Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Net product sales	$ 86,346	$ 88,638	$ 145,968
Operating expenses:
Cost of product sales	46,021	36,189	61,619
Research and development	130,821	174,533	167,382
General and administrative	40,153	42,226	37,897
Sales and marketing	87,179	63,853	89,764
Total operating expenses	304,174	316,801	356,662
Loss from operations	(217,828)	(228,163)	(210,694)
Other income (expense), net:
Interest income	433	3,633	7,259
Interest expense	(2,410)	(1,901)	(1,472)
Other income (expense)	(878)	(847)	158
Total other income (expense), net	(2,855)	885	5,945
Net loss	(220,683)	(227,278)	(204,749)
Other comprehensive income (loss):
Unrealized gains (losses) on short-term investments	(263)	172	172
Comprehensive loss	$ (220,946)	$ (227,106)	$ (204,577)
Basic and diluted net loss per share	$ (2.24)	$ (2.50)	$ (2.50)
Shares used in computing basic and diluted net loss per share	98,471	90,774	81,779