Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) shares in Thousands, $ in Thousands	Total	Private Placement	Common Stock	Common Stock Private Placement	Additional Paid-In Capital	Additional Paid-In Capital Private Placement	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balance at Dec. 31, 2021	$ 77,570		$ 1,020		$ 1,689,987		$ (6)	$ (1,613,431)
Balance (in shares) at Dec. 31, 2021			102,005
Issuance of common stock under Employee Stock Purchase Plan	1,444		$ 4		1,440
Issuance of common stock under Employee Stock Purchase Plan (in shares)			407
Issuance of common stock under equity incentive plan	(1,530)		$ 6		(1,536)
Issuance of common stock under equity incentive plan (in shares)			614
Issuance of common stock in a private placement		$ 75,145		$ 161		$ 74,984
Issuance of common stock in a private placement (in shares)				16,129
Stock-based compensation expense	42,980				42,980
Net loss	(182,024)							(182,024)
Net unrealized gain (loss) on short-term investments	(13)						(13)
Comprehensive loss	(182,037)
Balance at Dec. 31, 2022	13,572		$ 1,191		1,807,855		(19)	(1,795,455)
Balance (in shares) at Dec. 31, 2022			119,155
Issuance of common stock under Employee Stock Purchase Plan	904		$ 7		897
Issuance of common stock under Employee Stock Purchase Plan (in shares)			717
Issuance of common stock under equity incentive plan	(903)		$ 11		(914)
Issuance of common stock under equity incentive plan (in shares)			1,130
Issuance of common stock in a private placement		$ 29,755		$ 208		$ 29,547
Issuance of common stock in a private placement (in shares)				20,735
Issuance of common stock on exercise of pre-funded warrants	1		$ 86		(85)
Issuance of common stock on exercise of pre-funded warrants (in shares)			8,548
Issuance of warrants in debt financing	371				371
Stock-based compensation expense	32,854				32,854
Net loss	(110,559)							(110,559)
Net unrealized gain (loss) on short-term investments	32						32
Comprehensive loss	(110,527)
Balance at Dec. 31, 2023	(33,973)		$ 1,503		1,870,525		13	(1,906,014)
Balance (in shares) at Dec. 31, 2023			150,285
Issuance of common stock under Employee Stock Purchase Plan	637		$ 6		631
Issuance of common stock under Employee Stock Purchase Plan (in shares)			640
Issuance of common stock under equity incentive plan	303		$ 12		291
Issuance of common stock under equity incentive plan (in shares)			1,203
Stock-based compensation expense	12,962				12,962
Net loss	(13,580)							(13,580)
Comprehensive loss	(13,580)
Balance at Dec. 31, 2024	$ (33,651)		$ 1,521		$ 1,884,409		$ 13	$ (1,919,594)
Balance (in shares) at Dec. 31, 2024			152,128