X0304 4 2012-03-16 0 0000820237 GEN PROBE INC GPRO 0001205465 HULL CARL GEN-PROBE INCORPORATED 10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 1 1 0 0 Chairman and CEO Common Stock 2012-03-16 4 M 0 6354 43.72 A 53321 D Common Stock 2012-03-16 4 M 0 5729 47.42 A 59050 D Common Stock 2012-03-16 4 S 0 12083 66.56 D 46967 D Stock Option (Right to Buy) 43.72 2012-03-16 4 M 0 6354 0 D 2016-05-18 Common Stock 6354 19480 D Stock Option (Right to Buy) 47.42 2012-03-16 4 M 0 5729 0 D 2014-03-01 Common Stock 5729 69271 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person in December 2011. This transaction was executed in multiple trades at prices ranging from $66.34 to $66.80. The price reported above reflects the weighted average sale price for these transactions. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the reported transactions were effected. 25% of the shares subject to the stock option vested and became exercisable on May 18, 2010 and the remaining shares subject to the stock option vest and become exercisable in equal monthly installments over the following three years. The shares subject to the stock option vested and became fully exercisable as of March 1, 2011. /s/ R. William Bowen, Attorney-in-Fact 2012-03-20