X0206 3 2023-02-22 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001601692 KOTLER KEVIN 4242 CAMPUS POINT COURT, SUITE 200 SAN DIEGO CA 92121 1 0 0 0 Common Stock 37879 D Common Stock 540000 I By Broadfin Holdings LLC Stock Option (Right to Buy) 2.70 2033-02-22 Common Stock 227272 D The shares were granted as restricted stock units which vest in 16 equal quarterly installments beginning one quarter after the date of grant (02/22/2023). The stock option vests and becomes exercisable in 48 equal monthly installments beginning one month after the date of grant (02/22/2023). /s/ Lisa Peraza Attorney-in-fact for Kevin Kotler 2023-03-02