X0306 4 2022-04-13 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001602459 Szekeres David Leslie 4242 CAMPUS POINT COURT SUITE 200 SAN DIEGO CA 92121 0 1 0 0 EVP, Chief Operating Officer Common Stock 2022-04-13 4 M 0 1250 A 9033 D Common Stock 2022-04-13 4 M 0 4564 A 13597 D Common Stock 2022-04-13 4 F 0 2012 6.07 D 11585 D Restricted Stock Units 2022-04-13 4 M 0 1250 0.00 D Common Stock 1250 12500 D Restricted Stock Units 2022-04-13 4 M 0 4564 0.00 D Common Stock 4564 46192 D Restricted stock units convert into common stock on a one-for-one basis. Represents the withholding by the Company of certain of the vested shares of restricted stock to satisfy the minimum statutory tax obligations applicable to such transactions. The restricted stock units vest in 16 equal quarterly installments beginning one quarter after the date of grant (10/13/2020). The restricted stock units vest quarterly with 33% of the shares vesting during the first year, 33% of the shares vesting during the second year, 22% of the shares vesting during the third year and the remaining 12% of the shares vesting during the fourth year, such that all shares will be fully vested on the four year anniversary of the date of grant (10/13/2021). /s/ Lisa Peraza Attorney-in-fact for David Szekeres 2022-04-15