X0202 4 2005-01-03 0 0000820237 GEN PROBE INC GPRO 0001230048 BOWEN R WILLIAM GEN-PROBE INCORPORATED 10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 0 1 0 0 VP, General Counsel Common Stock 2005-01-03 4 M 0 7898 13.655 A 7898 D Common Stock 2005-01-03 4 M 0 9102 12.29 A 17000 D Common Stock 2005-01-03 4 S 0 1300 45.40 D 15700 D Common Stock 2005-01-03 4 S 0 200 45.27 D 15500 D Common Stock 2005-01-03 4 S 0 420 45.26 D 15080 D Common Stock 2005-01-03 4 S 0 606 45.25 D 14474 D Common Stock 2005-01-03 4 S 0 200 45.22 D 14274 D Common Stock 2005-01-03 4 S 0 4557 45.21 D 9717 D Common Stock 2005-01-03 4 S 0 963 45.20 D 8754 D Common Stock 2005-01-03 4 S 0 100 45.01 D 8654 D Common Stock 2005-01-03 4 S 0 4400 45.00 D 4254 D Common Stock 2005-01-03 4 S 0 800 44.84 D 3454 D Common Stock 2005-01-03 4 S 0 1100 44.81 D 2354 D Common Stock 2005-01-03 4 S 0 200 44.80 D 2154 D Common Stock 2005-01-03 4 S 0 300 44.54 D 1854 D Common Stock 2005-01-03 4 S 0 1500 44.53 D 354 D Common Stock 2005-01-03 4 S 0 354 44.52 D 0 D Employee Stock Option (Right to Buy) 13.655 2005-01-03 4 M 0 7898 0 D 2010-08-17 Common Stock 7898 4131 D Employee Stock Option (Right to Buy) 12.29 2005-01-03 4 M 0 2461 0 D 2011-09-01 Common Stock 2461 2700 D Employee Stock Option (Right to Buy) 12.29 2005-01-03 4 M 0 6641 0 D 2012-06-01 Common Stock 6641 13729 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2004. Option vests as follows: 25% vest on 8/17/01; 1/48th vesting monthly following three years Option vests as follows: 25% vest on 9/1/02; 1/48th vesting monthly following three years Option vests as follows: 25% vest on 6/1/03; 1/48th vesting monthly following three years /s/ R. William Bowen 2005-01-05