X0407 4 2023-05-22 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001363558 Collard Craig A 4242 CAMPUS POINT COURT, SUITE 200 SAN DIEGO CA 92121 1 1 0 0 Chief Executive Officer 0 Common Stock 2023-05-22 4 F 0 691 1.45 D 37188 D Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to the quarterly vesting of shares from the restricted stock grant made on February 22, 2023. /s/ Lisa Peraza Attorney-in-fact for Craig Collard 2023-05-24