Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 90,541	$ 105,138
Short-term investments	67,039	103,353
Accounts receivable, net	35,499	41,850
Inventory	48,382	41,905
Prepaid expenses and other current assets	12,962	21,950
Total current assets	254,423	314,196
Property and equipment, net	23,734	22,737
Right-of-use lease assets	9,829	16,277
Other assets	17,720	346
Total assets	305,706	353,556
Current liabilities:
Accounts payable	3,803	525
Accrued clinical and manufacturing liabilities	23,716	49,962
Accrued payroll and employee liabilities	15,263	13,597
Other accrued liabilities	25,859	28,369
Current lease liabilities	2,417	2,997
Convertible notes payable to related parties, net of discount		7,053
Total current liabilities	71,058	102,503
Non-current lease liabilities	7,996	14,561
Non-current convertible notes payable, net	149,082
Total liabilities	228,136	117,064
Commitments and contingencies (see Note 6)
Stockholders’ equity:
Preferred stock, $0.01 par value: 2,500 shares authorized; no shares issued or outstanding at December 31, 2021 and 2020
Common stock, $0.01 par value: 150,000 shares authorized; 102,005 and 91,310 shares issued and outstanding at December 31, 2021 and 2020, respectively	1,020	913
Additional paid-in capital	1,689,987	1,628,070
Accumulated other comprehensive income (loss)	(6)	257
Accumulated deficit	(1,613,431)	(1,392,748)
Total stockholders’ equity	77,570	236,492
Total liabilities and stockholders’ equity	$ 305,706	$ 353,556