X0201 4 2003-01-05 0 0000820237 GEN PROBE INC GPRO 0001230054 NORDHOFF HENRY L GEN-PROBE INCORPORATED 10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 1 1 0 0 President & CEO Common Stock 2004-01-05 4 M 0 4000 12.29 A 8086 D Common Stock 2004-01-05 4 S 0 4000 35.01 D 4086 D Employee Stock Option (Right to Buy) 12.29 2004-01-05 4 M 0 4000 0 D 2012-06-01 Common Stock 4000 480673 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 15, 2003. Option vests as follows: 25% vest on 6/1/03; 1/48th vesting monthly following three years. /s/ R. William Bowen, Attorney-in-Fact 2004-01-06