X0306 4 2021-06-21 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001370348 Johnson Craig A 4242 CAMPUS POINT COURT SUITE 200 SAN DIEGO CA 92121 1 0 0 0 Common Stock 2021-06-21 4 S 0 250 15.2024 D 3340 D The sale of common stock reported in this Form 4 was effected pursuant to a Rule 10b5-1 plan dated as of March 3, 2021. The range of sales prices received was $14.89 to $15.42. Upon request by the SEC staff, the issuer, or any security holder of the issuer, full information will be provided regarding the number of shares purchased or sold at each separate price. /s/ Lisa Peraza Attorney-in-fact for Craig A. Johnson 2021-06-22