X0304 4 2012-01-17 0 0000820237 GEN PROBE INC GPRO 0001205465 HULL CARL GEN-PROBE INCORPORATED 10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 1 1 0 0 Chairman and CEO Common Stock 2012-01-17 4 M 0 17083 43.72 A 60787 D Common Stock 2012-01-17 4 S 0 17083 60.859 D 43704 D Stock Option (Right to Buy) 43.72 2012-01-17 4 M 0 17083 0 D 2016-05-18 Common Stock 17083 37917 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person in December 2011. This transaction was executed in multiple trades at prices ranging from $60.52 to $61.11. The price reported above reflects the weighted average sale price for these transactions. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the reported transactions were effected. The amount reported includes an aggregate of 75 shares of common stock acquired under the Gen-Probe Incorporated Employee Stock Purchase Plan since the reporting person last filed a Form 4 with the Securities and Exchange Commission. 25% of the shares subject to the stock option vested and became exercisable on May 18, 2010 and the remaining shares subject to the stock option vest and become exercisable in equal monthly installments over the following three years. /s/ R. William Bowen, Attorney-in-Fact 2012-01-19