can be highly uncertain and involve complex legal and factual questions. Accordingly, we cannot predict the breadth of claims allowed in these companies’ patents or whether the Company may infringe or be infringing these claims. Patent disputes are common and could preclude the commercialization of our products. Patent litigation is costly in its own right and could subject us to significant liabilities to third parties. In addition, an adverse decision could force us to either obtain third-party licenses at a material cost or cease using the technology or product in dispute.
 
We may be unable to retain skilled personnel and maintain key relationships.
 
The success of our business depends, in large part, on our ability to attract and retain highly qualified management, scientific and other personnel, and on our ability to develop and maintain important relationships with leading research institutions and consultants and advisors. Competition for these types of personnel and relationships is intense from numerous pharmaceutical and biotechnology companies, universities and other research institutions. There can be no assurance that the Company will be able to attract and retain such individuals on commercially acceptable terms or at all, and the failure to do so would have a material adverse effect on the Company.
 
The Company has limited manufacturing capabilities and may not be able to efficiently develop manufacturing capabilities or contract for such services from third parties on commercially acceptable terms.
 
The Company has limited manufacturing capacity. The Company has established relationships with third-party manufacturers for the commercial production of our products. There can be no assurance that the Company will be able to maintain relationships with third-party manufacturers on commercially acceptable terms or that third-party manufacturers will be able to manufacture our products on a cost-effective basis in commercial quantities under good manufacturing practices mandated by the FDA.
 
The dependence upon third parties for the manufacture of products may adversely affect future costs and the ability to develop and commercialize our products on a timely and competitive basis. Further, there can be no assurance that manufacturing or quality control problems will not arise in connection with the manufacture of our products or that third party manufacturers will be able to maintain the necessary governmental licenses and approvals to continue manufacturing such products. Any failure to establish relationships with third parties for its manufacturing requirements on commercially acceptable terms would have a material adverse effect on the Company.
 
16

 
In the future, we anticipate that we will need to obtain additional or increased product liability insurance coverage and it is uncertain that such increased or additional insurance coverage can be obtained on commercially reasonable terms.
 
The business of the Company will expose it to potential product liability risks that are inherent in the testing, manufacturing and marketing of pharmaceutical products. There can be no assurance that product liability claims will not be asserted against the Company. The Company has obtained insurance coverage; however, there can be no assurance that the Company will be able to obtain additional product liability insurance on commercially acceptable terms or that the Company will be able to maintain such insurance at a reasonable cost or in sufficient amounts to protect against potential losses. A successful product liability claim or series of claims brought against the Company could have a material adverse effect on the Company.
 
Insurance coverage is increasingly more difficult to obtain or maintain.
 
Obtaining insurance for our business, property and products is increasingly more costly and narrower in scope, and we may be required to assume more risk in the future. If we are subject to third-party claims or suffer a loss or damage in excess of our insurance coverage, we may be required to share that risk in excess of our insurance limits. Furthermore, any first- or third-party claims made on any of our insurance policies may impact our ability to obtain or maintain insurance coverage at reasonable costs or at all in the future.
 
The market price of our shares, like that of many biotechnology companies, is highly volatile.
 
Market prices for the Company’s common stock and the securities of other medical and biomedical technology companies have been highly volatile and may continue to be highly volatile in the future. Factors such as announcements of technological innovations or new products by the Company or its competitors, government regulatory action, litigation, patent or proprietary rights developments, and market conditions for medical and high technology stocks in general can have a significant impact on any future market for common stock of the Company.
 
Trading of our common stock is limited, which may make it difficult for you to sell your shares at times and prices that you feel are appropriate.
 
Trading of our common stock, which is conducted on the OTC Bulletin Board, has been limited. This adversely affects the liquidity of our common stock, not only in terms of the number of shares that can be bought and sold at a given price, but also through delays in the timing of transactions and reduction in security analysts and the media’s coverage of us. This may result in lower prices for our common stock than might otherwise be obtained and could also result in a larger spread between the bid and ask prices for our common stock.
 
The issuance of shares of our preferred stock may adversely affect our common stock.
 
The board of directors of the Company is authorized to designate one or more series of preferred stock and to fix the rights, preferences, privileges and restrictions thereof, without any action by the stockholders. The designation and issuance of such shares of our preferred stock may adversely affect the common stock, if the rights, preferences and privileges of such preferred stock (i) restrict the declaration or payment of dividends on common stock, (ii) dilute the voting power of common stock, (iii) impair the liquidation rights of the common stock, or (iv) delay or prevent a change in control of the Company from occurring, among other possibilities.
 
17

 
Because we do not expect to pay dividends, you will not realize any income from an investment in our common stock unless and until you sell your shares at a profit.
 
We have never paid dividends on our common stock and do not anticipate paying any dividends for the foreseeable future. You should not rely on an investment in our stock if you require dividend income. Further, you will only realize income on an investment in our shares in the event you sell or otherwise dispose of your shares at a price higher than the price you paid for your shares. Such a gain would result only from an increase in the market price of our common stock, which is uncertain and unpredictable.
 
Item 2. Description of Property
 
Our corporate headquarters are located at 100 South Main Street, Suite 300, Doylestown, Pennsylvania, in 3,034 square feet of space occupied under a five year lease that expires on July 31, 2011. This lease contains a termination option after the third year for a fee of $5,000. We also lease 6,310 square feet of commercial space used primarily for research and development at 5920 NE 112th Street, Portland, Oregon. This lease expires on September 30, 2011.
 
We expect that our current facilities will be sufficient for the foreseeable future. To the extent that we require additional space in the near future, we believe that we will be able to secure additional leased facilities at commercially reasonable rates.
 
Item 3. Legal Proceedings
 
As of the date hereof, the Company is not a party to or engaged in any material legal proceeding.
 
Item 4. Submission of Matters to a Vote of Security Holders
 
No matter was submitted to a vote of security holders during the fourth quarter of 2007.
 
PART II
 
 
Our Common Stock
 
Our common stock began trading on the OTC Bulletin Board under the symbol “QTXB” in June 2006. Previously our common stock traded on the OTC Pink Sheets. The prices below are based on high and low reported sales prices as reported by the OTC Bulletin Board and Pink Sheets during the calendar quarters indicated. The prices represent quotations between dealers without adjustment for retail mark-up, mark-down or commission and do not necessarily represent actual transactions.
 
18

 
   
High
 
Low
 
Year ended December 31, 2007
         
Fourth Quarter
 
$
0.89
 
$
0.43
 
Third Quarter
 
$
1.20
 
$
0.80
 
Second Quarter
 
$
1.39
 
$
0.91
 
First Quarter
 
$
1.60
 
$
1.16
 
               
Year ended December 31, 2006
           
Fourth Quarter
 
$
1.69
 
$
0.95
 
Third Quarter
 
$
1.60
 
$
0.95
 
Second Quarter
 
$
1.70
 
$
0.80
 
First Quarter
 
$
1.90
 
$
1.40
 
 
Stockholders
 
As of March 24, 2008 there were approximately 386 holders of record of our common stock, one of which was Cede & Co., a nominee for the Depository Trust Company or DTC. Shares of common stock that are held by financial institutions, as nominees for beneficial owners, are deposited into principal accounts at the DTC, and are considered to be held of record by Cede & Co. as one stockholder. 
 
Dividends
 
We have not declared nor paid any cash dividends on our common stock. We currently anticipate that we will retain all of our future earnings for use in the expansion and operation of our business, thus we do not anticipate paying any cash dividends on our common stock in the foreseeable future.
 
Equity Compensation Plan Information
 
The following table provides information as of December 31, 2007 regarding equity compensation plans approved by the Company’s security holders. The Company does not have any equity compensation plans that have not been approved by our security holders.
 
Plan category
 
Number of securities to be issued upon exercise of outstanding options, warrants and rights
 
Weighted-average exercise price of outstanding options, warrants and rights
 
Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in the second column)
 
1997 Equity compensation plans approved by security holders
   
1,372,500
 
$
0.74
   
-
 
2007 Equity compensation plans approved by security holders
   
419,250
 
$
0.85
   
7,580,750
 
 
19

 
Purchases of Equity Securities
 
During the year ended December 31, 2007, we did not purchase any outstanding shares of our equity securities, nor did any person or entity purchase any outstanding equity securities of the Company on our behalf.
 
Recent Sales of Unregistered Securities
 
In the fourth quarter of 2007, the Company issued an aggregate of 6,000 common stock warrants with five-year terms and exercise prices equal to the market price on the dates of grant ($0.61 and $0.75). These warrants were in consideration of business development consulting services. The fair value of these warrants was calculated to be $3,500, which was expensed in 2007.
 
In the fourth quarter of 2007, 6,250 non-qualified common stock options were granted to a member of the board of directors and issued from the Company’s 2007 Incentive and Non-Qualified Stock Option Plan. The options were issued with an exercise price of $0.69, have a term of five years and vested immediately.
 
In the fourth quarter of 2007, a total of 413,000 qualified common stock options were granted to employees and issued from the Company’s 2007 Incentive and Non-Qualified Stock Option Plan. The options were issued with an exercise price of $0.85, and have a term of ten years. The options vest monthly over one year.
 
There were no additional sales of unregistered securities other than as reported in prior reports on Forms 10-KSB, 10-QSB or 8-K.
 
The issuances of the above securities were deemed to be exempt from registration under the Securities Act of 1933, as amended (the “Securities Act”), in reliance on Section 4(2) of the Securities Act or Regulation D promulgated under the Securities Act, as transactions by an issuer not involving a public offering.
 
Item 6. Management’s Discussion and Analysis
 
QuantRx Biomedical Corporation was incorporated on December 5, 1986 in the State of Nevada. The Company’s principal business office is located at 100 South Main Street, Suite 300, Doylestown, Pennsylvania. QuantRx also has a research and development facility in Portland, Oregon.
 
QuantRx is a broad-based diagnostics company focused on the development and commercialization of innovative diagnostic products based on its patented technology platforms for the worldwide healthcare industry. The Company’s strategy is to commercialize its products through partners or distributors, contracting the manufacturing to third-party partners while maintaining control over the manufacturing process.
 
The Company's platforms include: (1) POC testing products based on QuantRx core intellectual property related to lateral flow techniques; (2) through FluoroPharma, molecular imaging agents for positron emission tomography (PET); (3) through our affiliate, Genomics USA, Inc., genome-based diagnostic chips; and (4) PAD miniform technology.
 
In April 2007, QuantRx increased its ownership in FluoroPharma, Inc., a development-stage molecular imaging company, to 57.78% of outstanding capital stock, resulting in its consolidation effective April 1, 2007. The investment in FluoroPharma is intended to strategically expand QuantRx’s diagnostic platforms.
 
20

 
The following discussion of our financial condition should be read together with our financial statements and related notes included in this annual report on Form 10-KSB.
 
Our Consolidated Results of Operations
 
We recognized revenues of $747,119 and $91,463 for the years ended December 31, 2007 and 2006, respectively. Total costs and operating expenses for the years ended December 31, 2007 and 2006 were $6,735,285 and $3,102,796, respectively. Highlights of the major components of our results of operations are detailed and discussed below:
 
 
 
 
Year Ended
December 31, 2007
 
 
Year Ended
December 31, 2006
 
Revenues
 
$
747,119
 
$
91,463
 
General and Administrative
 
$
2,377,866
 
$
1,295,744
 
Professional Fees
 
$
1,881,179
 
$
818,174
 
Research and Development
 
$
2,012,419
 
$
665,636
 
Other Expense, net
 
$
474,227
 
$
4,681,181
 
 
Revenues of $51,364 for the years 2007 and 2006 were derived from a licensing agreement for a specific use of our RapidSense technology in drug-of-abuse diagnostics. Additionally, in 2006, QuantRx received an up-front, non-refundable payment of $500,000 upon execution of a distribution agreement, which has been recorded as deferred revenue and was being amortized into revenue over the expected term of the agreement, which was six years. However, in the fourth quarter of 2007, the contract was terminated in accordance with the terms of the distribution agreement, and QuantRx recognized the remaining deferred revenue at that time. QuantRx recognized $459,901 and $40,099 from this distribution agreement in 2007 and 2006. QuantRx also recognized $235,146 in 2007 related to development agreements.
 
General and administrative expenses include, but are not limited to, payroll and related expenses, rent, office and insurance expenses. The increase of $1,082,122 in general and administrative expenses from 2006 to 2007 is primarily due to increased personnel expenses of $413,604 and the consolidation of FluoroPharma’s financial results effective April 1, 2007, resulting in the inclusion of $374,272 of FluoroPharma’s general and administrative expenses, mainly reflecting personnel expenses.
 
Professional fees include the costs of legal, consulting and auditing services provided to us. The increase of $1,063,005 in professional fees from 2006 to 2007 is primarily attributable to the consolidation of FluoroPharma, resulting in the inclusion of $422,457 of professional fees, composed primarily of legal fees of $174,859 and stock-based compensation for management consultants of $182,203. The remaining increase in professional fees was primarily related to $381,436 in increased expenses associated with financial consultants, $181,823 in increased expenses related to investor and public relations consultants, and the addition of a FDA regulatory consultant at a cost of $107,514, offset by a decrease in legal fees of $54,714 associated with patent related issues, regulatory compliance and acquisitions. While we are unable to estimate future costs of this nature with any degree of certainty, we intend to retain a limited number of skilled management to reduce the need for extensive assistance from consultants and accounting professionals.
 
Research and development expense primarily reflects technical consulting and expenses incurred in connection with the development of our product candidates. The increase of $1,346,783 from 2006 to 2007 in research and development expenses is primarily due to increased personnel expenses of $196,584 and product development costs of $132,799, as well as the consolidation of FluoroPharma, resulting in the inclusion of research and development expenses of $958,023, primarily consisting of $515,792 for personnel and consulting, and $345,463 related to clinical trials.
 
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Net loss for 2007 was $6,044,337, a decrease of $1,648,177 from the $7,692,514 net loss reported for 2006. The decrease in net loss was primarily attributable to the satisfaction and conversion of convertible promissory notes issued in 2005 and 2006 and their related non-cash accrued interest and non-cash amortization of debt discounts and deferred financing costs of $4,724,335, offset by increased expenses as described above of $3,632,489, of which $1,788,633 relate to the consolidation of FluoroPharma.
 
Liquidity and Capital Resources
 
We believe that our short-term and long-term liquidity can be affected by many factors, some of which are beyond our control, including the successful and continued development of our product candidates; the costs associated with protecting and expanding our patent and other intellectual property rights; future payments, if any, received or made under existing or possible future collaborative arrangements; the timing of regulatory approvals needed to market our product candidates; and market acceptance of our products.
 
We believe that the ability to develop and commercialize our diagnostic products and other technologies will depend in significant part on our ability to:
 
 
·
enter into effective sales, marketing and distribution arrangements with other parties;
     
 
·
operate without infringing upon the proprietary rights of others;
     
 
·
obtain patents;
     
 
·
develop and obtain additional patents and technologies in our key operating areas of interest; and
     
 
·
establish relationships with third-party manufacturers.
 
At December 31, 2007, the Company had cash and cash equivalents of $213,332 as compared to $1,256,912 at December 31, 2006.
 
During the year ended December 31, 2007, we used $4,985,904 of cash for operating activities, as compared to $1,817,560 during the year ended December 31, 2006. The increase in the use of cash for operating activities was a result of increased expenses, primarily related to professional fees, personnel, the development of our product candidates, and the consolidation of financial results for our subsidiary FluoroPharma effective April 1, 2007.
 
Cash used in investing activities during the year ended December 31, 2007 was $987,280 compared to $2,814,014 during the year ended December 31, 2006. Cash expenditures related to investments in FluoroPharma prior to consolidation were $521,777 during 2007 and $2,245,023 during 2006. Additionally, investments of $200,000 during 2007 and $400,000 during 2006 were made in two development stage companies to strategically expand our diagnostic platforms by adding new product candidates to our pipeline.
 
Cash provided by financing activities relating to the issuance of shares of common stock during the year ended December 31, 2007 was $3,374,996 as compared to $1,917,633 during the year ended December 31, 2006. Cash provided through the exercise of warrants during 2007 was $567,777 as compared to $57,430 during 2006. Cash provided through the issuance of convertible promissory notes was $1,000,000 during 2007 and $2,931,400 during 2006.
 
22

 
In the future, QuantRx expects to expand operations, including increasing ownership in its affiliates, with the use of additional financing and increased revenues from operations with the introduction of several products in 2008 and potential licensing opportunities. In the first quarter of 2008, QuantRx issued 10% senior secured convertible promissory notes and warrants to purchase 250,000 shares of common stock for aggregate gross proceeds of $1,000,000. Cash debt financing costs of $70,000 were incurred and are due to the placement agent. Proceeds of the financing will be used for general corporate purposes.
 
The following table summarizes our material contractual obligations relating to operating lease obligations at December 31, 2007 and the effect such obligations are expected to have on our liquidity and cash flows in future periods. At December 31, 2007, there were no material capital expenditure commitments.
 
   
 Payments due by Period
 
   
Total
 
Less than 1 year
 
Years
2 - 3
 
Years
4 - 5
 
More than 5 Years
 
Operating lease obligations
 
$
324,941
 
$
122,263
 
$
158,803
 
$
43,875
 
$
-
 
 
Off-Balance Sheet Arrangements
 
We have not entered into any transactions with unconsolidated entities in which we have financial guarantees, subordinated retained interests, derivative instruments or other contingent arrangements that expose us to material continuing risks, contingent liabilities or any other obligations under a variable interest in an unconsolidated entity that provides us with financing, liquidity, market risk or credit risk support.
 
Critical Accounting Policies
 
Revenue Recognition
 
The Company recognizes revenue in accordance with SEC Staff Accounting Bulletin Topic 13 when persuasive evidence of an arrangement exists and delivery has occurred, provided the fee is fixed or determinable and collection is probable. The Company assesses whether the fee is fixed and determinable based on the payment terms associated with the transaction. If a fee is based upon a variable such as acceptance by the customer, the Company accounts for the fee as not being fixed and determinable. In these cases, the Company defers revenue and recognizes it when it becomes due and payable. Up-front engagement fees are recorded as deferred revenue and amortized to income on a straight-line basis over the term of the agreement, although the fee is due and payable at the time the agreement is signed or upon annual renewal. Payments related to substantive, performance-based milestones in an agreement are recognized as revenue upon the achievement of the milestones as specified in the underlying agreement when they represent the culmination of the earnings process. The Company assesses the probability of collection based on a number of factors, including past transaction history with the customer and the current financial condition of the customer. If the Company determines that collection of a fee is not reasonably assured, revenue is deferred until the time collection becomes reasonably assured. Significant management judgment and estimates must be made and used in connection with the revenue recognized in any accounting period. Material differences may result in the amount and timing of our revenue for any period if our management made different judgments or utilized different estimates.
 
23

 
The Company recognizes revenue from nonrefundable minimum royalty agreements from distributors or resellers upon delivery of product to the distributor or reseller, provided no significant obligations remain outstanding, the fee is fixed and determinable, and collection is probable. Once minimum royalties have been received, additional royalties are recognized as revenue when earned based on the distributor’s contractual reporting obligations. QuantRx is able to recognize minimum royalty payments on an accrual basis, as they are specified in the contract. However, since the Company cannot forecast product sales by licensees, royalty payments that are based on product sales by the licensees are not determinable until the licensee has completed their computation of the royalties due and/or remitted their cash payment to us. Should information on licensee product sales become available so as to enable QuantRx to recognize royalty revenue on an accrual basis, materially different revenues and results of operations could occur.
 
Our strategy includes entering into collaborative agreements with strategic partners for the development, commercialization and distribution of our product candidates. Such collaboration agreements may have multiple deliverables. We evaluate multiple deliverable arrangements pursuant to Emerging Issues Task Force (EITF) 00-21, “Revenue Arrangements with Multiple Deliverables.” Pursuant to EITF 00-21, in arrangements with multiple deliverables where we have continuing performance obligations, contract, milestone and license fees are recognized as revenue together with any up-front payments over the term of the arrangement as performance obligations are completed, unless the deliverable has stand-alone value and there is objective, reliable evidence of fair value of the undelivered element in the arrangement. In the case of an arrangement where it is determined there is a single unit of accounting, all cash flows from the arrangement are considered in the determination of all revenue to be recognized. Cash received in advance of revenue recognition is recorded as deferred revenue.
 
Use of Estimates
 
The preparation of financial statements and related disclosures in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, revenues and expenses and related disclosures of contingent assets and liabilities in the financial statements and accompanying notes. The accounting policies discussed below are considered by management to be the most important to the Company’s financial condition and results of operations, and require management to make its most difficult and subjective judgments due to the inherent uncertainty associated with these matters. All significant estimates and assumptions are developed based on the best information available to us at the time made and are regularly reviewed and adjusted when necessary. We believe that our estimates and assumptions are reasonable under the circumstances; however, actual results may vary from these estimates and assumptions. Additional information on significant accounting principles is provided in Note 2 of the attached financial statements.
 
Impairment of Assets
 
We assess the impairment of long-lived assets, including our other intangible assets, whenever events or changes in circumstances indicate that their carrying value may not be recoverable in accordance with Statement of Financial Accounting Standards (SFAS) No. 144, “Accounting for the Impairment or Disposal of Long-Lived Assets.” The determination of related estimated useful lives and whether or not these assets are impaired involves significant judgments, related primarily to the future profitability and/or future value of the assets. Changes in our strategic plan and/or market conditions could significantly impact these judgments and could require adjustments to recorded asset balances. We hold investments in companies having operations or technologies in areas which are within or adjacent to our strategic focus when acquired, all of which are privately held and whose values are difficult to determine. We record an investment impairment charge if we believe an investment has experienced a decline in value that is other than temporary. Future changes in our strategic direction, adverse changes in market conditions or poor operating results of underlying investments could result in losses or an inability to recover the carrying value of the investments that may not be reflected in an investment’s current carrying value, thereby possibly requiring an impairment charge in the future.
 
24

 
We performed annual impairment tests of our equity method goodwill in accordance with SFAS No. 142, “Goodwill and Other Intangible Assets.” Under SFAS No. 142, equity method goodwill is not amortized but is subject to impairment tests in accordance with Accounting Principles Board Opinion No. 18, “The Equity Method of Accounting for Investments in Common Stock,” under which QuantRx would have recognized an impairment loss had there been a loss in the value of the equity method goodwill which was deemed to be other than a temporary decline.
 
In determining fair value of assets, QuantRx bases estimates on historical experience and on various other assumptions that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about carrying values of assets that are not readily apparent from other sources. Actual fair value may differ from management estimates resulting in potential impairments causing material changes to certain assets and results of operations.
 
Share-based Payments
 
We grant options to purchase our common stock to our employees and directors under our stock option plan subject to the provisions of SFAS No. 123(R), “Share-Based Payments.” Effective January 1, 2005, we use the fair value method to apply the provisions of SFAS No. 123(R) with a modified prospective application which provides for certain changes to the method for valuing share-based compensation. The valuation provisions of SFAS No. 123(R) apply to new awards and to awards that are outstanding on the effective date and subsequently modified or cancelled. Under the modified prospective application, prior periods are not revised for comparative purposes.
 
Upon adoption of SFAS No. 123(R), we began estimating the value of stock option awards on the date of grant using a Black-Scholes pricing model (Black-Scholes model). The determination of the fair value of share-based payment awards on the date of grant using the Black-Scholes model is affected by our stock price as well as assumptions regarding a number of complex and subjective variables. These variables include, but are not limited to, our expected stock price volatility over the term of the awards, actual and projected employee stock option exercise behaviors, and risk-free interest rate. If factors change and we employ different assumptions in the application of SFAS No. 123(R) in future periods, the compensation expense that we record under SFAS No. 123(R) may differ significantly from what we have recorded in the current period.
 
Estimates of share-based compensation expenses are significant to our financial statements, but these expenses are based on option valuation models and will never result in the payment of cash by us.
 
Deferred Taxes
 
We recognize deferred tax assets and liabilities based on differences between the financial statement carrying amounts and tax bases of assets and liabilities, which requires management to perform estimates of future transactions and their respective valuations. We review our deferred tax assets for recoverability and establish a valuation allowance if it is more likely than not that the Company will not realize the benefit of the net deferred tax asset. At December 31, 2007 and 2006, a valuation allowance has been established. The likelihood of a material change in the valuation allowance depends on our ability to generate sufficient future taxable income. In the future, if management determines that the likelihood exists to utilize the Company’s deferred tax assets, a reduction of the valuation allowance could materially increase the Company’s net deferred tax asset.
 
25

 
Item 7. Financial Statements
 
Audited consolidated balance sheets for the years ended December 31, 2007 and 2006 and audited consolidated statements of operations, changes in stockholders’ equity and cash flows for the years ended December 31, 2007 and 2006 are included immediately following the signature page to this report, beginning on page F-1.
 
Item 8. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
 
None.
 
Item 8A. Controls and Procedures
 
Disclosure Controls and Procedures
 
As required by Rules 13a-15 and 15d-15 of the Securities Exchange Act of 1934, the Company has evaluated, with the participation of management, including the Chief Executive Officer and the Chief Financial Officer, the effectiveness of its disclosure controls and procedures (as defined in such rules) as of the end of the period covered by this report. Based on such evaluation, the Chief Executive Officer and Chief Financial Officer concluded that the Company’s disclosure controls and procedures are effective to ensure that information required to be disclosed by the Company in reports prepared in accordance with the rules and regulations of the Securities and Exchange Commission (SEC) is recorded, processed, summarized and reported within the time periods specified by the SEC’s rules and forms.
 
Our management, including the Company’s Chief Executive Officer and Chief Financial Officer, does not expect that the Company’s disclosure controls and procedures will prevent all errors and all fraud. A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within the Company have been detected. These inherent limitations include the realities that judgments in decision-making can be faulty, and that breakdowns can occur because of simple error or mistake.
 
Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people, or by management override of the control. The design of any system of controls also is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions; over time, controls may become inadequate because of changes in conditions, or the degree of compliance with the policies or procedures may deteriorate. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.
 
26

 
Changes in Internal Control over Financial Reporting
 
There have been no changes in the Company’s internal control over financial reporting that occurred during the fourth quarter of the year ended December 31, 2007 that have materially affected, or are reasonably likely to materially affect, the Company’s internal control over financial reporting. The Company continues to review its disclosure controls and procedures, including its internal controls over financial reporting, and may from time to time make changes aimed at enhancing their effectiveness and to ensure that the Company’s systems evolve with its business.
 
Management’s Report on Internal Control over Financial Reporting
 
Our management is responsible for establishing and maintaining adequate internal control over financial reporting. Our internal control system is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles in the United States (GAAP) and includes those policies and procedures that:
 
 
·
pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the company;
     
 
·
provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with GAAP, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and
     
 
·
provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the Company’s assets that could have a material effect on its financial statements.
 
Because of its inherent limitations, a system of internal control over financial reporting can provide only reasonable assurance and may not prevent or detect misstatements. Further, because of changes in conditions, effectiveness of internal controls over financial reporting may vary over time. Our system contains self-monitoring mechanisms, and actions are taken to correct deficiencies as they are identified.
 
 Our management conducted an evaluation of the effectiveness of the system of internal control over financial reporting based on the framework in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission. Based on this evaluation, our management concluded that our system of internal control over financial reporting was effective as of December 31, 2007.
 
 This report does not include an attestation report of our registered public accounting firm regarding internal control over financial reporting. Management’s report was not subject to attestation by our registered public accounting firm pursuant to temporary rules of the Securities and Exchange Commission that permit us to provide only management’s report in this annual report.
 
Item 8B. Other Information
 
None.
 
27

 
PART III
 
Item 9. Directors, Executive Officers, Promoters, Control Persons and Corporate Governance; Compliance with Section 16(a) of the Exchange Act 
 
 
The following table sets forth the Company’s executive officers and directors as of December 31, 2007:
 
Directors & Executive Officers
 
Age
 
Position
Walter W. Witoshkin(1)
 
63
 
Chairman & CEO
William H. Fleming, Ph.D.(2)
 
61
 
Director, Secretary & Chief Scientific Officer
Sasha Afanassiev
 
40
 
CFO, Treasurer & VP of Finance
Cindy Horton
 
43
 
VP of Diagnostics
Dr. Shalom Hirschman(2)
 
71
 
Director
Dr. Arthur Hull Hayes, Jr.(1)
 
74
 
Director
 
(1)
Mr. Witoshkin and Dr. Hayes have been elected/ratified to hold office until the 2008 annual meeting of stockholders, or until their successor is duly elected or appointed, unless their office is earlier vacated.
 
(2)
Drs. Fleming and Hirschman have been elected to hold office until the 2009 annual meeting of stockholders, or until their successor is duly elected or appointed, unless their office is earlier vacated.
 
Walter W. Witoshkin is Chairman and Chief Executive Officer of QuantRx Biomedical Corporation. A 40-year veteran of the pharmaceutical, healthcare and biomedical industries, Mr. Witoshkin began serving as a Director and Chief Executive Officer in May, 2005. He has held senior executive positions at leading healthcare product and pharmaceutical companies, most recently SmithKline Beecham, now Glaxo SmithKline, where he was a Vice President of Business Development and Chief Financial Officer. In 1989, Mr. Witoshkin established Menley & James Laboratories, Inc., after purchasing 32 SmithKline Beecham over-the-counter pharmaceutical and toiletry product brands. Menley & James had its initial public offering in 1992. He earlier held several senior finance positions at American Cyanamid, which became American Home and then Wyeth. Mr. Witoshkin joined QuantRx from Trident Group LLC, global operational consultants to the pharmaceutical and related healthcare industries. As a founding partner of Trident Group, Mr. Witoshkin specialized in alternative sourcing for manufacturing and the acquisition of technologies and products.
 
Mr. Witoshkin also serves as a director of Echo Therapeutics, Inc. and a number of privately held companies, including QuantRx subsidiary FluoroPharma.
 
William H. Fleming, Ph.D., has served as Chief Scientific Officer of QuantRx since July 2005, as a Director and Secretary of QuantRx since February 1994, as Vice President-Diagnostics of QuantRx from August 1997 through July 2005, and as Acting CEO from 2003 until May 2005. From February 1994 through August 1997, Dr. Fleming served as President and Chief Operating Officer of QuantRx. In addition, he was President, Chief Operating Officer and a Director of ProFem from July 1993 until its merger with QuantRx in June 1994. From April 1992 until July 1993, Dr. Fleming served as an associate with Sovereign Ventures, a healthcare consulting firm; concurrently he served as director of corporate development of Antivirals, Inc., a biotechnology company involved in antisense technology. Dr. Fleming is a director of ERC, a non-profit organization.
 
Sasha Afanassiev has served as Chief Financial Officer and Vice President-Finance of QuantRx Biomedical Corporation since September 2005, and has also served as Treasurer of the Company since December 2005. Prior to joining QuantRx, Mr. Afanassiev worked in public accounting from 1989 through 2001, where he serviced a widely diversified client base. In 2001 Mr. Afanassiev established a managerial accounting and tax consulting firm as principal and founder. Mr. Afanassiev holds a bachelor’s degree from Temple University’s School of Business and Management and is a licensed Certified Public Accountant in the Commonwealth of Pennsylvania.
 
28

 
Cindy Horton has served as Vice President-Diagnostics of QuantRx since July 2005. Ms. Horton was the national sales manager for Applied Biotech, Inc., an Inverness Medical Innovations Company. Prior to that, she directed sales for Drugs of Abuse POC’s, Professional POC’s for Women Health and branded OTC products for private label customers at ABI, and its predecessor Forefront Diagnostics.
 
Independent Directors
 
Shalom Hirschman has served as a Director of QuantRx since September 2005. Dr. Hirschman was Professor of Medicine, Director of the Division of Infectious Diseases and Vice-Chairman of the Department of Medicine at Mt. Sinai School of Medicine and the Mount Sinai Hospital. He spent nearly three decades at Mt. Sinai until his retirement. He then became the CEO, President and Chief Scientific Officer of Advanced Viral Research Corp. from which he retired in 2004.
 
Arthur Hull Hayes, Jr. has served as a Director of QuantRx since September 2006. Dr. Hayes served as Commissioner of the United States Food and Drug Administration from 1981 to 1983. Dr. Hayes founded and was President and Chief Operating Officer of MediScience Associates, Inc., a consulting organization that works with pharmaceutical firms, biomedical companies and foreign governments, from July 1991 to January 2006, and Clinical Professor of Medicine and Pharmacology at the Pennsylvania State University College of Medicine from 1981 to 2004. From 1986 to 1990, Dr. Hayes was President and Chief Executive Officer of E.M. Pharmaceuticals, a North American subsidiary of Germany’s E. Merck AG.
 
Compliance with Section 16(a) of the Exchange Act
 
Section 16(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), requires the Company’s Directors and Officers, and persons who own more than 10% of a registered class of the Company’s equity securities (“Section 16 Persons”), to file with the SEC initial reports of ownership and reports of changes in ownership of common stock and other equity securities of the Company. Section 16 Persons are required by SEC regulation to furnish the Company with copies of all Section 16(a) reports they file. Based on the Company’s review of the forms it has received, on other reports filed by Section 16 Persons with the SEC and on the Company’s records, the Company believes that during 2007, (1) Cindy Horton did not timely file a Form 4 to report the grant of 50,000 common stock options, (2) William Fleming did not timely file a Form 4 to report the grant of 50,000 common stock options, (3) Sasha Afanassiev did not timely file a Form 4 to report the grant of 50,000 common stock options, (4) Walter Witoshkin did not timely file a Form 4 to report the grant of 250,000 common stock options, (5) Arthur H. Hayes, Jr. did not timely file a Form 4 to report the grant of 6,250 common stock options, and (6) Matthew Balk did not timely file a Form 4, as a more than 10% owner, to report the receipt of 105,300 common stock warrants pursuant to an advisory services agreement between QuantRx and Burnham Hill Partners, of which the Reporting Person is a Managing Member.
 
Family Relationships
 
There are no family relationships among our directors, executive officers or persons nominated or chosen to become directors or executive officers of ours.
 
29

 
Involvement in Certain Legal Proceedings
 
QuantRx is not aware of any events that have occurred during the past five years that are required to be disclosed pursuant to Item 401(d) of Regulation S-B.
 
Code of Ethics
 
QuantRx has adopted a code of ethics, which applies to all our directors, officers and employees. Our code of ethics is intended to comply with the requirements of Item 406 of Regulation S-B. A copy of the Company’s code of ethics may also be obtained by any person without charge by sending a written request addressed to: QuantRx Biomedical Corporation, 100 South Main Street, Suite 300, Doylestown, Pennsylvania 18901.
 
Audit Committee
 
As of the date hereof, Shalom Hirschman and William Fleming serve on the audit committee of the Company’s board of directors. William Fleming is the chairperson of the audit committee. Our board of directors has not yet designated an independent financial expert, as defined by the SEC, as it is still recruiting qualified candidates to fill the position. During the last fiscal year the audit committee held no separate meetings. Until such time as a financial expert is appointed, all members of our board of directors perform the responsibilities of the audit committee, providing oversight of our accounting functions and controls.
 
Compensation Committee
 
As of the date hereof, Arthur H. Hayes, Jr. and William Fleming serve on the compensation committee of the Company’s board of directors. Arthur H. Hayes, Jr. is the chairperson of the compensation committee. The compensation committee reviews and recommends to the Board the compensation and benefits of our executive officers, administers our stock option plans, and establishes general policies relating to compensation and employee benefits. During the last fiscal year the compensation committee held no meetings.
 
30

 
Item 10. Executive Compensation
 
Summary Compensation
 
The following Summary Compensation Table sets forth summary information as to compensation received by the Company’s Chief Executive Officer and the two other most highly compensated executive officers of the Company as of December 31, 2007.

Name And
Principal Position
 
Year
 
Salary
($)
 
Bonus
($)
 
Stock
Awards
($)
 
Option
Awards
($)
 
Non-Equity Incentive Plan Compensation
($)
 
Nonqualified Deferred Compensation Earnings
($)
 
All other Compensation
($)
 
Total
($)
 
Walter W.
   
2007
   
240,000
   
75,000
   
-
   
153,712
(1)
 
-
   
-
   
-
   
468,712
 
Witoshkin, CEO
   
2006
   
240,000
   
10,000
   
-
   
66,454
   
-
   
-
   
-
   
316,454
 
Cindy Horton, VP of
   
2007
   
150,000
   
-
   
-
   
42,175
   
-
   
-
   
-
   
192,175
 
Diagnostics
   
2006
   
150,000
   
6,250
   
-
   
23,850
   
-
   
-
   
-
   
180,100
 
Sasha Afanassiev,
   
2007
   
150,000
   
-
   
-
   
10,375
   
-
   
-
   
-
   
160,375
 
CFO, Treasurer & VP of Finance
   
2006
   
110,167
   
6,250
   
-
   
125,325
   
-
   
-
   
-
   
241,742
 
 
(1) Includes $35,383 related to the issuance of options from a subsidiary for his directorship.
 
The amounts in the Option Awards column reflect the dollar amount recognized and expensed for financial statement reporting purposes for the years ended December 31, 2007 and 2006, in accordance with SFAS 123(R) of awards of stock options and thus do not represent aggregate fair value of grants. The Company used the Black-Scholes option price calculation to value the options granted in 2007 and 2006 using the following assumptions: risk-free rate of 5.77% and 4.93%; volatility of 1.35 and 1.70; actual term and exercise price of options granted.
 
Employment Contracts
 
We have entered into an employment contract with our Chief Executive Officer that provides for the continuation of salary if terminated for reasons other than cause, as defined in those agreements. At December 31, 2007, the future employment contract commitment for such key executive based on stated termination clause was approximately $240,000. All other employees are “at-will” employees and may be terminated at any time by the Company.
 
31

 
Outstanding Equity Awards at Fiscal Year-End

   
Option Awards
 
Name
 
Number of Securities Underlying Unexercised Options
(#)
Exercisable
 
Number of Securities Underlying Unexercised Options
(#)
Unexercisable
 
Equity Incentive Plan Awards: Number of Securities Underlying Unexercised Unearned Options
(#)
 
Option Exercise Price
($)
 
Option Expiration Date
 
Walter W. Witoshkin,
CEO & President (1)
   
925,872
62,500
   
-
-
   
74,128
187,500
   
0.50
0.85
   
05/03/2015
10/08/2017
 
Cindy Horton,
VP of Diagnostics (2)
   
-
12,500
   
-
-
   
100,000
37,500
   
1.60
0.85
   
04/03/2016
10/08/2017
 
Sasha Afanassiev,
CFO, Treasurer &
VP of Finance (3)
   
25,000
75,000
12,500
   
-
-
-
   
-
-
37,500
   
1.60
1.15
0.85
   
04/03/2016
07/25/2016
10/08/2017
 
 
(1)
Options granted 05/03/2005, which expire 05/03/2015 vest as follows; 333,000 shares vested on May 3, 2005 and the remaining options will continue to vest with respect to 18,527 shares each monthly anniversary thereafter until fully-vested. Exercise price exceeded the closing stock price on the date of grant. Options granted 10/08/2007 which expire 10/08/2017 vest monthly over one year. Exercise price is equal to the closing stock price on the date of grant.
 
(2)
Options granted 04/03/2006 vest upon meeting certain sales milestones which have not yet been met. Term of the options is ten years. Options granted 10/08/2007 which expire 10/08/2017 vest monthly over one year. Exercise prices are equal to the closing stock price on the date of grant.
 
(3)
Options granted 04/03/2006 which expire 04/03/2016 vested immediately. Options granted 07/25/2006 which expire 07/25/2016 vested January 1, 2007. Options granted 10/08/2007 which expire 10/08/2017 vest monthly over one year. Exercise prices are equal to the closing stock price on date of grant.
 
There are no outstanding stock awards as of December 31, 2007.
 
The Company used the Black-Scholes option price calculation to value the options granted in 2007 and 2006 using the following assumptions: risk-free rate of 5.77% and 4.93%; volatility of 1.35 and 1.70; actual term and exercise price of options granted. See Note 14 to the Consolidated Financial Statements for more details on option issuances.
 
32

 
Director Compensation
 
QuantRx compensates independent members of the Board of Directors cash compensation of $5,000 and 6,250 stock options per Board meeting attended in person; up to a maximum of four meetings per year. All options are granted at year end and have a term of five years and an exercise price equal to the closing stock price on date of grant.
 
The following table summarizes Director Compensation for the year ended December 31, 2007.
 
 
Name
 
Fees Earned or Paid in Cash ($)
 
Stock Awards
($)
 
Option Awards
($)
 
Non-Equity Incentive Plan Compensation
($)
 
Nonqualified Deferred Compensation Earnings
($)
 
All Other Compensation ($)
 
Total
($)
 
Walter W. Witoshkin
   
-
   
-
   
-
   
-
   
-
   
-
   
-
 
William H. Fleming, Ph.D.
   
-
   
-
   
-
   
-
   
-
   
-
   
-
 
Dr. Shalom Hirschman (1)
   
-
   
-
   
-
   
-
   
-
   
-
   
-
 
Dr. Arthur Hull Hayes, Jr. (2)
 
$
5,000
   
-
 
$
3,813
   
-
   
-
 
-
 
$
8,813
 
Evan Levine (3)
   
-
   
-
   
-
   
-
   
-
   
-
   
-
 
 
(1)
Dr. Shalom Hirschman did not receive compensation related to his directorship pursuant to the terms of a consulting agreement in effect during 2007. He received a monthly fee of $4,000 in accordance with the terms of the agreement. Additional details can be found in Note 15 to the Consolidated Financial Statements.
 
(2)
Dr. Arthur H. Hayes, Jr. received an option grant at December 31, 2007 for 6,250 common shares. Material terms are as follows: December 31, 2007 grant date, exercise price of $0.69 and a five year term.
 
(3)
Mr. Levine’s term as director ended as of the 2007 annual meeting of shareholders.
 
The Company used the Black-Scholes option price calculation to value the options granted in 2007 using the following assumptions: risk-free rate of 5.77%; volatility of 1.35; actual term and exercise price of options granted.
 
Item 11. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
 
The following table sets forth certain information as of March 17, 2008, concerning the ownership of common stock by (i) each stockholder of the Company known by the Company to be the beneficial owner of more than 5% of the outstanding shares of common stock, (ii) each current member of the Board of Directors of the Company, and (iii) each Executive Officer of the Company named in the Summary Compensation Table appearing under “Executive Compensation” above.
 
The number and percentage of shares beneficially owned is determined in accordance with Rule 13d-3 of the Securities Exchange Act and the information is not necessarily indicative of beneficial ownership for any other purpose. Under that rule, beneficial ownership includes any shares as to which the individual or entity has voting power or investment power and any shares that the individual has the right to acquire within 60 days through the exercise of any stock option or other right. Unless otherwise indicated in the footnotes or table, each person or entity has sole voting and investment power, or shares such powers with his or her spouse, with respect to the shares shown as beneficially owned.
 
33

 
The Company had only common stock outstanding at March 17, 2008; therefore the following table refers to our common stock.
 
Name and Address of Beneficial Owner (1)
 
Amount and Nature of Beneficial Ownership as of March 17, 2008
 
Percentage
of Class (2)
 
Walter W. Witoshkin (3)
   
1,166,665
   
2.72
%
William H. Fleming(4)
   
525,369
   
1.26
%
Shalom Hirschman (5)
   
506,250
   
1.21
%
Sasha Afanassiev (6)
   
133,335
   
0.32
%
Arthur Hull Hayes, Jr. (7)
   
12,500
   
0.03
%
Evan Levine (8)
6725 Mesa Ridge Road, Suite 100
San Diego, CA 92121
   
3,790,220
   
9.48
%
Matthew Balk (9)
570 Lexington Avenue
New York, NY 10021
   
5,728,009
   
13.74
%
Mark Capital, LLC (10)
6725 Mesa Ridge Road, Suite 100
San Diego, CA 92121
   
2,945,000
   
7.03
%
Sherbrooke Partners, LLC
570 Lexington Avenue
New York, NY 10021
   
4,508,009
   
10.81
%
Cindy Horton (11)
   
33,335
   
0.08
%
 
(1)
Unless indicated otherwise, the address of each person listed in the table is: c/o QuantRx Biomedical Corporation, 100 South Main Street, Suite 300, Doylestown, Pennsylvania 18901.
   
(2) 
The percentage of beneficial ownership of common stock is based on 41,699,681 shares of common stock outstanding as of March 17, 2008 and excludes all shares of common stock issuable upon the exercise of outstanding options or warrants to purchase common stock or conversion of any common stock equivalents, other than the shares of common stock issuable upon the exercise of options or warrants to purchase common stock held by the named person to the extent such options or warrants are exercisable within 60 days of March 17, 2008.
   
(3)
Ownership is based upon 1,166,665 common stock options, including those exercisable within 60 days of March 17, 2008.
   
(4)
Ownership includes beneficial ownership of 1,000 shares of common stock held by the executive’s father and 33,335 common stock options, including those exercisable within 60 days of March 17, 2008.
   
(5)
Ownership includes 6,250 common stock options currently exercisable.
   
(6)
Ownership is based on 133,335 common stock options, including those exercisable within 60 days of March 17, 2008.
   
(7)
Ownership is based on 12,500 common stock options currently exercisable.
   
(8) 
Includes 2,765,000 shares of common stock and common stock warrants currently exercisable for 180,000 common shares held by Mark Capital, LLC of which Evan Levine is the managing member; 990,000 shares of common stock held by Mr. Levine as custodian for his two children; and 35,220 shares of common stock held by Mr. Levine’s retirement plan.
   
(9)
Includes 4,508,009 shares of common stock held by Sherbrooke Partners, LLC, of which Matthew Balk is the sole member; and 1,220,000 shares of common stock held by Mr. Balk as custodian for his two children.
   
(10)
Ownership includes 180,000 common stock warrants currently exercisable for 180,000 common shares.
   
(11)
Ownership is based on 33,335 common stock options, including those exercisable within 60 days of March 17, 2008.
 
Item 12. Certain Relationships and Related Transactions
 
In the first quarter of 2008, in connection with a debt financing, QuantRx issued warrants with a five-year term to purchase an aggregate of 100,000 shares of common stock at $1.10 per share to Burnham Hill Partners, of which Matthew Balk, a beneficial owner of more than 5% of outstanding shares of common stock, is a managing member. Burnham Hill Partners was the placement agent for the debt financing. Additionally, cash commissions of $70,000 are due to Burnham Hill Partners for its role as placement agent in the transaction.
 
34

 
In October 2007, in connection with a debt financing, QuantRx issued warrants with a five-year term valued at $65,000 to purchase an aggregate of 100,000 shares of common stock at $1.10 per share to Burnham Hill Partners, of which Matthew Balk, a beneficial owner of more than 5% of outstanding shares of common stock, is a managing member. Burnham Hill Partners was the placement agent for the debt financing. Additionally, cash commissions of $70,000 are due to Burnham Hill Partners for its role as placement agent in the transaction.
 
On March 9, 2007 the Company issued 200,000 common stock warrants with a five year term to purchase 200,000 shares of common stock at an exercise price of $1.50. The warrants were issued as payment for financial advisory services to Burnham Hill Partners, of which Matthew Balk, a beneficial owner of more than 5% of outstanding shares of common stock, is a managing member. The fair value for these warrants is estimated to be $250,000. Additionally, cash compensation of $200,000 was paid pursuant to the terms of the agreement.
 
Item 13. Exhibits
 
The following exhibits are filed as part of this annual report:
 
Exhibit No.
 
Description
3.1
 
Amended and Restated Articles of Incorporation of the Company (incorporated by reference to Exhibit 3.1 filed with Form 10-KSB filed on April 16, 2001)
     
3.2
 
Certificate of Amendment to the Articles of Incorporation of the Company, dated November 30, 2005 (incorporated by reference to Exhibit 3.2 filed with Form 10-KSB on March 31, 2006)
     
3.3
 
Bylaws of the Company (incorporated by reference to Exhibit 3.2 filed with Form 10KSB40/A filed on September 23, 1999)
     
3.4
 
Certificate of Amendment to the Bylaws of the Company dated December 2, 2005 (incorporated by reference to Exhibit 3.4 filed with Form 10-KSB on March 31, 2006)
     
4.1
 
Form of 8% Convertible Promissory among the Company and investors (incorporated by reference to Exhibit 4.1 filed with Form 10-KSB on March 31, 2006)
     
4.2
 
Form of Warrant to Purchase Shares of Common Stock among the Company and investors (incorporated by reference to Exhibit 4.2 filed with Form 10-KSB on March 31, 2006) 
     
4.3
 
Form of Warrant to Purchase Common Stock among the Company and investors (incorporated by reference to Exhibit 4.3 filed with Form 10-KSB on March 31, 2006)
     
4.4
 
Warrant to Purchase Common Stock, dated November 8, 2005, between the Company and Burnham Hill Partners (incorporated by reference to Exhibit 4.4 filed with Form 10-KSB on March 31, 2006)
     
4.5
 
Form of Senior Convertible Promissory Note, dated October __, 2007, from QuantRx Biomedical Corporation in favor of Investor (incorporated by reference to Exhibit 4.1 filed with Form 8-K on October 24, 2007)
     
4.6
 
Form of Warrant to Purchase Shares of Common Stock of QuantRx Biomedical Corporation, dated October __, 2007 (incorporated by reference to Exhibit 10.2 filed with Form 8-K on October 24, 2007)
     
10.1
 
Letter Agreement, dated December 3, 2005, between the Company and Univest Capital Limited (incorporated by reference to Exhibit 10.1 filed with Form 10-KSB on March 31, 2006)
     
10.2
 
Letter Agreement, dated November 8, 2005, between the Company and Burnham Hill Partners (incorporated by reference to Exhibit 10.2 filed with Form 10-KSB on March 31, 2006)
     
10.3
 
Letter Agreement, dated November 1, 2005, between the Company and Dawson James Securities, Inc. (incorporated by reference to Exhibit 10.3 filed with Form 10-KSB on March 31, 2006)
 
35

 
10.4
 
Letter Agreement, dated April 13, 2005, between the Company and Dawson James Securities, Inc. (incorporated by reference to Exhibit 10.4 filed with Form 10-KSB on March 31, 2006)
     
10.5
 
Distribution Agreement, dated as of July 7, 2006, between Synova, Inc. and the Company (incorporated by reference to Exhibit 10.1 filed with Form 10-QSB on November 14, 2006)
     
10.6
 
Common Stock and Warrant Purchase Agreement, dated as of December 6, 2006, among the Company and the purchasers specified therein (incorporated by reference to Exhibit 10.1 filed with Form 8-K on December 12, 2006)
     
10.7
 
Form of Warrant to Purchase Common Stock among the Company and investors (incorporated by reference to Exhibit 10.2 filed with Form 8-K on December 12, 2006)
     
10.8
 
Registration Rights Agreement, dated as of December 6, 2006, among the Company and the purchasers specified therein (incorporated by reference to Exhibit 10.3 filed with Form 8-K on December 12, 2006)
     
10.9
 
Investment Agreement, dated as of February 17, 2006, between QuantRx Biomedical Corporation and FluoroPharma, Inc.("Investment Agreement”) (incorporated by reference to Exhibit 10.1 filed with Form 10-QSB/A on December 1, 2006)
     
10.10
 
Amendment No. 1, dated as of February 28, 2006, to Investment Agreement (incorporated by reference to Exhibit 10.2 filed with Form 10-QSB/A on December 1, 2006)
     
10.11
 
Amendment No. 2, dated as of March 10, 2006, to Investment Agreement (incorporated by reference to Exhibit 10.3 filed with Form 10-QSB/A on December 1, 2006)
     
10.12
 
Option Agreement, dated as of February 17, 2006, between QuantRx Biomedical Corporation and FluoroPharma, Inc. ("Option Agreement") (incorporated by reference to Exhibit 10.4 filed with Form 10-QSB/A on December 1, 2006)
     
10.13
 
Amendment No. 1, dated as of February 28, 2006, to Option Agreement (incorporated by reference to Exhibit 10.5 filed with Form 10-QSB/A on December 1, 2006)
     
10.14
 
Amended and Restated Investors Rights Agreement, dated as of February 17, 2006, by and among QuantRx Biomedical Corporation, FluoroPharma, Inc. and the stockholders of FluoroPharma, Inc. (incorporated by reference to Exhibit 10.6 filed with Form 10-QSB/A on December 1, 2006)
     
10.15
 
Letter Agreement, dated October 20, 2006, between the Company and Legend Merchant Group, Inc. (incorporated by reference to exhibit 10.15 filed with Form 10-K on April 2, 2007)
     
10.16
 
Stage 2 Investment Agreement, dated as of April 5, 2007, between QuantRx Biomedical Corporation and FluoroPharma, Inc. (incorporated by reference to Exhibit 10.1 filed with Form 8-K on April 19, 2007)
     
10.17
 
2007 Incentive and Non-Qualified Stock Option Plan (incorporated by reference to Exhibit C filed with Schedule 14A on June 5, 2007)
     
10.18
 
Form of Letter Loan Agreement, dated October __, 2007, between Investor and QuantRx Biomedical Corporation (incorporated by reference to Exhibit 10.1 filed with Form 8-K on October 24, 2007)
     
14.1
 
Ethical Guidelines adopted by the Board of Directors of the Company on May 31, 2005 (incorporated by reference to Exhibit 14.1 filed with Form 10-KSB on March 31, 2006)
     
21.1
 
List of subsidiaries of the Company as of December 31, 2007
     
31.1
 
Certification of Principal Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
     
31.2
 
Certification of Principal Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
     
32.1*
 
Certification of Principal Executive Officer pursuant to 18 USC Section 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
 
36

 
32.2*
 
Certification of Principal Financial Officer pursuant to 18 USC Section 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
 
* The certifications attached as Exhibits 32.1 and 32.2 accompany this Annual Report on Form 10-KSB pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 and shall not be deemed "filed" by QuantRx Biomedical Corporation for purposes of Section 18 of the Exchange Act.
 
Item 14. Principal Accounting Fees and Services
 
Audit Fees
 
The aggregate fees billed for professional services rendered by Williams & Webster, P.S. for the audit of our annual financial statements and the reviews of financial statements included in our Forms 10-QSB for years 2007 and 2006 are set forth in the table below.
 
 
 
 
2007
 
 
2006
 
Williams & Webster, P.S.
 
$
43,183
 
$
44,749
 
 
Audit-Related Fees
 
During the years ended December 31, 2007 and 2006, no assurance or related services were performed by Williams & Webster P.S. that were reasonably related to the performance of the audit or review of our financial statements.
 
Tax Fees
 
During the years ended December 31, 2007 and 2006, $4,515 and $6,000 in fees were billed by Williams & Webster, P.S. for tax compliance, tax advice or tax planning services.
 
All Other Fees
 
During the years ended December 31, 2007 and 2006, no fees were billed by Williams & Webster, P.S. other than the fees set forth under the captions “Audit Fees” and “Tax Fees” above.
 
Pre-Approval Policies and Procedures of the Audit Committee
 
The Audit Committee has the sole authority to appoint, terminate and replace our independent auditor. The Audit Committee may not delegate these responsibilities. The Audit Committee has the sole authority to approve the scope, fees and terms of all audit engagements, as well as all permissible non-audit engagements of our independent auditor. 100% of the services provided by Williams & Webster, P.S. were pre-approved by the Audit Committee.
 
37

 
SIGNATURES
 
 Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
 
 
QuantRx Biomedical Corporation
 
 
Date: March 31, 2008
By:  /s/ Walter W. Witoshkin

Walter W. Witoshkin,
Chairman & CEO
   
 
 
Date: March 31, 2008
By:  /s/ Sasha Afanassiev

Sasha Afanassiev,
CFO, Treasurer & VP of Finance
 
Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.
 
 
 
QuantRx Biomedical Corporation
     
     
Date:
March 31, 2008
By:  /s/ Walter W. Witoshkin

Walter W. Witoshkin,
Director
 
 
 
     
Date:
March 31, 2008
By:  /s/ William H. Fleming

William H. Fleming,
Director 
 
 
     
Date:
March 31, 2008
By:  /s/ Shalom Hirschman

Shalom Hirschman,
Director

38

 
STATEMENT OF INFORMATION FURNISHED
 
The following financial statements have been prepared in accordance with Form 10-KSB instructions and in the opinion of management contain all adjustments (consisting of only normal and recurring accruals) necessary to present fairly the consolidated financial position as of December 31, 2007 and 2006, the consolidated results of operations for the years ended December 31, 2007 and 2006, consolidated cash flows for the years ended December 31, 2007 and 2006, and Consolidated Statements of Stockholders’ Equity for the years ended December 31, 2007 and 2006. These results have been determined on the basis of generally accepted accounting principles and practices applied consistently.
 
39

 
 
FINANCIAL STATEMENTS
 
Table of Contents
 
Report of Independent Registered Public Accounting Firm
   
F-2
 
         
Consolidated Balance Sheets as of December 31, 2007 and 2006
   
F-3
 
         
Consolidated Statements of Operations for the Years Ended December 31, 2007 and 2006
   
F-4
 
         
Consolidated Statements of Cash Flows for the Years Ended December 31, 2007 and 2006
   
F-5
 
         
Consolidated Statements of Stockholders’ Equity for the Years Ended December 31, 2007 and 2006
   
F-7
 
         
Notes to Consolidated Financial Statements
   
F-8
 

F-1


QuantRx Biomedical Corporation
Doylestown, Pennsylvania

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We have audited the accompanying consolidated balance sheets of QuantRx Biomedical Corporation as of December 31, 2007 and 2006, and the related consolidated statements of operations, stockholders’ equity and cash flows for the years then ended. These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. Our audit included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of QuantRx Biomedical Corporation as of December 31, 2007 and 2006 and the consolidated results of its operations, stockholders equity and its cash flows for the years then ended in conformity with accounting principles generally accepted in the United States of America.
 

Williams & Webster, P.S.
Certified Public Accountants
Spokane, Washington
March 28, 2008

F-2


QUANTRX BIOMEDICAL CORPORATION
CONSOLIDATED BALANCE SHEETS

   
 December 31,
2007
 
 December 31,
2006
 
ASSETS
           
             
Current Assets:
           
Cash and cash equivalents
 
$
213,332
 
$
1,256,912
 
Accounts receivable
   
80,758
   
-
 
Interest receivable, net of allowance for bad debt of $14,000 and $0
   
-
   
9,917
 
Interest receivable - related party
   
15,650
   
986
 
Inventories
   
37,313
   
-
 
Prepaid expenses
   
227,022
   
113,386
 
Note receivable, net of allowance for bad debt of $200,000 and $0
   
-
   
200,000
 
Note receivable - related party
   
200,000
   
250,000
 
Deferred finance costs, net
   
107,507
   
-
 
Deposits
   
4,448
   
5,350
 
Total Current Assets
   
886,030
   
1,836,551
 
               
Investments
   
200,000
   
2,195,023
 
Property and equipment, net
   
391,720
   
156,823
 
Intangible assets, net
   
2,162,225
   
113,669
 
Security deposits
   
10,667
   
10,667
 
               
Total Assets
 
$
3,650,642
 
$
4,312,733
 
               
LIABILITIES AND STOCKHOLDERS’ EQUITY
             
               
Current Liabilities:
             
Accounts payable
 
$
720,408
 
$
244,863
 
Accrued expenses
   
233,283
   
41,692
 
Deferred revenue, current portion
   
-
   
83,333
 
Short-term convertible notes payable, net of discount
   
795,476
   
-
 
Security deposits
   
2,000
   
-
 
Loans payable, current portion
   
10,882
   
-
 
 Total Current Liabilities
   
1,762,049
   
369,888
 
               
Deferred revenue, long-term portion
   
-
   
376,569
 
Loans payable, long-term portion
   
5,733
   
-
 
Notes payable, long-term portion
   
44,000
   
-
 
               
 Total Liabilities
   
1,811,782
   
746,457
 
               
Commitments and Contingencies
   
-
   
-
 
Minority Interest
   
-
   
-
 
               
Stockholders’ Equity:
             
Convertible preferred stock; $0.01 par value, 25,000,000 authorized
             
Series A shares 9,750,000 designated; no shares issued and
             
outstanding
   
-
   
-
 
Common stock; $0.01 par value, 75,000,000 authorized;
             
41,699,681 and 37,378,080 shares issued and outstanding
   
416,996
   
373,780
 
Additional paid-in capital
   
38,810,086
   
33,706,733
 
Accumulated deficit
   
(37,388,222
)
 
(30,514,237
)
Total Stockholders’ Equity
   
1,838,860
   
3,566,276
 
               
Total Liabilities and Stockholders’ Equity
 
$
3,650,642
 
$
4,312,733
 
 
The accompanying notes are an integral part of these financial statements.
 
F-3


QUANTRX BIOMEDICAL CORPORATION
CONSOLIDATED STATEMENTS OF OPERATIONS 
 
   
For the Years Ended
December 31,
 
   
2007
 
 2006
 
            
Revenues
 
$
747,119
 
$
91,463
 
               
Costs and Operating Expenses:
             
Cost of goods sold (excluding depreciation and amortization)
   
4,056
   
-
 
Sales and marketing
   
244,958
   
302,171
 
General and administrative
   
2,377,866
   
1,295,744
 
Professional fees
   
1,881,179
   
818,174
 
Research and development
   
2,012,419
   
665,636
 
Amortization
   
132,875
   
7,560
 
Depreciation
   
81,932
   
13,511
 
Total Costs and Operating Expenses
   
6,735,285
   
3,102,796
 
               
Loss from Operations
   
(5,988,166
)
 
(3,011,333
)
               
Other Income (Expense):
             
Interest and dividend income
   
76,571
   
44,221
 
Interest expense
   
(23,401
)
 
(287,926
)
Bad debt expense
   
(214,000
)
 
-
 
Rental income
   
20,008
   
-
 
Grant income
   
14,000
   
-
 
Loss on equity investee
   
(267,608
)
 
-
 
Amortization of debt discount to interest expense
   
(52,304
)
 
(4,003,093
)
Amortization of deferred financing costs to interest expense
   
(27,493
)
 
(434,383
)
Total Other Income (Expense), net
   
(474,227
)
 
(4,681,181
)
               
Loss before Minority Interest and Taxes
   
(6,462,393
)
 
(7,692,514
)
               
Minority Interest
   
418,056
   
-
 
Provision for Income Taxes
   
-
   
-
 
               
Net Loss
 
$
(6,044,337
)
$
(7,692,514
)
               
Basic and Diluted Net Loss per Common Share
 
$
(0.15
)
$
(0.26
)
               
Basic and Diluted Weighted Average Shares Used in per Share Calculation
   
40,627,309
   
29,629,947
 
 
The accompanying notes are an integral part of these financial statements.
 
F-4


QUANTRX BIOMEDICAL CORPORATION
CONSOLIDATED STATEMENTS OF CASH FLOWS
 
   
For the Years Ended
December 31,
 
   
2007
 
2006
 
CASH FLOWS FROM OPERATING ACTIVITIES:
          
Net loss
 
$
(6,044,337
)
$
(7,692,514
)
Adjustments to reconcile net loss to net cash used by operating activities:
             
Depreciation and amortization
   
214,807
   
21,071
 
Interest expense related to amortization of non-cash discount, non-cash beneficial conversion feature and deferred financing costs
   
79,797
   
4,437,476
 
Bad debt expense
   
214,000
   
-
 
Issuance of common stock for accrued interest
   
-
   
289,098
 
Stock-based compensation for employee awards
   
235,378
   
253,355
 
Expenses related to common stock warrants issued
   
150,902
   
-
 
Non-cash fair value of warrants and options issued for consulting
   
638,459
   
219,000
 
Non-cash fair value of common stock issued for consulting
   
-
   
19,500
 
Non-cash fair value of warrants issued for purchased R&D
   
-
   
100,010
 
Loss on equity investee
   
267,608
   
-
 
Minority interest
   
(418,056
)
 
-
 
(Increase) decrease in:
             
 Accounts receivable
   
(80,758
)
 
-
 
 Interest receivable
   
(18,747
)
 
(10,903
)
 Inventories
   
(37,313
)
 
-
 
 Prepaid expenses
   
(36,156
)
 
18,359
 
 Deposits
   
23,402
   
(13,655
)
Increase (decrease) in:
             
 Accounts payable
   
145,920
   
127,709
 
 Accrued expenses
   
137,092
   
(45,968
)
 Security deposits
   
2,000
   
-
 
 Deferred revenue
   
(459,902
)
 
459,902
 
               
Net Cash Used by Operating Activities
   
(4,985,904
)
 
(1,817,560
)
               
CASH FLOWS FROM INVESTING ACTIVITIES:
             
Cash paid for purchases of fixed assets
   
(218,853
)
 
(110,491
)
Cash paid for investments
   
-
   
(200,000
)
Cash paid for equity interest in FluoroPharma
   
(1,536,000
)
 
(1,995,023
)
Cash obtained from equity interest in FluoroPharma
   
764,223
   
-
 
Payment on note receivable from FluoroPharma
   
250,000
   
-
 
Increase in note receivable
   
-
   
(200,000
)
Increase in note receivable - related party
   
(200,000
)
 
(250,000
)
Cash paid for licensing agreement
   
(15,000
)
 
(50,000
)
Cash paid for capitalized website development costs
   
(31,650
)
 
(8,500
)
               
Net Cash Used by Investing Activities
   
(987,280
)
 
(2,814,014
)
               
 
F-5

 
CASH FLOWS FROM FINANCING ACTIVITIES:
             
Proceeds from sale of common stock and warrants, net of issuance costs of $157,504
   
3,374,996
   
1,917,633
 
Proceeds from long-term note payable
   
44,000
   
-
 
Proceeds from exercise of warrants to common stock, net of placement fees of $16,429
   
567,777
   
57,430
 
Payments on loan payable used to finance equipment purchase
   
(7,763
)
 
-
 
Decrease in payables related to debt financing costs
   
-
   
(56,400
)
Proceeds from issuance of convertible notes
   
1,000,000
   
3,155,000
 
Cash financing costs paid for issuance of convertible notes
   
-
   
(167,200
)
Repayment of loans payable
   
-
   
(8,500
)
Payment of payables related to fixed asset purchases
   
(49,406
)
 
-
 
               
Net Cash Provided by Financing Activities
   
4,929,604
   
4,897,963
 
               
Net Increase (Decrease) in Cash and Cash Equivalents
   
(1,043,580
)
 
266,389
 
               
Cash and Cash Equivalents, Beginning of Period
   
1,256,912
   
990,523
 
               
Cash and Cash Equivalents, End of Period
 
$
213,332
 
$
1,256,912
 
               
Supplemental Cash Flow Disclosures:
             
Interest expense paid in cash
 
$
23,401
 
$
445
 
Income tax paid
   
-
   
-
 
               
Supplemental Disclosure of Non-Cash Activities Financing and Investing Activities:
             
Fair value of warrants issued to placement agents for debt financing costs
 
$
65,000
 
$
143,049
 
Fair value of warrants issued with convertible notes
   
134,452
   
1,131,663
 
Fair value of beneficial conversion feature embedded in convertible notes
   
97,164
   
2,023,337
 
Fair value of warrants issued with common stock
   
1,243,087
   
-
 
Fair value of warrants issued to placement agents for equity financing costs
   
277,778
   
-
 
Conversion of preferred stock to common stock
   
-
   
81,411
 
Increase in notes payable related to equipment purchase financing
   
24,377
   
-
 
Decrease in payables related to purchase of fixed assets
   
3,852
   
-
 
Increase in payables related to purchase of fixed assets
   
-
   
49,406
 
Issuance of common stock to satisfy loans payable
   
-
   
20,000
 
Issuance of common stock pursuant to conversion of convertible note payable
   
-
   
50,000
 
Incremental fair value of modified warrants issued pursuant to debt financing
   
25,210
   
-
 
Issuance of common stock for convertible notes payable and accrued interest
   
-
   
4,030,000
 
Increase in payables for debt financing costs
   
70,000
   
-
 

The accompanying notes are an integral part of these financial statements.
 
F-6


QUANTRX BIOMEDICAL CORPORATION
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
 
   
Stock
             
   
Preferred
 
Common
 
Additional
     
Total
 
   
Number of Shares
 
Amount
 
Number of Shares
 
Amount
 
Paid-in
Capital
 
Accumulated Deficit
 
Stockholders’ Equity
 
BALANCE, DECEMBER 31, 2005
   
8,141,147
 
$
81,411
   
18,239,773
 
$
182,397
 
$
23,612,630
 
$
(22,821,723
)
$
1,054,715
 
 
                                           
Exercise of common stock warrants
   
-
   
-
   
85,800
   
858
   
56,572
   
-
   
57,430
 
Conversion of Series A convertible preferred stock to common stock
   
(8,141,147
)
 
(81,411
)
 
12,211,721
   
122,117
   
(40,706
)
 
-
   
-
 
Fair value of stock-based compensation (options)
   
-
   
-
   
-
   
-
   
253,355
   
-
   
253,355
 
Fair value of warrants issued with convertible notes
   
-
   
-
   
-
   
-
   
1,131,663
   
-
   
1,131,663
 
Fair value of embedded beneficial conversion feature of convertible notes
   
-
   
-
   
-
   
-
   
2,023,337
   
-
   
2,023,337
 
Fair value of warrants issued for debt financing costs
   
-
   
-
   
-
   
-
   
143,049
   
-
   
143,049
 
Fair value of warrants issued for consulting
   
-
   
-
   
-
   
-
   
219,000
   
-
   
219,000
 
Issuance of common stock for consulting
   
-
   
-
   
15,000
   
150
   
19,350
   
-
   
19,500
 
Fair value of warrants issued for purchased R&D
   
-
   
-
   
-
   
-
   
100,010
   
-
   
100,010
 
Issuance of common stock in exchange for debt at $0.05 per share
   
-
   
-
   
40,000
   
400
   
19,600
   
-
   
20,000
 
Conversion of notes payable and accrued interest to common stock
   
-
   
-
   
4,745,786
   
47,458
   
4,271,640
   
-
   
4,319,098
 
Issuance of common stock, net of cash issuance costs of $122,367
   
-
   
-
   
2,040,000
   
20,400
   
1,897,233
   
-
   
1,917,633
 
Net loss for the year ended December 31, 2006
   
-
   
-
   
-
   
-
   
-
   
(7,692,514
)
 
(7,692,514
)
 
                                           
BALANCE, DECEMBER 31, 2006
   
-
   
-
   
37,378,080
   
373,780
   
33,706,733
   
(30,514,237
)
 
3,566,276
 
 
                                           
Issuance of common stock, net of cash issuance costs of $157,504
   
-
   
-
   
3,532,500
   
35,325
   
3,339,671
   
-
   
3,374,996
 
Fair value of warrants issued for consulting
   
-
   
-
   
-
   
-
   
316,120
   
-
   
316,120
 
Fair value of employee stock based compensation
   
-
   
-
   
-
   
-
   
219,564
   
-
   
219,564
 
Expenses related to common stock warrants issued
   
-
   
-
   
-
   
-
   
150,902
   
-
   
150,902
 
Fair value of stock based compensation for FP (less minority interest portion)
   
-
   
-
   
-
   
-
   
195,384
   
-
   
195,384
 
Retroactive adjustment for prior year equity method loss (equity method goodwill)
   
-
   
-
   
-
   
-
   
-
   
(829,648
)
 
(829,648
)
Exercise of common stock warrants, net of placement fees of $16,429
   
-
   
-
   
789,101
   
7,891
   
559,886
   
-
   
567,777
 
Fair value of warrants issued with convertible notes
   
-
   
-
   
-
   
-
   
134,452
   
-
   
134,452
 
Fair value of embedded beneficial conversion feature of convertible notes
   
-
   
-
   
-
   
-
   
97,164
   
-
   
97,164
 
Incremental fair value of modified warrants issued pursuant to debt financing
   
-
   
-
   
-
   
-
   
25,210
   
-
   
25,210
 
Fair value of warrants issued for debt financing costs
   
-
   
-
   
-
   
-
   
65,000
   
-
   
65,000
 
Net loss for the year ended December 31, 2007
   
-
   
-
   
-
   
-
   
-
   
(6,044,337
)
 
(6,044,337
)
 
                                           
BALANCE, DECEMBER 31, 2007
   
-
 
$
-
   
41,699,681
 
$
416,996
 
$
38,810,086
 
$
(37,388,222
)
$
1,838,860
 
 
                                           
The accompanying notes are an integral part of these financial statements.
 
F-7


QUANTRX BIOMEDICAL CORPORATION
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
1.
DESCRIPTION OF BUSINESS
 
QuantRx Biomedical Corporation was incorporated on December 5, 1986 in the State of Nevada. The Company’s principal business office is located at 100 South Main Street, Suite 300, Doylestown, Pennsylvania. QuantRx also has a research and development facility in Portland, Oregon.
 
QuantRx is a broad-based diagnostics company focused on the development and commercialization of innovative diagnostic products based on its patented technology platforms for the worldwide healthcare industry. The Company’s strategy is to commercialize its products through partners or distributors, contracting the manufacturing to third party partners while maintaining control over the manufacturing process.
 
In April 2007, QuantRx increased its ownership in FluoroPharma, Inc., a development-stage molecular imaging company, to 57.78% of outstanding capital stock, resulting in its consolidation effective April 1, 2007. When used in these notes, the terms “Company,” “we,” “our,” “ours,” or “us” mean QuantRx Biomedical Corporation, a Nevada corporation, and its subsidiary.
 
2.
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
 
This summary of significant accounting policies of QuantRx Biomedical Corporation is presented to assist in understanding the Company’s financial statements. The financial statements and notes are representations of the Company’s management, which is responsible for their integrity and objectivity. These accounting policies conform to accounting principles generally accepted in the United States of America and have been consistently applied in the preparation of the financial statements.
 
Accounting for Share-Based Payments
 
Effective January 1, 2005, QuantRx adopted Statement of Financial Accounting Standards (SFAS) No. 123(R), “Share-Based Payments” using the modified prospective method of application. SFAS No. 123(R) establishes the accounting for transactions in which an entity exchanges equity securities for services and requires companies to expense the estimated fair value of these awards over the requisite service period. QuantRx uses the Black-Scholes method in determining fair value. Accordingly, compensation cost has been recognized using the fair value method and expected term accrual requirements as prescribed in SFAS No. 123(R), which resulted in stock-based compensation expense related to employees for the year ended December 31, 2007 and 2006 of $235,378 and $253,355, respectively (including $15,814 relating to subsidiary options in 2007).
 
Accounts and Notes Receivable and Bad Debts
 
QuantRx carries its receivables at net realizable value. Interest on notes receivable is accrued based upon the terms of the note agreement. The Company provides reserves against receivables and related accrued interest for estimated losses that may result from a debtor’s inability to pay. The amount is determined by analyzing known uncollectible accounts, economic conditions, historical losses and customer credit-worthiness. Additionally, all accounts with aged balances greater than one year are fully reserved. Amounts later determined and specifically identified to be uncollectible are charged or written off against the reserve. The allowance for bad debts was $214,000 and $0 in 2007 and 2006, respectively.
 
F-8

 
Cash and Cash Equivalents
 
The Company considers all highly liquid investments and short-term debt instruments with maturities of three months or less from date of purchase to be cash equivalents. Cash equivalents consisted of money market funds at December 31, 2007 and 2006.
 
Concentration of Risks
 
The Company maintains its cash and cash equivalents in commercial accounts at a major financial institution. Although the financial institution is considered creditworthy and has not experienced any losses on its deposits as of December 31, 2007, the Company’s cash balances exceeded Federal Deposit Insurance Corporation limits at December 31, 2007 and 2006 by $103,051 and $1,155,512, respectively.
 
Earnings per Share
 
The Company computes net income (loss) per common share in accordance with SFAS No. 128, “Earnings per Share.” Net income (loss) per share is based upon the weighted average number of outstanding common shares and the dilutive effect of common share equivalents, such as options and warrants to purchase common stock, convertible preferred stock and convertible notes, if applicable, that are outstanding each year. Basic and diluted earnings per share were the same at the reporting dates of the accompanying financial statements, as including common stock equivalents in the calculation of diluted earnings per share would have been antidilutive.
 
As of December 31, 2007, the Company had outstanding common stock options of 1,791,750, common stock warrants of 7,113,383, and convertible debt subject to conversion into 1,250,000 shares. The above options, warrants and convertible debt were deemed to be antidilutive for the Company’s year end of December 31, 2007.
 
As of December 31, 2006, the Company had outstanding common stock options of 1,372,500 and common stock warrants of 5,854,484. The above options and warrants were deemed to be antidulitive for the Company’s year end of December 31, 2006.
 
Fair Value of Financial Instruments
 
The Company's financial instruments primarily consist of cash and cash equivalents, prepaid expenses and other deferred charges, short-term accounts and notes receivable, accounts payable, accrued expenses and other current liabilities. All instruments are accounted for on an historical cost basis, which, due to the short maturity of these financial instruments, approximates the fair value at the reporting dates of these financial statements.
 
In determining fair value of our cost method investment, QuantRx estimated fair value based on historical experience and on various other assumptions that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of this investment that are not readily apparent from other sources. QuantRx has determined that the carrying value for its cost method investment approximates fair value.
 
Property and Equipment
 
Property and equipment are stated at cost. Depreciation is computed using the straight-line method over the estimated useful lives of the assets. The Company’s property and equipment at December 31, 2007 and 2006 consisted of computer and office equipment, machinery and equipment and leasehold improvements with estimated useful lives of three to seven years. Estimated useful lives of leasehold improvements do not exceed the remaining lease term. Depreciation expense was $81,932 and $13,511 for the years ended December 31, 2007 and 2006. Expenditures for repairs and maintenance are expensed as incurred.
 
F-9

 
Income Taxes
 
The Company accounts for income taxes and the related accounts under the liability method. Deferred tax assets and liabilities are determined based on the differences between the financial statement carrying amounts and the income tax bases of assets and liabilities. A valuation allowance is applied against any net deferred tax asset if, based on available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized.
 
In July 2006, FASB issued FASB Interpretation No. (FIN) 48, “Accounting for Uncertainty in Income Taxes - an Interpretation of FASB Statement 109,” which clarifies the accounting for uncertainty in tax positions. Under FIN 48, the impact of an uncertain income tax position on the income tax return must be recognized at the largest amount that is more-likely-than-not to be sustained upon audit by the relevant taxing authority. An uncertain income tax position will not be recognized if it has less than a 50% likelihood of being sustained. Additionally, FIN 48 provides guidance on derecognition, classification, interest and penalties, accounting in interim periods, disclosure and transition. We adopted the provisions of FIN 48 on January 1, 2007. There were no unrecognized tax benefits as of the date of adoption. As a result of the implementation of FIN 48, we did not recognize an increase in the liability for unrecognized tax benefits. There are no unrecognized tax benefits included in the consolidated balance sheet that would, if recognized, affect the effective tax rate. The adoption of FIN 48 did not impact our consolidated financial condition, results of operations or cash flows.
 
Our policy is to recognize interest and/or penalties related to income tax matters in income tax expense. We had no accrual for interest or penalties on our consolidated balance sheets at December 31, 2007 or 2006, and have not recognized interest and/or penalties in the consolidated statement of operations for the year ended December 31, 2007. See Note 11, Income Taxes.
 
Impairments
 
The Company assesses the impairment of long-lived assets, including other intangible assets, whenever events or changes in circumstances indicate that their carrying value may not be recoverable in accordance with SFAS No. 144, “Accounting for the Impairment or Disposal of Long-Lived Assets.” The determination of related estimated useful lives and whether or not these assets are impaired involves significant judgments, related primarily to the future profitability and/or future value of the assets. The Company holds investments in companies having operations or technologies in areas which are within or adjacent to our strategic focus when acquired, all of which are privately held and whose values are difficult to determine. The Company records an investment impairment charge if it believes an investment has experienced a decline in value that is other than temporary.
 
The Company performed annual impairment tests of our equity method goodwill in accordance with SFAS No. 142, “Goodwill and Other Intangible Assets.” Under SFAS No. 142, equity method goodwill is not amortized but is subject to impairment tests in accordance with Accounting Principles Board Opinion No. 18, “The Equity Method of Accounting for Investments in Common Stock,” under which QuantRx would have recognized an impairment loss had there been a loss in the value of the equity method goodwill which was deemed to be other than a temporary decline. See Note 3 for additional information.
 
F-10

 
Management has determined that no impairments were required during the years ended December 31, 2007 and 2006, respectively.
 
Intangible Assets
 
The Company’s intangible assets consist of patents, patents under licensing, website development costs, and acquired intangibles, and are carried at the legal cost to obtain them. Intangible assets are amortized using the straight line method over the estimated useful life. Useful lives are as follows: patents, 17 years; patents under licensing, 10 years; website development costs, three years, and; acquired intangibles, estimated remaining useful life, between eight and 15 years. Amortization expense totaled $132,875 and $7,560 for the years ended December 31, 2007 and 2006, respectively. The estimated aggregate amortization expense for 2008 through 2012 is $177,485; $177,249; $169,702; $164,102; and $164,102.
 
Principles of Consolidation
 
These consolidated financial statements include the accounts of the Company and, from April 1, 2007, its majority-owned subsidiary, FluoroPharma, Inc. All significant intercompany accounts and transactions have been eliminated in consolidation. See Note 3 for additional information.
 
Recent Accounting Pronouncements
 
In December 2007, the Financial Accounting Standard Board (FASB) issued SFAS No. 160, "Noncontrolling Interest in Consolidated Financial Statements, an amendment of ARB No. 51," which will change the accounting and reporting for minority interests, which will be recharacterized as noncontrolling interests and classified as a component of equity within the consolidated balance sheets. SFAS No. 160 is effective as of the beginning of the first fiscal year beginning on or after December 15, 2008. Earlier adoption is prohibited and the Company is currently evaluating the effect, if any, that the adoption will have on its consolidated results of operations or financial position.
 
In December 2007, the FASB issued SFAS No. 141(R), “Business Combinations.” SFAS No. 141(R) will change the accounting for business combinations. Under SFAS No. 141(R), an acquiring entity will be required to recognize all the assets acquired and liabilities assumed in a transaction at the acquisition-date at fair value with limited exceptions. SFAS No. 141(R) will change the accounting treatment and disclosure for certain specific items in a business combination. SFAS No. 141(R) applies prospectively to business combinations for which the acquisition date is on or after the beginning of the first annual reporting period beginning on or after December 15, 2008. Accordingly, any business combinations the Company engages in will be recorded and disclosed following existing GAAP until January 1, 2009. QuantRx expects SFAS No. 141(R) will have an impact on accounting for business combinations once adopted but the effect is dependent upon acquisitions at that time. QuantRx is still assessing the impact of SFAS No. 141(R).
 
In November 2007, the Emerging Issues Task Force (EITF) issued EITF No. 07-01, “Accounting for Collaborative Arrangements.” EITF No. 07-01 requires collaborators to present the results of activities for which they act as the principal on a gross basis and report any payments received from (made to) other collaborators based on other applicable GAAP or, in the absence of other applicable GAAP, based on analogy to authoritative accounting literature or a reasonable, rational, and consistently applied accounting policy election. Further, EITF 07-01 clarified that transactions within a collaborative arrangement that are part of a vendor-customer (or analogous) relationship are subject to Issue 01-9, “Accounting for Consideration Given by a Vendor to a Customer.” EITF 07-01 is effective for fiscal years beginning December 15, 2008. QuantRx does not expect the adoption of EITF 07-01 to have a material impact on the Company’s consolidated results of operations or financial position.
 
F-11

 
In June 2007, the FASB ratified the EITF consensus on EITF No. 07-3, “Accounting for Nonrefundable Advance Payments for Goods or Services Received for Use in Future Research and Development Activities.” EITF 07-3 provides that nonrefundable advance payments for goods or services that will be used or rendered for future research and development activities should be capitalized and deferred. Such amounts should be recognized as an expense as the related goods are delivered or the related services are performed or such time when an entity does not expect the goods to be delivered or services to be performed. EITF 07-3 is effective for fiscal periods beginning after December 15, 2007. QuantRx does not expect the adoption of EITF 07-3 to have a material impact on the Company’s consolidated results of operations or financial position.
 
In February 2007, the FASB issued SFAS No. 159, “The Fair Value Option for Financial Assets and Financial Liabilities - Including an Amendment to FASB Statement No. 115.” This standard permits an entity to choose to measure many financial instruments and certain other items at fair value at specified election dates and applies to all entities with available-for-sale and trading securities. Implementation of this statement is required in the first quarter of 2008. QuantRx does not expect this statement to have a material impact on the Company’s consolidated results of operations or financial position.
 
In September 2006, the FASB issued SFAS No. 157, "Fair Value Measurements," to clarify how to measure fair value and to expand disclosures about fair value measurements. Implementation is required in the first quarter of 2008 with any changes to the fair values of assets or liabilities to be reported generally in net income or in accumulated comprehensive income for the period. QuantRx does not expect this statement to have a material impact on the Company’s consolidated results of operations or financial position.
 
In February 2006, the FASB issued SFAS No. 155, “Accounting for Certain Hybrid Financial Instruments, an Amendment of FASB Standards No. 133 and 140.” This statement established the accounting for certain derivatives embedded in other instruments and was effective for fiscal years beginning after September 15, 2006. This statement has had no impact on the Company’s financial condition or results of operations.
 
Reclassifications
 
Certain amounts from prior periods have been reclassified to conform to the current period presentation. This reclassification has resulted in no changes to the Company’s accumulated deficit or net losses presented.
 
Research and Development Costs
 
Research and development costs are expensed as incurred. The cost of intellectual property purchased from others that is immediately marketable or that has an alternative future use is capitalized and amortized as intangible assets. Capitalized costs are amortized using the straight-line method over the estimated economic life of the related asset.
 
F-12

 
Revenue Recognition
 
The Company recognizes revenue in accordance with SEC Staff Accounting Bulletin Topic 13 when persuasive evidence of an arrangement exists and delivery or performance has occurred, provided the fee is fixed or determinable and collection is probable. The Company assesses whether the fee is fixed and determinable based on the payment terms associated with the transaction. If a fee is based upon a variable such as acceptance by the customer, the Company accounts for the fee as not being fixed and determinable. In these cases, the Company defers revenue and recognizes it when it becomes due and payable. Up-front engagement fees are recorded as deferred revenue and amortized to income on a straight-line basis over the term of the agreement, although the fee is due and payable at the time the agreement is signed or upon annual renewal. Payments related to substantive, performance-based milestones in an agreement are recognized as revenue upon the achievement of the milestones as specified in the underlying agreement when they represent the culmination of the earnings process. The Company assesses the probability of collection based on a number of factors, including past transaction history with the customer and the current financial condition of the customer. If the Company determines that collection of a fee is not reasonably assured, revenue is deferred until the time collection becomes reasonably assured.
 
The Company recognizes revenue from nonrefundable minimum royalty agreements from distributors or resellers upon delivery of product to the distributor or reseller, provided no significant obligations remain outstanding, the fee is fixed and determinable, and collection is probable. Once minimum royalties have been received, additional royalties are recognized as revenue when earned based on the distributor’s or reseller’s contractual reporting obligations. Royalty revenue totaled $51,364 for 2007 and 2006.
 
The Company’s strategy includes entering into collaborative agreements with strategic partners for the development, commercialization and distribution of its product candidates. Such collaboration agreements may have multiple deliverables. The Company evaluates multiple deliverable arrangements pursuant to EITF 00-21, “Revenue Arrangements with Multiple Deliverables.” Pursuant to EITF 00-21, in arrangements with multiple deliverables where the Company has continuing performance obligations, contract, milestone and license fees are recognized together with any up-front payments over the term of the arrangement as performance obligations are completed, unless the deliverable has stand alone value and there is objective, reliable evidence of fair value of the undelivered element in the arrangement. In the case of an arrangement where it is determined there is a single unit of accounting, all cash flows from the arrangement are considered in the determination of all revenue to be recognized. Cash received in advance of revenue recognition is recorded as deferred revenue.
 
Branan Medical Corporation
 
In 2000, QuantRx and Branan Medical Corporation signed a world-wide license agreement for QuantRx’s RapidSense technology, specifically for the purpose of making, using and offering for sale saliva tests for “Drugs of Abuse.” The agreement terminates upon expiration of the RapidSense technology patents (currently in 2023), but may be terminated by either party with 60 days notice. QuantRx is entitled to royalties of 5% on net sales of licensed products by Branan, with a monthly minimum royalty payment of $4,280. QuantRx has no further obligations under this license; and therefore, recognizes these royalties when due and payable.
 
F-13

 
Synova Healthcare, Inc.
 
On July 7, 2006 (the effective date), QuantRx and Synova Healthcare, Inc. (Synova) entered into a distribution agreement pursuant to which Synova would act as the exclusive distributor of specified hemorrhoid products of QuantRx in the United States. The initial term of the agreement was to commence on the effective date and, unless sooner terminated as provided in the agreement, was to continue in effect for a period of five years following the month in which Synova made its first shipment of products to its initial customers. Management estimated the effective term of the agreement to be six years from the effective date.
 
QuantRx received an up-front, non-refundable payment of $500,000 upon execution of the distribution agreement, which was recorded as deferred revenue and was amortized into revenue over the expected term of the agreement, which was six years. QuantRx recognized revenue of $459,901 and $40,099 in 2007 and 2006, respectively. In December 2007, in accordance with the terms of the distribution agreement, QuantRx delivered notice of termination of the agreement and recognized the remaining deferred revenue at that time of $383,513.
 
Development Agreements
 
In 2007 QuantRx entered into two development agreements to develop rapid test POC products in oral care for ALT BioScience (ALT), and a female fertility test jointly with a major consumer health company. QuantRx recognized revenues $235,146 related to these agreements in accordance with its revenue recognition policies, and costs of approximately $346,845.
 
The ALT agreement, and subsequent renewals, commenced March 2007 and stipulated an up front fee, recognized over the initial five month term, and monthly fees. The current agreement terminates October 31, 2008, with automatic 30 day renewals, subject to termination with 45 days notice. The agreement grants QuantRx certain manufacturing rights for the developed products, which shall be negotiated in good faith in a separate manufacturing agreement upon the completion of design and verification testing. 
 
The second development agreement entered into in 2007 was accounted for using the Performance Method - Expected Revenue. The agreement included an up front payment which was recognized fully in 2007, and stipulates milestone based payments, one of which was recognized in 2007, as well as certain royalty rights upon meeting the product requirements as mutually agreed upon in the development plan and subsequent commercialization. Should the decision be made to proceed toward commercialization by the counterparty, a separate definitive licensing agreement shall be negotiated in good faith specifying details of the royalty rights contained in the development agreement.
 
 
The accompanying financial statements are prepared in conformity with accounting principles generally accepted in the United States of America, and include certain estimates and assumptions which affect the reported amounts of assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. Accordingly, actual results may differ from those estimates.
 
F-14

 
3.
CONSOLIDATION OF FLUOROPHARMA, INC.
 
In March 2006, QuantRx purchased 1,096,170 shares of FluoroPharma common stock for a total purchase price of $1,566,023. Contemporaneously, QuantRx negotiated the purchase of an additional 300,000 shares from private investors for $429,000. In February 2007, QuantRx purchased an additional 200,000 shares from private investors for $286,000. On April 13, 2007, QuantRx and FluoroPharma closed the transactions contemplated by a “stage 2” investment agreement. Under the investment agreement, effective April 1, 2007, QuantRx purchased 627,058 shares of common stock of FluoroPharma for $1,250,000, consisting of (i) cash payments aggregating $741,178; and (ii) cancellation in full of two promissory notes issued by FluoroPharma in favor of QuantRx, in the aggregate principal amount of $500,000, and with accrued and unpaid interest of $8,822, for a total of $508,822. As a result of these equity purchases, QuantRx’s ownership in FluoroPharma exceeded 50%, requiring QuantRx to consolidate FluoroPharma. FluoroPharma, Inc. is a privately held molecular imaging company based in Boston, Massachusetts, engaged in the discovery, development, and commercialization of proprietary products for positron emission tomography. The investment in FluoroPharma is intended to strategically expand QuantRx’s diagnostic platforms.
 
As of December 31, 2007, QuantRx owned approximately 57.78% of the issued and outstanding capital stock of FluoroPharma. Effective April 1, 2007, FluoroPharma’s results of operations have been included in the accompanying consolidated financial statements.
 
The investment in FluoroPharma of $1,995,023 at December 31, 2006, and until the date of consolidation, was accounted for in accordance with the equity method of accounting. Since FluoroPharma’s liabilities exceeded assets on the investment dates, each investment was recorded as equity method goodwill. In accordance with SFAS No. 142, equity method goodwill is not amortized or tested for impairment in accordance with this standard. QuantRx reviewed the equity method goodwill in accordance with APB Opinion No. 18 under which QuantRx would have recognized an impairment loss had there been a loss in the value of the equity method goodwill which was deemed to be other than a temporary decline. No impairment was recognized through March 31, 2007.
 
QuantRx is not accounting for the acquisition of FluoroPharma’s equity as a business combination since FluoroPharma is a development-stage enterprise and does not meet the definition of a business in accordance with SFAS No. 141, “Business Combinations” and EITF 98-3, “Determining Whether a Nonmonetary Transaction Involves Receipt of Productive Assets or of a Business.” As a result of the consolidation and pursuant to Accounting Research Bulletin (ARB) No. 51, “Consolidated Financial Statements,” effective April 1, 2007, QuantRx recognized previously unrecognized equity method losses relating to its investment in FluoroPharma of $829,648, attributable to 2006, as an adjustment to retained earnings, and $267,608, attributable to 2007, in the second quarter of 2007. These losses were previously unrecognized since APB No. 18 stipulated that the entire investment be treated as equity method goodwill with no equity method loss recognition.
 
F-15

 
QuantRx’s aggregate investment in the equity of FluoroPharma of $3,531,023 was reduced at April 1, 2007, by the $1,097,256 in previously unrecognized equity method losses required to be recorded upon consolidation in accordance with ARB No. 51. The remaining investment balance of $2,433,767 at April 1, 2007, has been allocated upon consolidation based on fair value estimates as follows:
 
Cash
 
$
764,223
 
Prepaid expenses
   
99,980
 
Property and equipment
   
62,802
 
Intangible assets
   
2,134,783
 
Current liabilities
   
(352,733
)
Minority interests
   
(275,288
)
   
$
2,433,767
 
 
Acquired intangibles primarily consist of licensed patent rights and technology licenses and are estimated to have a weighted average life of 15 years. Amortization expense related to these intangibles (subsequent to the acquisition) in the year ending December 31, 2007, was $114,044.
 
Minority interests of $275,288 at April 1, 2007, resulted from the consolidation of FluoroPharma reflecting the interests held by third parties of FluoroPharma. Since acquisition, and as of December 31, 2007, the portion of FluoroPharma’s losses attributable to the minority interest have been recorded, reducing the minority interest to zero.
 
In the third and fourth quarters of 2007, QuantRx advanced an aggregate of $600,000 to FluoroPharma through five convertible promissory notes due within twelve months. These notes and accrued interest of $14,252 for the year ended December 31, 2007, were eliminated in consolidation.
 
Under the initial investment agreement with FluoroPharma, QuantRx has the option to acquire additional shares of FluoroPharma through a series of staged investments. Such staged investments will take the form of cash at increasing valuations upon FluoroPharma’s achievement of certain milestones with respect to the successful completion of Phase I and Phase II FDA trials for certain compounds being developed by FluoroPharma. The final staged investment to wholly acquire FluoroPharma will be settled in QuantRx’s common stock. Any subsequent investment in FluoroPharma by QuantRx will be consummated pursuant to the terms and subject to the conditions set forth in separate definitive agreements.
 
In connection with the initial investment, QuantRx received an option to purchase an additional 260,000 shares of FluoroPharma common stock at an exercise price of $0.75. FluoroPharma has outstanding common stock equivalents which, if exercised together with the Company’s option and convertible notes, would reduce the Company’s ownership percentage to approximately 52.19% on a fully diluted and as converted basis as of December 31, 2007.
 
F-16

 
 
4. OTHER BALANCE SHEET INFORMATION
 
Components of selected captions in the accompanying balance sheets as of December 31, 2007 and 2006 consist of:
 
   
2007
 
2006
 
Prepaid expenses:
          
Prepaid consulting
 
$
159,410
 
$
73,000
 
Prepaid consulting - related party
   
17,377
   
-
 
Prepaid insurance
   
31,829
   
30,313
 
Prepaid press releases
   
3,780
   
2,538
 
Prepaid rent
   
5,310
   
5,310
 
Other
   
9,316
   
2,225
 
Prepaid expenses
 
$
227,022
 
$
113,386
 
               
Property and equipment:
             
Computers and office furniture, fixtures and equipment
 
$
148,141
 
$
84,129
 
Machinery and equipment
   
252,681
   
37,104
 
Leasehold improvements
   
92,233
   
51,228
 
Less: accumulated depreciation
   
(101,335
)
 
(15,638
)
Property and equipment, net
 
$
391,720
 
$
156,823
 
               
Accrued expenses:
             
Professional fees
 
$
72,050
 
$
30,000
 
Clinical trials
   
110,833
   
-
 
Other
   
50,400
   
11,692
 
Accrued expenses
 
$
233,283
 
$
41,692
 
 
5. NOTES RECEIVABLE
 
FluoroPharma, Inc.
 
In February 2007 and December 2006, QuantRx advanced an aggregate of $500,000 to FluoroPharma through two $250,000, 8% promissory notes due May 16 and March 31, 2007, respectively. QuantRx accrued interest of $7,836 on these notes for the year ended December 31, 2007. The principal balances and unpaid accrued interest were settled through a staged investment transaction in the second quarter of 2007; see Note 3.
 
Genomics USA, Inc.
 
In January 2007, QuantRx advanced $200,000 to Genomics USA, Inc. (GUSA) through an 8% promissory note due April 8, 2007. The note is currently convertible at QuantRx’s discretion into 10% of GUSA’s outstanding capital stock on a fully diluted and as converted basis. QuantRx is currently exploring the possibility of further investment, and has postponed settlement of the note during this exploratory period, during which the note shall continue to accrue interest. QuantRx accrued interest of $15,649 on this note for the year ended December 31, 2007. GUSA, a privately held Illinois corporation, is a technology company focused on the development of Micro-Array Detection for DNA. This technology may strategically expand QuantRx’s diagnostic platforms. See Note 6 for additional information on GUSA.
 
F-17

 
Rockland Technimed, Ltd.
 
In April 2006, QuantRx advanced $200,000 to Rockland Technimed, Ltd. (Rockland) through a 7% convertible promissory note due twelve months from the date of issuance. Rockland, a privately held Delaware corporation, is a development stage company focused on the research and development of tissue viability imaging diagnostics using magnetic resonance imaging (MRI) scanners. QuantRx has accrued interest of $4,083 for the year ended December 31, 2007. The note is convertible at QuantRx’s discretion into 20% of Rockland’s outstanding capital stock on a fully diluted and as converted basis to satisfy the note and accrued interest. QuantRx ceased accruing interest as of the maturity date and established an allowance for bad debt in the amount equal to the principal balance and accrued interest, $214,000, as the Company attempts to resolve this matter.
 
6. INVESTMENTS
 
Genomics USA, Inc.
 
In May 2006, QuantRx purchased 144,024 shares of GUSA common stock for $200,000. As of December 31, 2007, QuantRx owned approximately 10% of the issued and outstanding capital stock of GUSA on a fully diluted and as converted basis.
 
QuantRx uses the cost method to account for this investment since QuantRx does not control nor have the ability to exercise significant influence over operating and financial policies. In accordance with the cost method, the investment is recorded at cost and impairment is considered in accordance with the Company’s impairment policy. No impairment was recognized for the year ended December 31, 2007.
 
7. INTANGIBLE ASSETS
 
Intangible assets as of December 31, 2007 and 2006 consisted of the following: 
 
     
2007
   
2006
 
Licensed patents and patent rights
 
$
2,168,305
 
$
50,000
 
Patents
   
82,008
   
82,008
 
Technology license
   
22,517
   
-
 
Website development
   
49,111
   
8,500
 
Less: accumulated amortization
   
(159,716
)
 
(26,839
)
Intangibles, net
 
$
2,162,225
 
$
113,669
 
 
Acquired Intangibles
 
In April 2007, QuantRx obtained a majority interest in FlouroPharma, resulting in $2,134,783 allocated to acquired intangible assets based upon estimated fair values as of the purchase date. These acquired intangibles primarily consist of licensed patent rights and technology licenses and are estimated to have a weighted average life of 15 years.
 
Patent under Licensing
 
In the second quarter of 2006, QuantRx entered into a patent license agreement with The Procter & Gamble Company, effective July 1, 2006. The agreement licenses patent rights and know-how for certain hemorrhoid treatment pads and related coatings. The term of the agreement is five years with a five year automatic renewal option. In consideration of this agreement, QuantRx paid a one-time, non-refundable engagement fee, and will pay royalties based on future net sales of such licensed products.
 
F-18

 
The Company has capitalized this engagement fee and will amortize the capitalized cost over the expected term of the patent license agreement. Amortization of $5,000 and $2,500 in connection with this licensed patent was recognized in the years ended December 31, 2007 and 2006. All royalties due pursuant to the terms of the agreement will be expensed as incurred. Impairment will be considered in accordance with the Company’s impairment policy. No impairment was recognized as of December 31, 2007.
 
8. PORTLAND DEVELOPMENT COMMISSION
 
In February 2007, QuantRx received a $44,000 loan from the Portland Development Commission. The loan matures in 20 years and is interest free through March 1, 2010, and no payments are due until April 1, 2010. The terms of the promissory note stipulate that the interest rate will accrue beginning in March 1, 2010, at an annual rate between 1% and 8.5% based upon the level of compliance with certain employment milestones beginning in 2008.
 
Additionally, QuantRx received a $14,000 grant for qualified expenditures related to its research facility. QuantRx satisfied the grant terms and recorded the grant as other income.
 
9. CONVERTIBLE DEBT 
 
2007 Convertible Promissory Notes
 
On October 16, 2007, QuantRx completed a private placement of 10% senior secured convertible promissory notes and warrants to purchase shares of QuantRx' common stock. In connection with the private placement, QuantRx issued notes in the aggregate principal amount of $1,000,000 and warrants to purchase 250,000 shares of QuantRx' common stock at an exercise price of $1.25 (relative fair value of $134,454). Proceeds of the financing will be used for general corporate purposes. The notes and the warrants were offered only to certain private accredited investors.
 
These convertible notes are automatically convertible into shares of QuantRx common stock upon completion of a “qualified” equity financing (or financings) with aggregate gross proceeds of at least $4,000,000 (amount to be reduced by these convertible promissory notes, up to a maximum of $2,000,000). Under the terms of the convertible notes, holders of the notes will be deemed to have tendered 115% of their aggregate outstanding principal balance and accrued interest for purchase of securities in the qualified equity financing, entitling the holders to all rights afforded to purchasers in such financing (“contingent embedded conversion option”). Alternatively, the convertible notes allow the holders to convert their outstanding principal and accrued interest into common stock at a price of $0.80 per common share (“embedded conversion option”). Either conversion would result in the satisfaction of all of QuantRx’s obligations under the convertible notes.
 
In the event QuantRx does not complete a qualified financing and holders do not voluntarily convert, QuantRx must repay the outstanding principal balance and accrued and unpaid interest on October 31, 2008. At the payee’s option, accrued interest may be converted to additional senior secured promissory notes. QuantRx has the right to prepay the promissory notes at 115% of face value and 100% of accrued interest by providing ten days notice.
 
F-19

 
In accordance with APB Opinion No. 14, “Accounting for Convertible Debt and Debt Issued with Stock Purchase Warrants,” QuantRx allocated $134,454 of the principal amount of the 10% convertible promissory notes to the warrants as original issue discount, which represented the relative fair value of the warrants at the date of issuance.
 
The embedded conversion option described above is not considered a derivative instrument and is not required to be bifurcated pursuant to the scope exception in paragraph 11(a) of SFAS No. 133, “Accounting for Derivative Instruments and Hedging Activities,” since it is indexed to QuantRx’s stock and is classified as stockholders’ equity. Equity classification of the embedded conversion options is met through the requirements of EITF 00-19, “Accounting for Derivative Financial Instruments to, and Potentially Settled in, a Company’s Own Stock,” paragraphs 12-32. QuantRx also concluded, pursuant to EITF 00-27, “Application of Issue 98-5 to Certain Convertible Instruments,” that while the embedded conversion option is not required to be bifurcated, the instruments do contain a beneficial conversion feature, as the share prices on the dates of issuance exceeded the effective conversion price of the embedded conversion options. QuantRx measured the intrinsic value of the “embedded conversion option” ($97,164) based upon the effective conversion price, which is defined by EITF 00-27, “Application of Issue 98-5 to Certain Convertible Instruments,” as the allocated proceeds divided by the number of shares to be received on conversion. This amount was recorded as original issue discount.
 
The contingent embedded conversion option qualifies as an embedded contingent conversion option in accordance with EITF 98-5 and 00-27 since execution of the contingent embedded conversion option is contingent upon a qualified equity financing and is not within the control of QuantRx. The intrinsic value of the contingent embedded conversion option will not be recognized until and unless such financing occurs (the triggering event); which will then enable QuantRx to measure the intrinsic value associated with the automatic conversion feature.
 
In connection with this transaction, certain warrants that were previously issued to the note holders were modified by reducing their exercise price from $1.50 to $0.75. The incremental fair value of this modification, accounted for in accordance with SFAS No. 123(R), was $30,000, while the relative fair value was calculated to be $25,210 and was recorded as additional original issue discount.
 
In association with the issuance of these convertible notes, QuantRx issued warrants to purchase 100,000 shares of common stock at $1.10 per share valued at $65,000 to the placement agent, and also incurred cash commissions of $70,000 in connection with the private placement resulting in total deferred debt offering cost of $135,000.
 
The fair value of the warrants issued to placement agents and the cash commissions have been recorded as deferred financing costs. The total original issue discount related to the warrants issued to the investors, the modified warrants and the beneficial conversion feature and the deferred financing costs are being amortized to interest expense over the term of the convertible promissory notes in accordance with EITF 00-27, paragraph 19. Interest expense, including amortization of original issue discount and deferred financing costs, related to the 10% convertible promissory notes was $101,168 for the year ended December 31, 2007.
 
The Black-Scholes option pricing model was used to calculate the fair values of all of the above warrants.
 
F-20

 
2006 Convertible Promissory Notes
 
On February 15, 2006, QuantRx closed on $4,030,000 of 8% unsecured convertible promissory notes due December 31, 2006, to certain private accredited investors, of which $3,155,000 were issued in the first quarter of 2006, and $875,000 issued in the fourth quarter of 2005, respectively. Also, investors received vested warrants with a five year term to purchase an aggregate of 854,500 shares of QuantRx common stock at an exercise price of $1.50 (valued at $1,339,694), of which 723,250 warrants (valued at $1,131,663) were issued in the first quarter of 2006, and 131,250 (valued at $208,031) issued in the fourth quarter of 2005, respectively.
 
On December 6, 2006, QuantRx closed on a “qualified” financing which triggered the conversion of all outstanding convertible promissory notes and related accrued interest into shares of common stock pursuant to the terms of the notes. Additionally, in the third quarter of 2006, one note holder elected to convert his outstanding balance and related accrued interest into shares of common stock pursuant to the terms of the note. The aggregate outstanding principal balance of $4,030,000 and related accrued interest of $289,118 was converted in 2006 into 4,745,786 shares of common stock. Upon automatic conversion on December 6, 2006, note holders received warrants to purchase 1,408,037 with an exercise price of $1.50 and a term of three years.
 
These convertible notes were automatically convertible into shares of QuantRx common stock upon completion of a “qualified” equity financing (or financings) with aggregate gross proceeds of at least $2,000,000. Under the terms of the convertible notes, holders of the notes were deemed to have tendered 110% of their aggregate outstanding principal balance and accrued interest for purchase of securities in the qualified equity financing, entitling the holders to all rights afforded to purchasers in such financing (“contingent embedded conversion option”). Alternatively, the convertible notes allowed the holders to convert their outstanding principal and accrued interest into common stock at a price of $1.00 per common share no earlier than six months after the issuance of the promissory notes (“embedded conversion option”). Either conversion resulted in the satisfaction of all of QuantRx’s obligations under the convertible notes.
 
In the event QuantRx did not complete a qualified financing and holders did not voluntarily convert, QuantRx was required to pay the outstanding principal balance and accrued and unpaid interest on December 31, 2006. Accrued interest was payable at QuantRx’s option in cash or common stock.
 
In accordance with APB No. 14, QuantRx allocated $1,339,694 of the principal amount of the 8% convertible promissory notes to the warrants as original issue discount, which represented the relative fair value of the warrants at the dates of issuance.
 
The embedded conversion options described above were not considered derivative instruments and were not required to be bifurcated pursuant to the scope exception in paragraph 11(a) of SFAS No. 133, since they were indexed to QuantRx’s stock and were classified as stockholders’ equity. Equity classification of the embedded conversion options was met through the requirements of EITF 00-19, paragraphs 12-32. QuantRx also concluded, pursuant to EITF 00-27, that while the embedded conversion options were not required to be bifurcated, the instruments did contain a beneficial conversion feature, as the share prices on the dates of issuance exceeded the effective conversion price of the embedded conversion options. QuantRx measured the intrinsic value of the “embedded conversion option” ($3,697,444) based upon the effective conversion price, which is defined by EITF 00-27, as the allocated proceeds divided by the number of shares to be received on conversion. The intrinsic value of this beneficial conversion feature was limited to the remaining allocated proceeds of $2,690,306, which represented gross proceeds less the relative fair value of $1,339,694 allocated to the detachable warrants. This amount was recorded as original issue discount, of which $2,023,337 relates to the convertible notes issued in the first quarter of 2006 and $666,969 relates to the notes issued in the fourth quarter of 2005. The remaining intrinsic value of $1,007,138 related to the embedded conversion feature represents the excess of the aggregate fair value of the instruments that the holder would receive at conversion over the proceeds received.
 
F-21

 
The “contingent embedded conversion option” qualified as an embedded contingent conversion option in accordance with EITF 98-5 and 00-27 since execution of the automatic conversion feature was contingent upon a qualified equity financing and was not within the control of QuantRx. Upon automatic conversion, QuantRx measured the intrinsic value of the automatic conversion feature ($3,691,172) based upon the effective conversion price on December 6, 2006. The remaining intrinsic value of $1,034,244 related to the contingent embedded conversion feature represents the excess of the aggregate fair value of the instruments that the holders received at conversion over the proceeds received. This amount was not recognized, as QuantRx previously fully allocated the aggregate gross proceeds.
 
In association with the issuance of these convertible notes, QuantRx issued warrants for services to purchase 135,680 shares of common stock at $1.50 per share valued at $214,564, of which 90,560 warrants valued at $143,049 were issued in the first quarter of 2006, with the remainder issued in the fourth quarter of 2005. QuantRx also incurred cash commissions of $223,600 in connection with the private placement to various placement agents resulting in total deferred debt offering cost of $438,164, of which $310,249 relates to the notes issued in the first quarter of 2006, with the remainder relating to notes issued in the fourth quarter of 2005.
 
The fair value of the warrants issued to placement agents and the cash commissions have been recorded as deferred financing costs. The total original issue discount related to the warrants issued to the investors and the beneficial conversion feature and the deferred financing costs are being amortized to interest expense over the term of the convertible promissory notes in accordance with EITF 00-27, paragraph 19. Pursuant to the conversion of all outstanding convertible promissory notes, all previously unamortized deferred finance costs and debt discount was expensed in its entirety. Interest expense, including amortization of original issue discount and deferred financing costs, related to the 8% convertible promissory notes was $4,724,335 for the year ended December 31, 2006 and $32,948 for the year ended December 31, 2005.
 
The Black-Scholes option pricing model was used to calculate the fair values of all of the above warrants.
 
10. COMMITMENTS AND CONTINGENCIES
 
Operating Leases
 
The Company has operating leases for its office and research and development space, both of which have initial lease terms of five years. The corporate office lease contains an option for QuantRx to terminate the lease after the third year for a fee of $5,000. Certain leases contain rent escalation clauses that require higher rental payments in later years. Leases may also contain rent holidays, or free rent periods, during the lease term.
 
Rent expense is recognized on a straight-line basis over the initial lease term. Leasehold improvements have been included in fixed assets. Rent expense relating to our operating leases was $119,396 and $76,615 for the years ended December 31, 2007 and 2006, respectively. Minimum lease payments for the years 2008 through 2012 are as follows: $122,263; $101,563; $57,240; $43,875; and $0; and in the aggregate is $324,941. Sublease income relating to our operating leases was $20,009 and $0 for the years ending December 31, 2007 and 2006, and is recorded in other income.
 
F-22

 
Executive Employment Contracts
 
The Company has entered into an employment contract with a key Company executive that provides for the continuation of salary to the executive if terminated for reasons other than cause, as defined in those agreements. At December 31, 2007, the future employment contract commitment for such key executive based on this termination clause was approximately $240,000.
 
11. INCOME TAXES
 
We are subject to taxation in the U.S., the Commonwealth of Pennsylvania, and the states of Oregon and Massachusetts. With few exceptions, the Company is no longer subject to U.S. federal, state and local income tax examinations by tax authorities for years before 2002.
 
At December 31, 2007 and 2006, the Company had gross deferred tax assets calculated at an expected blended rate of 38% of approximately $13,942,444 and $10,923,448 respectively, principally arising from net operating loss carryforwards for income tax purposes. As management of the Company cannot determine that it is more likely than not that the Company will realize the benefit of the deferred tax asset, a valuation allowance of $13,917,226 and $10,923,448 has been established at December 31, 2007 and 2006, respectively.
 
Additionally, the future utilization of our net operating loss and R&D credit carryforwards to offset future taxable income may be subject to an annual limitation, pursuant to IRC Sections 382 and 383, as a result of ownership changes that may have occurred previously or that could occur in the future.
 
The significant components of the Company’s net deferred tax assets (liabilities) at December 31, 2007 and 2006 are as follows:
 
   
2007
 
 2006
 
Gross deferred tax assets:
             
Net operating loss carryforwards
 
$
12,472,607
 
$
9,382,821
 
Stock based expenses
   
1,136,836
   
1,479,019
 
Tax credit carryforwards
   
247,303
   
61,608
 
All others
   
85,698
   
-
 
     
13,942,444
   
10,923,448
 
Gross deferred tax liabilities:
             
Difference between book and tax bases of tangible and intangible assets
   
(25,218
)
 
-
 
Deferred tax asset valuation allowance
   
(13,917,226
)
 
(10,923,448
)
Net deferred tax asset (liability)
 
$
-
 
$
-
 
 
At December 31, 2007, the Company has net operating loss carryforwards of approximately $32,822,648, which expire in the years 2008 through 2027. The net change in the allowance account was an increase of $2,993,778 for the year ended December 31, 2007.
 
In accordance with SFAS No. 109, the accounting for the tax benefits of acquired deductible temporary differences and NOL carryforwards, which are not recognized at the acquisition date because a valuation allowance is established and which are recognized subsequent to the acquisition, will be applied first to reduce to zero any goodwill and other non-current intangible assets related to the acquisition. Any remaining benefits would be recognized as a reduction of income tax expense. As of December 31, 2007, approximately $1,100,000 of deferred tax assets with a valuation allowance relates to our newly consolidated, majority owned subsidiary, the future benefits of which will be applied first to reduce to zero any goodwill and other non-current intangible assets related to the acquisition, prior to reducing our income tax expense.
 
F-23

 
12. CAPITAL STOCK
 
Common Stock
 
The Company has authorized 75,000,000 shares of its common stock, $0.01 par value. The Company had issued and outstanding 41,699,681 and 37,378,080 shares of its common stock at December 31, 2007 and 2006, respectively.
 
In the third quarter of 2007, QuantRx initiated a limited warrant exercise inducement targeting certain large warrant holders. The inducement was a reduction in the exercise price from $1.50 to $0.75 to a limited number of accredited investors holding warrants acquired in conjunction with prior common stock purchases. As a result of this inducement, 751,001 common stock warrants were exercised and exchanged for 751,001 shares of our common stock, $0.01 par value, for aggregate gross proceeds of $563,251. In connection with the exercise of these warrants, QuantRx paid cash commissions to Legend Merchant, Inc. of $16,429.
 
In the third quarter of 2007, 38,100 common stock warrants were exercised and exchanged for 38,100 shares of our common stock, $0.01 par value, resulting in proceeds to the Company of $20,955. The exercise price for these warrants was $0.55.
 
On March 1, 2007, QuantRx completed a private placement of 3,532,500 shares of common stock and warrants with a five-year term valued at $1,243,087 to purchase an aggregate of 1,059,750 shares of common stock at $1.50 per share to accredited investors for gross proceeds of $3,532,500 in cash. The Company issued warrants with a seven-year term to purchase 194,250 shares of common stock at $1.00 per share valued at $277,778, and paid cash commissions of $155,400 in connection with the private placement to Legend Merchant Inc., and an additional $2,104 for related legal services.
 
On December 6, 2006, QuantRx completed a private placement of 2,040,000 shares of common stock and warrants to purchase an aggregate of 612,000 shares of common stock at $1.50 per share to accredited investors for gross proceeds of $2,040,000 in cash. The Company issued warrants to purchase 131,500 shares of common stock at $1.00 per share valued at $188,045 and paid cash commissions of $105,200 in connection with the private placement to Legend Merchant Inc. Additionally, fees of $17,167 were paid to a law firm to act as escrow agent for this transaction. In conjunction with this transaction, QuantRx converted $3,980,000 in convertible debt and related accrued interest of $286,874 into 4,693,542 common shares pursuant to the terms of the convertible debt. Upon conversion, the former debt holders also received warrants to purchase an aggregate of 1,408,037 shares of common stock at $1.50 per share.
 
In the third quarter of 2006, QuantRx issued 52,244 common shares upon conversion of $50,000 convertible debt and related accrued interest of $2,244. The conversion was made at the holder’s option pursuant to the terms of the convertible note.
 
In the second quarter of 2006, 50,000 common shares were issued to CEOcast, Inc., an investor relations consulting firm, pursuant to a one-year consulting agreement. The common shares were valued at $1.30 per share, the closing price on the date of issuance, for a total valuation of $65,000. In the fourth quarter, the agreement with CEOcast was cancelled, resulting in the return and cancellation of 35,000 common shares valued at $45,500. The fair value of the remaining 15,000 common shares was $19,500, all of which was expensed in 2006 pursuant to the revised agreement.
 
F-24

 
In the second quarter of 2006, execution of a settlement of a loan in the amount of $20,000 resulted in the issuance of 40,000 shares of common stock in complete payment of the loan. The shares were issued at $0.50 per share, which was the market value of the shares at the time the negotiation of the terms of the settlement had been concluded.
 
In the first quarter of 2006, 85,800 common stock warrants were exercised and exchanged for 85,800 shares of common stock, $0.01 par value, resulting in proceeds to the Company of $57,430. The exercise prices ranged from $0.20 to $0.85.
 
Effective February 13, 2006, holders of all outstanding shares of the Series A convertible preferred stock of QuantRx exercised their rights under the terms of the Series A preferred stock to convert all of their outstanding shares of Series A preferred stock into shares of QuantRx’s common stock. Each share of Series A preferred stock was converted into 1.5 shares of QuantRx common stock, resulting in the issuance by QuantRx of 12,211,721 common shares. As of December 31, 2006, there are no shares of Series A preferred stock outstanding.
 
Preferred Stock
 
The Company has authorized 25,000,000 shares of preferred stock, of which 9,750,000 are designated Series A convertible preferred stock, $0.01 par value, with a conversion ratio of 1.5 common shares for each share of Series A preferred stock. The remaining 15,250,000 authorized preferred shares have not yet been designated by the Company. The Company had no issued and outstanding shares of its Series A convertible preferred stock at December 31, 2007 and 2006.
 
13. STOCK PURCHASE WARRANTS
 
Common Stock Warrants
 
On October 16, 2007, QuantRx completed a private placement of 10% senior secured convertible promissory notes and warrants to purchase shares of QuantRx' common stock. In connection with the private placement, QuantRx issued warrants to purchase 250,000 shares of QuantRx' common stock at an exercise price of $0.75 (relative fair value of $134,454). The warrants entitle the holder thereof to purchase the number of shares of QuantRx' common stock equal to 20% of the shares underlying such holder's note on the original issue date. The notes and the warrants were offered only to certain private accredited investors. In association with the issuance of these convertible notes, QuantRx issued warrants for services to purchase 100,000 shares of common stock at $0.75 per share valued at $65,000.
 
Throughout 2007, the Company issued an aggregate of 14,000 common stock warrants with five-year terms and exercise prices equal to the market price on the dates of grant (varying between $0.61 to $1.15). These warrants were in consideration of business development consulting services. The fair value of these warrants was calculated to be $11,160, which was expensed in 2007.
 
In the third quarter 2007, QuantRx initiated a limited warrant exercise inducement targeting certain large warrant holders. The inducement was a reduction in the exercise price from $1.50 to $0.75 to a limited number of accredited investors holding warrants acquired in conjunction with prior common stock purchases. As a result of this inducement, 751,001 common stock warrants were exercised and exchanged for 751,001 shares of our common stock, $0.01 par value, for aggregate net proceeds of $546,822.
 
F-25

 
 
In August 2007, 38,100 common stock warrants were exercised and exchanged for 38,100 shares of our common stock, $0.01 par value, resulting in proceeds to the Company of $20,955. The exercise price for these warrants was $0.55. 
 
On April 30, 2007, the Company issued a warrant to in consideration of financial advisory and public relations consulting services performed through April 30, 2007. The warrant has a term of five years and represents the right to purchase 30,000 shares of common stock at an exercise price of $1.20. The fair value of this warrant was calculated to be $31,800 and was expensed in 2007.
 
On April 16, 2007, the Company issued a warrant in consideration of a financial advisory and investor relations consulting services agreement with an initial one year term. The original agreement was modified June 20, 2007. The original warrant had a term of five years and represented the right to purchase 350,000 shares of common stock at an exercise price of $1.35 and vested ratably each month over the initial one year term. The fair value of the original warrant was calculated to be $420,000. On June 20, 2007, the agreement was modified and the original warrant was cancelled. The warrant issued upon modification of the agreement has the same terms as the originally issued warrant other than it represents the right to purchase 150,000 shares of common stock at an exercise price of $0.95, which was the closing price on the modification date. The fair value of the modified warrant was calculated to be $126,000 on the modification date, and shall be remeasured during the vesting term as required. Consulting expense related to the issuance of these warrants was $114,062 in 2007, and includes $28,000 expensed in the second quarter related to the cancelled warrants.
 
On April 16, 2007, the Company issued common stock warrants with a five year term to purchase 50,000 shares of common stock at an exercise price of $1.35. The warrants were issued as payment for technical advisory services related to medical diagnostics. The fair value of these warrants was calculated to be $60,000, and will be expensed over the initial year of the agreement. Consulting expense related to the issuance of these warrants was $42,623 in 2007.
 
In the first quarter of 2007, QuantRx issued 200,000 common stock warrants with a five-year term to purchase 200,000 shares of common stock at an exercise price of $1.50. The warrants were issued pursuant to a financial advisory services agreement, and the fair value of $250,000 for these warrants was expensed over the service term of four months.
 
On March 1, 2007, QuantRx issued warrants with a five-year term valued at $1,243,087 to purchase an aggregate of 1,059,750 shares of common stock at $1.50 per share to accredited investors in conjunction with a private placement of common stock. The Company issued warrants with a seven-year term to purchase 194,250 shares of common stock at $1.00 per share valued at $277,778 in connection with the private placement to Legend Merchant Inc.
 
On December 6, 2006, QuantRx completed a private placement of 2,040,000 shares of common stock and warrants valued at $771,120 to purchase an aggregate of 612,000 shares of common stock at $1.50 per share to accredited investors for gross proceeds of $2,040,000 in cash. The Company issued warrants to purchase 131,500 shares of common stock at $1.00 per share valued at $188,045. In conjunction with this transaction, QuantRx converted $3,980,000 in convertible debt and related accrued interest of $286,874 into 4,693,542 common shares pursuant to the terms of the convertible debt. Upon conversion, the former debt holders also received warrants to purchase an aggregate of 1,408,037 shares of common stock at $1.50 per share, valued at $1,774,127. The valuation placed on the warrants issued for services was deemed by the Company to be additional costs related to the issuance of common stock. The costs were therefore charged against additional paid-in capital and resulted in a memorandum entry only.
 
F-26

 
 
In the second quarter of 2006, the Company issued 150,000 common stock warrants with a five-year term to purchase 150,000 shares of common stock at an exercise price of $2.00. The warrants were issued pursuant to a one-year consulting agreement, and the fair value of $219,000 for these warrants will be expensed over the one-year term of the agreement.
 
In the second quarter of 2006, the Company issued 68,500 common stock warrants with a five-year term to purchase 68,500 shares of common stock at an exercise price of $2.00. The warrants were issued as payment for purchased research and development data, and the fair value of $100,010 for these warrants was recorded as research and development expense in the second quarter of 2006.
 
In association with the issuance of convertible promissory notes in 2006, QuantRx issued warrants for services to purchase 90,560 shares of common stock at $1.50 per share valued at $143,049 and warrants to investors to purchase 723,250 shares of common stock at $1.50 valued at $1,131,663.
 
In the first quarter of 2006 warrants to purchase 180,000 shares Series A preferred stock were submitted and exchanged for warrants to purchase 180,000 shares of common stock, with the same terms as the original warrants.
 
In the first quarter of 2006, 85,800 common stock warrants were exercised and exchanged for 85,800 shares of common stock, $0.01 par value, resulting in proceeds to the Company of $57,430. The exercise prices ranged from $0.20 to $0.85.
 
The following is a summary of all common stock warrant activity during the two years ended December 31, 2007:
 
   
Number of Shares Under Warrants
 
Exercise Price Per Share
 
Weighted Average Exercise Price
 
Warrants issued and exercisable at December 31, 2005
   
2,663,937
 
$
0.01 - 2.00
 
$
0.80
 
Warrants granted
   
3,363,847
 
$
1.00 - 4.25
 
$
1.57
 
Warrants expired
   
(87,500
)
$
0.01 - 1.50
 
$
1.30
 
Warrants exercised
   
(85,800
)
$
0.20 - 0.85
 
$
0.67
 
Warrants issued and exercisable at December 31, 2006
   
5,854,484
 
$
0.50 - 4.25
 
$
1.23
 
Warrants granted
   
2,048,000
 
$
0.61 - 1.50
 
$
1.24
 
Warrants expired
   
-
   
-
   
-
 
Warrants exercised
   
(789,101
)
$
0.55 - 0.75
 
$
0.74
 
Warrants issued and exercisable at December 31, 2007
   
7,113,383
 
$
0.50 - 4.25
 
$
1.20
 
 
F-27

 
The following represents additional information related to common stock warrants outstanding and exercisable at December 31, 2007:
 
Exercise Price
 
Number of Shares Under
Warrants
 
Weighted Average Remaining
Contract Life in Years
 
Weighted Average
 Exercise Price
 
$ 0.50
   
956,873
   
3.58
 
$
0.50
 
$ 0.55
   
179,098
   
4.41
 
$
0.55
 
$ 0.61
   
4,000
   
4.88
 
$
0.61
 
$ 0.75
   
377,000
   
3.46
 
$
0.75
 
$ 0.85
   
1,040,196
   
2.41
 
$
0.85
 
$ 0.87
   
2,000
   
4.68
 
$
0.87
 
$ 0.95
   
150,000
   
4.30
 
$
0.95
 
$ 1.00
   
325,750
   
6.10
 
$
1.00
 
$ 1.10
   
100,000
   
4.79
 
$
1.10
 
$ 1.15
   
6,000
   
4.42
 
$
1.15
 
$ 1.20
   
30,000
   
4.33
 
$
1.20
 
$ 1.25
   
250,000
   
4.79
 
$
1.25
 
$ 1.35
   
50,000
   
4.30
 
$
1.35
 
$ 1.50
   
3,143,966
   
2.45
 
$
1.50
 
$ 1.92
   
130,000
   
0.67
 
$
1.92
 
$ 2.00
   
318,500
   
3.01
 
$
2.00
 
$ 4.25
   
50,000
   
0.67
 
$
4.25
 
     
7,113,383
   
2.82
 
$
1.20
 
 
The Company used the Black-Scholes option price calculation to value the warrants granted in 2007 and 2006 using the following assumptions: risk-free rate of 5.77% and 4.93%; volatility of 1.35 and 1.70; actual term and exercise price of warrants granted.
 
Preferred Stock Warrants
 
Effective February 13, 2006, holders of all outstanding shares of the Series A convertible preferred stock of QuantRx exercised their rights under the terms of the Series A preferred stock to convert all of their outstanding shares of Series A preferred stock into shares of QuantRx’s common stock. In connection with this transaction, warrants to purchase 180,000 shares Series A preferred stock were submitted and exchanged for warrants to purchase 180,000 shares of common stock, with the same terms as the original warrants.
 
The following is a summary of all preferred stock warrant activity during the two years ended December 31, 2007:
 
   
Number of
Shares
 
Exercise Price Per Share
 
Weighted Average Exercise Price
 
Warrants issued and exercisable at 12/31/05
   
180,000
 
$
1.92 - $ 4.25
 
$
2.57
 
Warrants granted
   
-
   
-
   
-
 
Warrants expired
   
-
   
-
   
-
 
Warrants exercised
   
-
   
-
   
-
 
Warrants converted
   
(180,000
)
$
1.92 - $ 4.25
 
$
2.57
 
Warrants issued and exercisable at 12/31/06 and 12/31/07
   
-
   
-
   
-
 
 
F-28

 
14. COMMON STOCK OPTIONS
 
In 2007, the Company adopted the 2007 Incentive and Non-Qualified Stock Option Plan (hereinafter “the Plan”), which replaced the 1997 Incentive and Non-Qualified Stock Option Plan, as amended in 2001, and under which 8,000,000 shares of common stock are reserved for issuance under qualified options, nonqualified options, stock appreciation rights and other awards as set forth in the Plan.
 
Under the Plan, qualified options are available for issuance to employees of the Company and non-qualified options are available for issuance to consultants and advisors. The Plan provides that the exercise price of a qualified option cannot be less than the fair market value on the date of grant and the exercise price of a nonqualified option must be determined on the date of grant. Options granted under the Plan generally vest three to five years from the date of grant and generally expire ten years from the date of grant.
 
In the fourth quarter of 2007, 6,250 non-qualified common stock options were granted to a member of the board of directors and issued from the Company’s Incentive and Non-Qualified Stock Option Plan. The options were issued with an exercise price of $0.69, have a term of five years and vested immediately. The fair value of these options is $3,813.
 
In the fourth quarter of 2007, a total of 413,000 qualified common stock options were granted to employees and issued from the Company’s Incentive and Non-Qualified Stock Option Plan. The options were issued with an exercise price of $0.85, and have a term of ten years. The options vest monthly over one year. The fair value of these options is $342,790.
 
In the fourth quarter of 2006, 12,500 non-qualified common stock options were granted to two directors and issued from the Company’s Incentive and Non-Qualified Stock Option Plan. The options were issued with an exercise price of $1.17, have a term of five years and vested immediately. The fair value of these options is $13,876.
 
In the third quarter of 2006, 75,000 qualified common stock options were granted to an executive officer and issued from the Company’s Incentive and Non-Qualified Stock Option Plan. The options were issued with an exercise price of $1.15, have a term of ten years and vest January 1, 2007. The fair value of these options is $85,575.  
 
In the second quarter of 2006, a total of 225,000 qualified common stock options were granted to executive officers and issued from the Company’s Incentive and Non-Qualified Stock Option Plan. The options were issued with an exercise price of $1.60, and have a term of ten years. Of the options granted in the second quarter, 25,000 vested immediately, with the remaining 200,000 vesting when certain sales milestones have been reached. The Company estimates that these milestones will be reached over an expected service term of five years. The fair value of these options is $357,750.
 
Pursuant to SFAS No. 123(R), the fair value amounts will be accrued to compensation expense over the expected service terms, not to exceed the vesting period. The accrued compensation expense related to QuantRx’s options for the years ended December 31, 2007 and 2006 is $219,564 and $253,355, respectively.
 
F-29

 
The following is a summary of all common stock option activity during the two years ended December 31, 2007:
 
   
Shares Under Options Outstanding
 
Weighted Average Exercise Price
 
Outstanding at December 31, 2005
   
1,060,000
 
$
0.53
 
Options granted
   
312,500
 
$
1.46
 
Options forfeited
   
-
   
-
 
Options exercised
   
-
   
-
 
Outstanding at December 31, 2006
   
1,372,500
 
$
0.74
 
Options granted
   
419,250
 
$
0.85
 
Options forfeited
   
-
   
-
 
Options exercised
   
-
   
-
 
Outstanding at December 31, 2007
   
1,791,750
 
$
0.77
 

 
   
Options Exercisable
 
Weighted Average Exercise Price Per Share
 
Exercisable at December 31, 2006
   
801,045
 
$
0.58
 
Exercisable at December 31, 2007
   
1,207,872
 
$
0.63
 
 
The following represents additional information related to common stock options outstanding and exercisable at December 31, 2007:
 
   
Outstanding
 
Exercisable
 
Exercise Price
 
Number of Shares
 
Weighted Average Remaining Contract Life in Years
 
Weighted Average Exercise Price
 
Number of Shares
 
Weighted Average Exercise Price
 
$ 0.50
   
1,000,000
   
7.34
 
$
0.50
   
925,872
 
$
0.50
 
$ 0.69
   
6,250
   
5.00
 
$
0.69
   
6,250
 
$
0.69
 
$ 0.85
   
413,000
   
9.78
 
$
0.85
   
103,250
 
$
0.85
 
$ 1.00
   
60,000
   
2.18
 
$
1.00
   
60,000
 
$
1.00
 
$ 1.15
   
75,000
   
8.57
 
$
1.15
   
75,000
 
$
1.15
 
$ 1.17
   
12,500
   
4.00
 
$
1.17
   
12,500
 
$
1.17
 
$ 1.60
   
225,000
   
8.26
 
$
1.60
   
25,000
 
$
1.60
 
     
1,791,750
   
7.87
 
$
0.77
   
1,207,872
 
$
0.63
 
 

F-30

 
A summary of the status of the Company’s nonvested stock options as of December 31, 2007 and changes during the year ended December 31, 2007 is presented below:
 
Nonvested Stock Options
 
Shares
 
Weighted Average Grant Date Fair Value
 
Nonvested at December 31, 2006
   
571,455
 
$
0.86
 
Options granted
   
419,250
 
$
0.83
 
Options vested
   
(406,827
)
 
($ 0.59
)
Options forfeited
   
-
   
-
 
Nonvested at December 31, 2007
   
583,878
 
$
1.02
 
 
As of December 31, 2007, there was approximately $485,949 of unrecognized compensation cost related to nonvested options. Weighted average period of nonvested stock options was 8.9 years as of December 31, 2007.
 
The Company used the Black-Scholes option price calculation to value the warrants granted in 2007 and 2006 using the following assumptions: risk-free rate of 5.77% and 4.93%; volatility of 1.35 and 1.70; actual term and exercise price of warrants granted.
 
15. RELATED PARTY TRANSACTIONS
 
In October 2007, in connection with a debt financing, QuantRx issued warrants with a five-year term valued at $65,000 to purchase an aggregate of 100,000 shares of common stock at $1.10 per share to Burnham Hill Partners, of which a beneficial owner of more than 5% of QuantRx common stock is a managing member. Burnham Hill Partners was the placement agent for the debt financing. Additionally, cash commissions of $70,000 are due to Burnham Hill Partners for its role as placement agent in the transaction.
 
In April 2007, our subsidiary FluoroPharma, Inc. advanced $100,000 to one of its executive officers through a 6% promissory note due December 31, 2007. The Company recognized interest of $2,959 on this note. The note and accrued interest were paid in full in October 2007.
 
On March 9, 2007, the Company issued 200,000 common stock warrants with a five year term to purchase 200,000 shares of common stock at an exercise price of $1.50. The warrants were issued as payment pursuant to a financial advisory services agreement with Burnham Hill Partners, of which a beneficial owner of more than 5% of QuantRx common stock is a managing member. The fair value of these warrants was calculated to be $250,000 and was expensed over the four month service term. Additionally, cash compensation of $200,000 was paid pursuant to the terms of the agreement and was also expensed over the four month service term.
 
A member of the Company’s board of directors serves as a consultant to the Company on various business, strategic, and technical issues. His current contract expires May 31, 2008. Fees paid and expensed under these agreements for these services by the Company during the years ended December 31, 2007 and 2006 were $48,000, respectively. In addition to the contract fees paid, reimbursable expenses totaling $10,000 and $10,000 were paid in 2007 and 2006, respectively.
 
The Company had a temporary arrangement in which it leased office space from Trident Group, LLC, of which the current chief executive officer was a principal. In addition to a monthly rental payment for office space, the Company reimbursed Trident for related office expenses. The Company terminated the agreement in the third quarter of 2006. The total amount paid and expensed by the Company under this arrangement was $10,040 in 2006.
 
F-31

 
16. SUBSEQUENT EVENTS
 
2008 Convertible Promissory Notes
 
In the first quarter of 2008, QuantRx issued 10% senior secured convertible promissory notes and warrants to purchase 250,000 shares of common stock for aggregate gross proceeds of $1,000,000. Debt financing costs of $70,000 were incurred and warrants with a five year term to purchase 100,000 shares of common stock and an exercise price of $1.10 were issued to the placement agent. Proceeds of the financing will be used for general corporate purposes. The notes and the warrants were offered only to certain private accredited investors.
 
F-32

EX-21.1 LIST OF SUBSIDIARIES
 
Subsidiaries of QuantRx Biomedical Corporation
As of December 31, 2007
 
 
 
Organized
Under
Laws of:
 
Percentage
of Voting
Power
 
           
FluoroPharma, Inc.
   
Delaware
   
57.78
%
 

EXHIBIT 31.1

CERTIFICATION

I, Walter W. Witoshkin, certify that:

 
1.
I have reviewed this Form 10-KSB of QuantRx Biomedical Corporation;

 
2.
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 
3.
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 
4.
The registrant’s other certifying officer(s) and I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)):

 
a.
Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 
b.
Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

 
c.
Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 
5.
The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

 
a.
All significant deficiencies and material weaknesses in reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

 
b.
Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 
6.
I have indicated in this report whether or not there were significant changes in internal controls or in other factors that could significantly affect internal controls or in other factors that could significantly affect internal controls subsequent to the date of our most recent evaluation, including any corrective actions with regard to significant deficiencies and material weaknesses.
     
 
 
 
 
 
 
Date: March 31, 2008 /s/ Walter W. Witoshkin
 
Walter W. Witoshkin
Chairman & CEO
 
 
 

 
EXHIBIT 31.2

CERTIFICATION

I, Sasha Afanassiev, certify that:

 
1.
I have reviewed this Form 10-KSB of QuantRx Biomedical Corporation;

 
2.
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 
3.
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 
4.
The registrant’s other certifying officer(s) and I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)):

 
a.
Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

 
b.
Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

 
c.
Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 
5.
The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

 
a.
All significant deficiencies and material weaknesses in reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

 
b.
Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

 
6.
I have indicated in this report whether or not there were significant changes in internal controls or in other factors that could significantly affect internal controls or in other factors that could significantly affect internal controls subsequent to the date of our most recent evaluation, including any corrective actions with regard to significant deficiencies and material weaknesses.
 
Date: March 31, 2008    
     
  /s/ Sasha Afanassiev
 
Sasha Afanassiev
CFO, Treasurer & V.P. of Finance
 
 

EXHIBIT 32.1

CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report of QuantRx Biomedical Corporation (the “Company”) on Form 10-KSB for the period ending December 31, 2007 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Walter W. Witoshkin, Chairman and CEO of the Company, certify, pursuant to 18 U.S.C. ss.1350, as adopted pursuant to ss.906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

 
1.
The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

 
2.
The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
     
 
 
 
 
 
 
/s/ Walter W. Witoshkin
 
Walter W. Witoshkin
Chairman & CEO
   
Date: March 31, 2008  


EXHIBIT 32.2

CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report of QuantRx Biomedical Corporation (the “Company”) on Form 10-KSB for the period ending December 31, 2007 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Sasha Afanassiev, Treasurer and CFO of the Company, certify, pursuant to 18 U.S.C. ss.1350, as adopted pursuant to ss.906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

 
1.
The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

 
2.
The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
     
 
/s/ Sasha Afanassiev
 
Sasha Afanassiev
CFO, Treasurer & V.P. of Finance
 
Date: March 31, 2008
 

 
 

 
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