X0306 4 2023-01-18 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001828266 Peraza Lisa 4242 CAMPUS POINT COURT SUITE 200 SAN DIEGO CA 92121 0 1 0 0 VP, Chief Accounting Officer Performance Stock Units 0.00 2023-01-18 4 A 0 42631 0.00 A Common Stock 42631 42631 D On July 25, 2022, the Compensation Committee of the Issuer (the "Committee") granted the Reporting Person Performance Stock Units ("PSUs"), the vesting of which was subject to the achievement of certain corporate performance goals and time-based vesting. On January 18, 2023, the Committee determined that certain performance goals of the PSUs had been achieved. The PSUs are further subject to a time-based vesting schedule. The PSUs will vest in full on the first anniversary of the grant date subject to continued employment through such date. Upon vesting and settlement of the PSUs, the Reporting Person will receive a number of shares of common stock of the Issuer equal to the number of PSUs that have vested. /s/ Lisa Peraza 2023-01-20