X0206 3 2023-06-06 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001314760 Forbes William P 4242 CAMPUS POINT COURT, SUITE 200 SAN DIEGO CA 92121 0 1 0 0 EVP, Chief Development Officer Common Stock 4000 D Employee Stock Option (Right to Buy) 1.11 2033-06-06 Common Stock 500000 D Restricted Stock Units 0.00 Common Stock 50000 D Employee Performance Stock Option (Right to Buy) 1.11 2033-06-06 Common Stock 700000 D The stock option vests and becomes exercisable with respect to 125,000 shares on the first anniversary of the date of grant, followed by 375,000 shares vesting ratably each month over the subsequent three years, such that 500,000 options will be fully vested on the four year anniversary of the date of grant. The restricted stock units vest in four equal annual installments beginning one year after the date of grant, subject to the Reporting Person's continued service to the Issuer through the vesting date. The stock option vests and becomes exercisable with respect to escalating portions of the option grant upon the Issuer's stock price reaching certain pre-established levels ranging from $4.50 to $9.00 per share, subject to the Reporting Person's continued service to the Issuer through the vesting date. /s/ Lisa Peraza Attorney-in-fact for William P. Forbes 2023-06-12