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Quarterly Results of Operations (Unaudited) (Tables)
 12 Months Ended
Dec. 31, 2015
Quarterly Financial Data [Abstract]  
Schedule of quarterly results of operations
2015
 
1Q
 
2Q
 
3Q3
 
4Q
 
Year
Total revenue
 
$
2,080.8

 
$
2,277.8

 
$
2,334.1

 
$
2,563.3

 
$
9,256.0

Gross profit1
 
1,951.2

 
2,153.3

 
2,202.7

 
2,433.8

 
8,741.0

Income tax provision
 
108.2

 
114.6

 
14.2

 
184.5

 
421.5

Net income (loss)
 
718.9

 
356.2

 
(34.1
)
 
561.0

 
1,602.0

Net income (loss) per share:2
 
 
 
 
 
 
 
 
 
 
Basic
 
$
0.90

 
$
0.45

 
$
(0.04
)
 
$
0.71

 
$
2.02

Diluted
 
$
0.86

 
$
0.43

 
$
(0.04
)
 
$
0.69

 
$
1.94

Weighted average shares:
 
 
 
 
 
 
 
 
 
 
Basic
 
798.9

 
793.0

 
791.1

 
785.8

 
792.2

Diluted
 
834.1

 
825.3

 
791.1

 
816.5

 
824.9

2014
 
1Q4
 
2Q
 
3Q
 
4Q
 
Year
Total revenue
 
$
1,730.0

 
$
1,872.7

 
$
1,982.2

 
$
2,085.5

 
$
7,670.4

Gross profit1
 
1,621.4

 
1,745.7

 
1,859.1

 
1,951.7

 
7,177.9

Income tax provision
 
52.6

 
109.0

 
69.0

 
96.9

 
327.5

Net income
 
279.7

 
597.8

 
508.5

 
613.9

 
1,999.9

Net income per share:2
 
 
 
 
 
 
 
 
 
 
Basic
 
$
0.34

 
$
0.75

 
$
0.64

 
$
0.77

 
$
2.49

Diluted
 
$
0.33

 
$
0.72

 
$
0.61

 
$
0.74

 
$
2.39

Weighted average shares:
 
 
 
 
 
 
 
 
 
 
Basic
 
811.5

 
799.6

 
799.6

 
800.2

 
802.7

Diluted
 
845.1

 
831.0

 
832.8

 
834.6

 
836.0

1 
Gross profit is computed by subtracting cost of goods sold (excluding amortization of acquired intangible assets) from net product sales.
2 
The sum of the quarters may not equal the full year due to rounding. In addition, quarterly and full year basic and diluted earnings per share are calculated separately.
3 
Net income for 2015 was a loss in the third quarter primarily due to costs related to collaborations and the acquisition of Receptos.
4 
Net income for 2014 was lower in the first quarter compared to each of the other three quarters primarily due to a higher level of expense related to research and development collaborations.