X0202 4 2003-08-29 0 0000820237 GEN PROBE INC GPRO 0001230318 CONWAY NIALL M 10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 0 1 0 0 Executive Vice President Common Stock 2004-03-16 4 M 0 3000 12.29 A 4100 D Common Stock 2003-08-29 4 M 0 614 16.91 A 4714 D Common Stock 2004-02-27 4 M 0 789 26.92 A 5503 D Common Stock 2004-03-16 4 S 0 3000 34.24 D 2503 D Common Stock 2004-06-17 4 S 0 400 42.70 D 5353 D Common Stock 2004-06-17 4 S 0 2000 42.69 D 3353 D Common Stock 2004-06-17 4 S 0 100 42.68 D 3253 D Common Stock 2004-06-17 4 S 0 100 42.62 D 3153 D Common Stock 2004-06-17 4 S 0 100 42.60 D 3053 D Common Stock 2004-06-17 4 S 0 100 42.58 D 2953 D Common Stock 2004-06-17 4 S 0 200 42.57 D 2753 D Common Stock 2004-06-17 4 S 0 100 42.53 D 2653 D Common Stock 2004-06-17 4 S 0 100 42.51 D 2553 D Common Stock 2004-06-17 4 S 0 50 42.50 D 2503 D Common Stock 260 I By Wife Employee Stock Option (Right to Buy) 12.29 2004-03-16 4 M 0 3000 0 D 2012-06-01 Common Stock 3000 47848 D Employee Stock Option (Right to Buy) 12.29 2004-06-17 4 M 0 3250 0 D 2012-06-01 Common Stock 3250 44598 D Shares acquired under the Gen-Probe Incorporated Employee Stock Purchase Plan. The number of shares remaining under this stock option following the last exercise was incorrectly reported on the last Form 4 filed for the reporting person, and has been adjusted herein to reflect the accurate balance remaining under this stock option. Option vests as follows: 25% vest on 6/1/03; 1/48th vesting monthly following three years. /s/ R. William Bowen, Attorney-in-Fact 2004-06-21