Summary of Significant Accounting Policies (Details 2) (USD $) In Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2011	Jun. 30, 2010	Jun. 30, 2011	Jun. 30, 2010
Stock-based compensation expense
Stock-based compensation	$ 6,823	$ 6,437	$ 12,859	$ 12,338
Cost of product sales [Member]
Stock-based compensation expense
Stock-based compensation	794	1,006	1,582	1,870
Research and development [Member]
Stock-based compensation expense
Stock-based compensation	2,061	1,851	3,853	3,530
Marketing and sales [Member]
Stock-based compensation expense
Stock-based compensation	734	836	1,346	1,637
General and administrative [Member]
Stock-based compensation expense
Stock-based compensation	$ 3,234	$ 2,744	$ 6,078	$ 5,301