Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Revenues:
Net product sales	$ 107,672	$ 86,346
Operating expenses:
Cost of product sales	54,874	46,021
Research and development	107,506	130,821
General and administrative	37,437	40,153
Sales and marketing	82,513	87,179
Total operating expenses	282,330	304,174
Loss from operations	(174,658)	(217,828)
Other expense, net:
Interest income	1,638	433
Interest expense	(2,474)	(2,410)
Other income (expense)	(6,530)	(878)
Total other expense, net	(7,366)	(2,855)
Net loss	(182,024)	(220,683)
Other comprehensive loss:
Unrealized losses on short-term investments	(13)	(263)
Comprehensive loss	$ (182,037)	$ (220,946)
Basic net loss per share	$ (1.67)	$ (2.24)
Shares used in computing basic net loss per share	108,876	98,471
Diluted net loss per share	$ (1.67)	$ (2.24)
Shares used in computing diluted net loss per share	108,876	98,471