Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenues:
Net product sales	$ 23,230	$ 19,965	$ 65,691	$ 68,033
Operating expenses:
Cost of product sales	11,351	7,170	35,080	26,797
Research and development	28,595	49,182	101,944	130,080
General and administrative	9,786	9,482	30,266	29,723
Sales and marketing	25,206	12,515	62,692	48,300
Total operating expenses	74,938	78,349	229,982	234,900
Loss from operations	(51,708)	(58,384)	(164,291)	(166,867)
Other income (expense)	(700)	156	(1,746)	1,870
Net loss	(52,408)	(58,228)	(166,037)	(164,997)
Other comprehensive income (loss):
Unrealized gains (losses) on short-term investments	(45)	(413)	(261)	455
Comprehensive loss	$ (52,453)	$ (58,641)	$ (166,298)	$ (164,542)
Basic and diluted net loss per share	$ (0.51)	$ (0.64)	$ (1.71)	$ (1.82)
Shares used in computing basic and diluted net loss per share	101,906	90,849	97,290	90,671