X0306 4 2019-10-04 0 0000818033 HERON THERAPEUTICS, INC. /DE/ HRTX 0001178579 TANG KEVIN C 4747 EXECUTIVE DRIVE SUITE 510 SAN DIEGO CA 92121 1 0 0 0 Common Stock 2019-10-04 4 P 0 285714 17.50 A 5799810 I By LP Common Stock 14347 I As Trustee Common Stock 6941 D The securities are held by Tang Capital Partners, LP. Kevin Tang is the sole manager of Tang Capital Management, LLC, which is the general partner of Tang Capital Partners, LP. The securities are held by Kevin Tang as custodian for his minor children, as Trustee of the Kevin C. Tang Family Trust, and as Trustee of the Tang Advisors, LLC Profit Sharing Plan. 2,147 of these securities are held by Kevin Tang's IRA. /s/ Kevin Tang 2019-10-07