X0201 4 2003-09-18 1 0000820237 GEN PROBE INC GPRO 0001230316 FREIBERG GLEN PAUL GEN-PROBE INCORPORATED 10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 0 0 0 1 Officer,VP,Reg. & Gov. Affairs Common Stock 2003-09-18 4 M 0 3500 27.31 A 3800 D Common Stock 2003-09-18 4 S 0 100 65.88 D 3700 D Common Stock 2003-09-18 4 S 0 1488 65.86 D 2212 D Common Stock 2003-09-18 4 S 0 100 65.82 D 2112 D Common Stock 2003-09-18 4 S 0 507 65.811 D 1605 D Common Stock 2003-09-18 4 S 0 1305 65.80 D 300 D Employee Stock Option (Right to Buy) 27.31 2003-09-19 4 M 0 3500 0 D 2010-08-17 Common Stock 3500 4213 D Option vests as follows: 25% on 8/17/01; 1/48th vesting monthly thereafter following three years. /s/ R. William Bowen, Attorney-in-Fact 2018-09-03