CONSOLIDATED STATEMENTS OF INCOME - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue:
Net product sales	$ 9,161.1	$ 7,563.8	$ 6,362.3
Other revenue	94.9	106.6	131.6
Total revenue	9,256.0	7,670.4	6,493.9
Expenses:
Cost of goods sold (excluding amortization of acquired intangible assets)	420.1	385.9	340.4
Research and development	3,697.3	2,430.6	2,226.2
Selling, general and administrative	2,305.4	2,027.9	1,684.5
Amortization of acquired intangible assets	279.0	258.3	262.8
Acquisition related charges and restructuring, net	299.6	48.7	171.1
Total costs and expenses	7,001.4	5,151.4	4,685.0
Operating income	2,254.6	2,519.0	1,808.9
Other income and (expense):
Interest and investment income, net	31.1	28.2	22.0
Interest (expense)	(310.6)	(176.1)	(91.6)
Other income (expense), net	48.4	(43.7)	(73.9)
Income before income taxes	2,023.5	2,327.4	1,665.4
Income tax provision	421.5	327.5	215.5
Net income	$ 1,602.0	$ 1,999.9	$ 1,449.9
Net income per share (Note 1):
Basic (in dollars per share)	$ 2.02	$ 2.49	$ 1.75
Diluted (in dollars per share)	$ 1.94	$ 2.39	$ 1.68
Weighted average shares (Note 1):
Basic (in shares)	792.2	802.7	827.7
Diluted (in shares)	824.9	836.0	860.6